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Mutations in either mitochondrial DNA (mtDNA) or nuclear genes that encode mitochondrial proteins may lead to dysfunctional mitochondria, giving rise to mitochondrial diseases. Some mitochondrial myopathies, however, present without a known underlying cause. Interestingly, methylation of mtDNA has been associated with various clinical pathologies. The present study set out to assess whether mtDNA

Therapeutic strategies directed at the tumor surfaceome (TS), including checkpoint inhibitor blocking antibodies, antibody drug conjugates (ADCs), and chimeric antigen receptor T (CAR-T) cells, provide a new armament to fight cancer. However, a remaining bottleneck is the lack of strategies to comprehensively interrogate patient tumors for potential TS targets. Here, we have developed a platform (

Bartonella henselae is the causative agent of cat scratch disease and other clinical entities such as endocarditis and bacillary angiomatosis. The life cycle of this pathogen, with alternating host conditions, drives evolutionary and host-specific adaptations. Human, feline, and laboratory adapted B. henselae isolates often display genomic and phenotypic differences that are related to the express

Traffic on railways is increasing and this makes train traffic to be highly interconnected . This paper investigates how passing of train affects dwell time delays in Sweden. Three scenarios are considered by combining the scheduled and actual operations: passes that happened as scheduled, unscheduled passes that happened in operations, and scheduled passes that were cancelled. A logistic regressi

This study investigates how the volume and flow of passengers affect dwell times, usingdata from commuter trains in Stockholm. We show that dwell times often take longer thanscheduled and that most station stops involve rather limited numbers of passengers.Improving the performance at these stops with small volumes can thus have a sizeableimpact on the overall on-time performance. We find a quadraThis study investigates how the volume and flow of passengers affect dwell times, using data from commuter trains in Stockholm. We show that dwell times often take longer than scheduled and that most station stops involve rather limited numbers of passengers. Improving the performance at these stops with small volumes can thus have a sizeable impact on the overall on-time performance. We find a qu

Background: Several studies indicate increasing hospitalisation rates for specific infectious diseases (IDs). Studies describing the entire ID spectrum are scarcer. Our aim was to describe hospital use with ID diagnoses in Swedish adults from 1998 to 2019. Methods: All four-position codes in ICD-10 were reclassified as ID or non-ID diagnoses. Using data from the National Patient Register, age-stan

Human cholangiocyte organoids are promising for regenerative medicine applications, such as repair of damaged bile ducts. However, organoids are typically cultured in mouse tumor-derived basement membrane extracts (BME), which is poorly defined, highly variable and limits the direct clinical applications of organoids in patients. Extracellular matrix (ECM)-derived hydrogels prepared from decellula

For a train speed close to the speed of elastic waves in the soil, often referred to as “critical speed”, largely elevated vibration responses occur. This can be a practical problem for soft soil sites, where the phenomenon may cause excessive vibrations in the track and also at distances far from the track. To ensure the running safety of the train, the long-term quality of the track and to reduc

The success of optically stimulated luminescence (OSL) dating relies to a large extent on suitable characteristics of the analysed mineral, in this case quartz. Previous OSL dating of Quaternary sediments in Scandinavia has shown that quartz characteristics vary widely across the region, resulting in dating studies with varied success. The aim of this study is to provide an overview of quartz lumi

Objective: We aimed to study whether antipsychotic use during pregnancy is associated with gestational diabetes. Methods: This was a Swedish national register‐based cohort study on the Medical Birth Register and the Prescribed Drug Register including all 1,307,487 singleton births between July 2006 and December 2017. Antipsychotics were divided into first-generation antipsychotics (n = 728), high-

In the afterburner assembled with an air-cooled bluff-body flameholder, cooling air is directly injected into the recirculation zone behind the bluff-body, which can reduce the local temperature and increase the oxygen concentration of the gas mixture in the wake of the bluff-body, thereby affecting the total pressure loss and combustion characteristics. To better understand the flow and combustio