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Hydromechanical models of Darcy–Brinkman–Stokes type consider mass- and momentum conservation of an incompressible fluid on a domain with varying permeability. They include the two important limits of free flow governed by the classical Navier–Stokes equations and porous Darcy flow. The conceptual simplicity makes the model attractive from a modeling perspective, but any numerical solution procedu
The synergistic integration of biologics and additive manufacturing (AM) technologies has catalyzed groundbreaking advancements in spinal surgery. These innovations address persistent challenges, such as optimizing fusion outcomes, enhancing tissue regeneration, and achieving precise anatomical compatibility. Biologics have transformed spinal fusion by facilitating bone formation and promoting ost
Blog post at Strasbourg Observers
There is an ongoing debate about what should be considered an energy community (EC), particularly in terms of citizen engagement and the proximity of community members to renewable energy production. The type of EC that exclusively engages with actors in a certain geographical location is defined as a community of place (COP). In contrast, communities of interest (COI) do not limit membership to t
We investigated the molecular mechanisms of exercise adaptations in human muscle by integrating genome, methylome, transcriptome, and proteome data from over 1,000 participants (2,340 muscle samples). We identified distinctive signatures associated with maximal oxygen consumption (VO2max), and multi-omics integration uncovered five key genes as robust exercise markers across layers, with transcrip
Background: Patients with irritable bowel syndrome (IBS) are often interested in dietary interventions as a means of managing their symptoms. However, the relative efficacy of available diets for the management of IBS is unclear. We aimed to examine the relative efficacy of various dietary interventions in IBS. Methods: For this systematic review and network meta-analysis we searched MEDLINE, EMBA
Glycopolymers are versatile materials for biomedical and healthcare applications, e.g., as carrier and polymeric therapeutics. Especially, the topology and surface composition of such materials play a key role in being promising materials in the anti-amyloidogenic interventions. Herein, 2nd and 3rd generation of pseudo-glycodendrimers (PGDs), based on hyperbranched polyester core with different su
Major Depression (MD) and General Anxiety Disorder (GAD) are the most common mental health disorders, which typically are assessed quantitatively by rating scales such as PHQ-9 and GAD-7. However, recent advances in natural language processing (NLP) and machine learning (ML) have opened up the possibility of question-based computational language assessment (QCLA). Here we investigate how accurate
Double cones have been described in the retinae of both fishes and tetrapods. While fish double cones are two closely attached single cones, the two members of tetrapod double cones each evolved to be distinctly different from all single cones.
The evolution of reproductive isolation is a key evolutionary process, but the factors that shape its development in the early stages of speciation require clarification. Here, using a meta-analysis of 34 experimental speciation studies on arthropods, yeast and vertebrates, we show that populations subject to divergent selection evolved stronger reproductive isolation compared with populations tha
Chaperones may retard the aggregation of other proteins and increase their solubility. An important goal is a thermodynamic understanding of such an action. Here, the chaperone DNAJB6b (JB6) is found to suppress amyloid formation of the protein α-synuclein (α-syn) leading to a reduced rate of fibril formation and an increase in apparent solubility of α-syn. These findings were reached at mildly ac
Background and Aims: No-touch saphenous vein harvesting may enhance graft patency and improve clinical outcomes after coronary artery bypass grafting (CABG). Methods: In this registry-based, randomized trial, patients undergoing CABG were randomly assigned to no-touch or conventional harvesting. The primary composite outcome was the proportion of patients with occluded/stenosed >50% vein graft on
The live microbiota of tea has not been extensively investigated. This study aimed to identify the live, culturable microbiota from four types of tea with varying oxidation levels, before and after brewing. Tea leaves and brews from oolong and fermented teas were analyzed for total viable counts of aerobic bacteria, lactobacilli, fungi, and Enterobacteriaceae. Cultivation was performed and isolate
Background: Serum 1,3-β-d-glucan (BDG) tests are frequently used for diagnosing invasive candidiasis. However, BDG tests remain negative in many patients with candidemia, and factors influencing the probability for positive test results are poorly understood. Objectives: To study clinical and microbiological factors predictive of a positive BDG test, as well as the association of a positive BDG te
This longitudinal observational study aimed to determine if ventricular dimensions of the athlete's heart remain balanced and proportional to peak oxygen uptake (VO2peak) following long-term deconditioning in elite athletes. Fourteen mixed-type male athletes (7 soccer, 7 handball players) were prospectively evaluated with cardiac magnetic resonance imaging and cardiopulmonary exercise testing whil
This article explores the multifaceted challenges to organisational legitimacy encountered by international nongovernmental organisations (INGOs) operating in India. It seeks to uncover the factors that make certain organisations more susceptible to regulatory restrictions than others despite operating within a shared geopolitical landscape. The research delves into the complexities surrounding IN
