Sökresultat

External ATP has been proposed to be an autocrine regulator of glucose-stimulated insulin secretion and responsible for the synchronization of the Ca2+ rhythmicity in the P-cells required for a pulsatile release of insulin from the pancreas. The importance of external ATP for glucose-stimulated insulin release was evaluated in rats with the aid of 2-deoxy-N-methyladenosine3,5-bisphosphate (MRS 217

Using angle resolved photoemission we have investigated annealing-induced changes in Ga1-xMnxAs with x=0.05. We find that the position of the Fermi energy is a function of annealing time and temperature. It is also established that the Curie temperature is strongly correlated to the separation between the Fermi level and the valence band maximum. Valence band photoemission shows that the Mn3d spec

Glazed spaces ranging from small glazed verandas to large atrium buildings have become a common feature in architecture. A glazed space is greatly affected by aspects of the outside climate such as insolation and temperature. In the design of such spaces, more sophisticated design tools are therefore required in order to estimate the climate inside the glazed space and the energy requirements for

A critical review of some main themes in the book.

The combination of quantum mechanics and molecular mechanics (QM/MM) is one of the most promising approaches to study the structure, function, and properties of proteins. We here review our applications of QM/MM methods to alcohol dehydrogenase, blue copper proteins, iron–sulphur clusters, ferrochelatase, and myoglobin. We also describe our new quantum refinement method, which is a combination of

In this report a rather comprehensive analysis is made of the frost and salt scaling resistance of concrete. Both theoretical and empirical information are provided. On that basis recommendations are given for the concrete quality that is required for a certain service life and also recommendations for testing of concrete with regard to its potential frost resistance.

In phenotype experiments in mice, determination of dynamic insulin sensitivity often uses the insulin tolerance test. However, the interpretation of this test is complicated by the counterregulation occurring at low glucose. To overcome this problem, we determined the dynamic insulin sensitivity after inhibition of endogenous insulin secretion by diazoxide (25 mg/kg) in association with intravenou

Allelopathy, the release of extracellular compounds that inhibit the growth of other microorganisms, may be one factor contributing to the formation and/or maintenance of cyanobacterial blooms. We investigated the allelopathic effects of three cyanobacterial species (Nodularia spumigena, Aphanizomenon flos-aquae and Anabaena lemmermannii) that frequently form mass-occurrences in the Baltic Sea. We

Excited state properties of three (neutral, weak and strong) acceptor-substitute carotenoids (beta-carotene) are studied theoretically with the methods of two-dimensional (2D) and three-dimensional (3D) real-space analysis. The influences of different (neutral, weak and strong) function groups attached to the polyene chain to the excited state property of the carotenoids are discussed. By the 3D r

Propofol, an intravenous anaesthetic, has been shown to interact with the beta -subunit of the gamma -amino butyric acid(A) (GABA(A) ) receptor and also to cause changes in [Ca2+ ](i) . The GABA(A) receptor, a suggested target for anaesthetics, is known to be regulated by kinases. We have investigated if tyrosine kinase is involved in the intracellular signal system used by propofol to cause anaes

Thumbelina is one of Hans Christian Andersen´s most well-known tales, found worldwide in a wealth of translations and many illustrative versions, featuring not only in printed forms but also as children´s theatre, animated films and – in the bicentenary year of 2005 – also as a ballet with scenography and costume by Her Majesty Margrethe II, Queen of Denmark. In Odense, Andersen´s native city, the

Clinical vascular features, either as manifest vascular disease or as cardiovascular risk factors were compared in AD with and without neuropathological white matter disease (WMD). The aim of the study was to investigate whether the presence of WMD and the severity of either AD pathology or WMD were associated with different cardiovascular profiles. A total of 44 AD cases were retrospectively stud