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Introduction: The impact of moderate haemophilia on health-related quality of life (HRQoL) and physical activity (PA) is not well known. In previous studies, persons with factor VIII/factor IX activity (FVIII/FIX:C) below 3 IU/dL were associated with a more severe bleeding phenotype than predicted. Aim: To explore HRQoL and PA in patients with moderate haemophilia A (MHA) and B (MHB). Methods: A c

The prototypical chalcogenide perovskite BaZrS3, characterized by its direct band gap, exceptionally strong light-harvesting ability, and good carrier transport properties, provides fundamental prerequisites for a promising photovoltaic material. This inspired the synthesis of BaZrS3 in the form of thin films, using sputtering and rapid thermal processing, aimed at device fabrication for future op

We investigate network nonlocality in the triangle scenario when all three parties have no input and binary outputs. Through an explicit example, we prove that this minimal scenario supports nonlocal correlations compatible with no-signaling and independence of the three sources, but not with realisations based on independent quantum or classical sources. This nonlocality is robust to noise. Moreo

Artificial Kitaev chains, formed by quantum dots coupled via superconductors, have emerged as a promising platform for realizing Majorana bound states. Even a minimal Kitaev chain (a quantum dot-superconductor-quantum dot setup) can host Majorana states at discrete sweet spots. However, unambiguously identifying Majorana sweet spots in such a system is still challenging. In this work, we propose a

Addressing intertwined crises of climate change and biodiversity loss is a pressing global challenge, with trees playing pivotal roles in promoting carbon sequestration and habitat diversity. However, there is a distinct knowledge gap concerning the global drivers shaping tree cover and its heterogeneity, particularly the roles and relative importance of large herbivores and fire compared to clima

Genomic analyses have redefined the molecular subgrouping of pediatric acute lymphoblastic leukemia (ALL). Molecular subgroups guide risk-stratification and targeted therapies, but outcomes of recently identified subtypes are often unclear, owing to limited cases with comprehensive profiling and cross-protocol studies. We developed a machine learning tool (ALLIUM) for the molecular subclassificati

We present a Left-Right symmetric model that provides an explanation for the mass hierarchy of the charged fermions within the framework of the Standard Model. This explanation is achieved through the utilization of both tree-level and radiative seesaw mechanisms. In this model, the tiny masses of the light active neutrinos are generated via a three-loop radiative inverse seesaw mechanism, with Di

Terahertz (THz) technologies provide opportunities ranging from calibration targets for satellites and telescopes to communication devices and biomedical imaging systems. A main component will be broadband THz absorbers with switchability. However, optically switchable materials in THz are scarce and their modulation is mostly available at narrow bandwidths. Realizing materials with large and broa

Three-dimensional printing (3DP) is emerging as an innovative manufacturing technology for biomedical and pharmaceutical applications, since the US FDA approval of Spritam as a 3D-printed drug. In the present review, we have highlighted the potential benefits of 3DP technology in healthcare, such as the ability to create patient-specific medical devices and implants, as well as the possibility of

Scholarship addressing Shia Muslim minorities in Western contexts often refers to them as a ‘minority within a minority’ or ‘the other within the other,’ highlighting their dual-marginalization within non-Muslim societies. This paper challenges the concept of double-marginalization by examining the dynamics of transnational Shia communal spaces in north-west London and the creation of Shia spaces

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Background: Light microscopy and rapid diagnostic tests (RDT) have long been the recommended diagnostic methods for malaria. However, in recent years, loop-mediated isothermal amplification (LAMP) techniques have been shown to offer superior performance, in particular concerning low-grade parasitaemia, by delivering higher sensitivity and specificity with low laboratory capacity requirements in li

Colour polymorphism can be maintained by colour morph-specific benefits across environmental conditions. Currently, the amount and the duration of snow cover during winter decrease especially in northern latitudes, which can alter the potential for camouflage of animals with light and dark morphs. Tawny owls, Strix aluco, are colour-polymorphic avian predators with dark (brown) and light (grey) co

Technological innovation adoption by healthcare professionals directly impacts enhanced patient care and overall community well-being. However, the perspective of healthcare professionals in evaluating and adopting these technological innovations should be addressed. Drawing on innovation adoption and resistance theories, in this article, we aim to capture their perceptions of the barriers they fa

While consumer engagement (CE) in the context of artificially intelligent (AI-based) technologies (e.g., chatbots, smart products, voice assistants, or autonomous cars) is gaining traction, the themes characterizing this emerging, interdisciplinary corpus of work remain indeterminate, exposing an important literature-based gap. Addressing this gap, we conduct a systematic review of 89 studies usin

Cardiothoracic surgery using cardiopulmonary bypass (CPB) triggers an inflammatory state that may be difficult to differentiate from infection. Heparin-binding protein (HBP) is a candidate biomarker for sepsis. As data indicates that HBP normalizes rapidly after cardiothoracic surgery, it may be a suitable early marker of postoperative infection. We therefore aimed to investigate which variables i

Invasive species are predicted to adjust their morphological, physiological and life-history traits to adapt to their non-native environments. Although a loss of genetic variation during invasion may restrict local adaptation, introduced species often thrive in novel environments. Despite being founded by just a few individuals, Bombus terrestris (Hymenoptera: Apidae) has in less than 30 years suc

Background: Technological evolution leads to the constant enhancement of monitoring systems and recording symptoms of diverse disorders. Summary: For Parkinson's disease, wearable devices empowered with machine learning analysis are the main modules for objective measurements. Software and hardware improvements have led to the development of reliable systems that can detect symptoms accurately and

The new species Teuvoahtiana meridionalis is described from Antarctica and Southern South America. Even though the new species is morphologically and chemically variable, it is mo-lecularly monophyletic and located in the genus Teuvoahtiana in the subfamily Xanthorioideae. The genetic variation could not be correlated to the variation in any other characters that could support any further division