Functional analyses of leukemia associated genes
Infant (<1 year of age) acute lymphoblastic leukemia (ALL) is a malignancy characterized by rearrangements of the lysin-specific methyltransferase 2A (KMT2A/MLL) gene at 11q23 in 80% of cases and with a very poor outcome. Recently, we identified recurrent mutations in FLT3 (FLT3N676K) and PIK3R1 (PIK3R1Y580fs, PIK3R1Y580*) through whole genome sequencing of infant ALL. To gain a better understandi
