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Modeling the assembly of oppositely charged lock- and key-colloids

The interaction of oppositely charged lock- and key-colloids is investigated using computer simulations. We show that indented spheres, i.e., lock-particles, can be specifically assembled with spherical key-particles using solely electrostatic interactions in addition to a hard overlap potential. An analytic description of the entropic and energetic contributions is derived and supported by simula

Combined protein A imprinting and cryogelation for production of spherical affinity material

Cryogels have been demonstrated to be efficient when applied for protein isolation. Owing to their macroporous structure, cryogels can also be used for treating particle-containing material, e.g. cell homogenates. Another challenging development in protein purification technology is the use of molecularly imprinted polymers (MIPs). These MIPs are robust and can be used repeatedly. The paper presen

Attitudes matter : Perceptions towards welfare work with migrants in Swedish welfare organisations

This dissertation examines Swedish welfare workers’ attitudes towards migrants and migration, their perceptions of welfare work with migrants and organisational working conditions. The dissertation is based on original survey data capturing attitudes and views of welfare workers in two Swedish welfare organisations. The thesis’ conceptual framework draws on three perspectives: street-level bureauc

Thoracic endovascular aortic repair with stent grafts alone or with a composite device design in patients with acute type B aortic dissection in the setting of malperfusion

Objective: The objective of this study was to compare short-term outcomes in patients who underwent thoracic endovascular aortic repair (TEVAR) with stent grafts alone or with a composite device design (stent graft plus bare-metal aortic stent) for acute type B aortic dissection in the setting of malperfusion. Methods: This retrospective analysis included patients with acute (≤14 days of symptom o

Informal caregivers in stroke : Life impact, support, and psychological well-being—A Swedish Stroke Register (Riksstroke) study

Background: Informal caregivers provide a large amount of day-to-day assistance and are crucial for the ability of survivors to recover and adapt to life after stroke. Aim: The development of caregiver support programs is limited by lack of large long-term follow-up studies. We present a comprehensive study of Swedish stroke caregivers' life situation in relation to degree of functional dependency

Primary fatty amides are potential plasma biomarkers for AD

A new study has found that levels of primary fatty amides in plasma correlate with amyloid-β pathology and other Alzheimer disease (AD)-related phenomena. In addition to identifying potential plasma biomarkers for AD, the findings suggest new avenues for investigation into the early stages of AD.

The emerging role of omega-3 fatty acids as a therapeutic option in neuropsychiatric disorders

The prevalence of neurologic and psychiatric diseases has been increasing for decades and, given the moderate therapeutic efficacy and safety profile of existing pharmacological treatments, there is an urgent need for new therapeutic approaches. Nutrition has recently been recognized as an important factor for the prevention and treatment of neuropsychiatric disorders. The omega-3 polyunsaturated

Investigation on bluff-body and swirl stabilized flames near lean blowoff with PIV/PLIF measurements and LES modelling

Lean premixed combustion (LPC) is a promising technology for low-NOx emission, while it increases the risk of blowoff at the same time. Experiments and Large Eddy Simulations (LES) on swirl stratified lean-premixed CH4/air flames were performed to study the differences between the stable and near blowoff flame. The flow fields and instantaneous flame structures were measured by simultaneous Partic

Polypoidal Choroidal Vasculopathy Associate With Diminished Regulatory T Cells That Are Polarized Into a T Helper 2-Like Phenotype

Purpose: To investigate possible roles of T helper (Th) cells, regulatory T cells (Tregs), and the recently mapped Th-like Tregs in patients with polypoidal choroidal vasculopathy (PCV). Methods: In this prospective case-control study, we obtained fresh venous blood from patients with PCV (n = 24), age-matched healthy controls (n = 32), and patients with neovascular AMD (n = 45). All participants

Danon disease presenting with early onset of hypertrophic cardiomyopathy and peripheral pigmentary retinal dystrophy in a female with a de novo novel mosaic mutation in the LAMP2 gene

Purpose: To describe the phenotype and genotype in a young woman with Danon disease. Methods: The patient underwent an ophthalmic examination including best corrected visual acuity (BCVA), fundus photography and fundus autofluorescence (FAF), full-field electroretinography (full-field ERG), multifocal ERG, optical coherence tomography (OCT) and SAP-Humphrey 30–2 at the ages of 20 and 25. Electrooc

Comparison of different clothing area factor (fcl) calculations based on picture analysis in Adobe Photoshop : To calculate the intrinsic insulation (Icl)

Introduction: Clothing area factor (fcl) is an indicator of the increase in surface area relative to the nude body for calculation of heat loss from the clothed body to the environment. The aim was to calculate and compare the fcl values from two equations by the photographic method.Method: Thirty-five modern western indoor clothing sets (19 male and 16 female) were tested on a thermal manikin Tor

Incidence, survival and mortality trends of bladder cancer in Sweden 1997–2016

Objective: To evaluate trends in bladder cancer incidence, survival and mortality in Sweden from 1997–2016. Patients and methods: The Swedish National Registry of Urinary Bladder Cancer is a nation-wide quality register that started in 1997. It includes information on initial tumor characteristics and treatment; 41,097 new cases were registered up to 2016. Patients were stratified into four time p

Breast-feeding during Pregnancy and the Risk of Miscarriage

ContextBreastfeeding rates and durations have been increasing among American women in recent decades, but a consequence of these trends is that women may be more likely to practice breastfeeding during pregnancy (BDP). BDP has been hypothesized to increase the risk of miscarriage, yet there has been little research investigating if this is the case.MethodsUsing data on 10,661 pregnancies from the

Functional characterization of novel germline TP53 variants in Swedish families

Pathogenic germline TP53 variants predispose to a wide range of early onset cancers, often recognized as the Li-Fraumeni syndrome (LFS). They are also identified in 1% of families with hereditary breast cancer (HrBC) that do not fulfill the criteria for LFS. In this study, we present a total of 24 different TP53 variants identified in 31 Swedish families with LFS or HrBC. Ten of these variants, ni

Piano Works : Compositions by Staffan Storm

Label: Daphne records 1036Piano works composed 1989-2009 performed by Francisca Skoogh and Roland Pöntinen1 - L'heure bleue, 20052-4 Trois tableaux, 2006-095 - I skuggan av en sommar, 19896-9 Lied vom Meer, 200910 - Das Gift, 1993

Self-healing photo-neuropathy and cervical spinal arthrosis in four sisters with brachioradial pruritus.

The cause of brachioradial pruritus (a localized itching on the arms or shoulders) is controversial. The role of sun and cervical spine disease has been discussed. This is a report on four sisters suffering from brachioradial pruritus recurring every summer. The sisters spent much time outdoors and exposed themselves extensively to the sun. They also had occupations requiring heavy lifting. Cervic