Multiple sclerosis (MS) shares some risk genes with other disorders hallmarked by an autoimmune pathogenesis, most notably IL2RA and CLEC16A. We analyzed 10 single-nucleotide polymorphisms (SNPs) in nine risk genes, which recently emerged from a series of non-MS genome-wide association studies (GWAS), in a Spanish cohort comprising 2895 MS patients and 2942 controls. We identified two SNPs associa

MuscleAtlasExplorer is a freely available web application that allows for the exploration of gene expression data from human skeletal muscle. It draws from an extensive publicly available dataset of 1654 skeletal muscle expression microarray samples. Detailed, manually curated, patient phenotype data, with information such as age, sex, BMI and disease status, are combined with skeletal muscle gene

The aim of this study was to reveal how hospital nurses handle the process when older people are considering relocation to a residential home after hospitalization. The focus is of special interest as, in Sweden, hospital nurses are employed by a county council without the authority to decide on local municipal care after hospital discharge. Ten nurses from three hospital wards participated in ope

The importance of previous suicidal behavior for the treatment of alcoholics was analyzed in a long‐term outpatient treatment study. In a series of 72 patients, 21 patients, (29%), 17 men and 4 women, had previously made at least one suicide attempt or had seriously threatened to kill themselves (3 cases). In comparison with the other alcoholics, those with previous suicidal behavior had a similar

Seventy-two alcoholic patients (60 men and 12 women) were randomized into four groups who received psychiatric treatment (PT) or multimodal behavioural therapy (MBT), for either 1 or 2 years. PT was based on psychodynamic principles, and MBT is a cognitive-behavioural treatment. The patients accepting treatment had a mean age of 37 ± 9 years, and they were socially stable. There was no difference

This paper contemplates the future of utility infrastructure, and considers whether an "All-in-One" approach could supply all necessary utility services to tomorrow's households.The intention is not to propose infrastructure solutions that are currently technically feasible or justifiable, however; the objective is to present visions of future infrastructure that would only be possible with new ad

This book is a classic work of twentieth-century legal philosophy. The first translation into English was notably poor and misrepresented the views expressed in the text. Translated from scratch from the original Danish, this new critical edition casts light on the work and resituates it firmly in the context of current debates in the field.

Background: The rising prevalence of type 2 diabetes (T2D) poses a major global challenge. It remains unresolved to what extent transcriptomic signatures of metabolic dysregulation and T2D can be observed in easily accessible tissues such as blood. Additionally, large-scale human studies are required to further our understanding of the putative inflammatory component of insulin resistance and T2D.

In this article, we consider scenarios in which traditional estimates for the active subspace method based on probabilistic Poincaré inequalities are not valid due to unbounded Poincaré constants. Consequently, we propose a framework that allows to derive generalized estimates in the sense that it enables to control the trade-off between the size of the Poincaré constant and a weaker order of the

På kort tid har coronapandemin utlöst en djup ekonomisk kris i Sverige. Härpresenterar vi en första obduktion av krisen. Vi jämför dagens krisförlopp medde två senaste kriserna, finanskrisen 1991–93 och den internationella finanskrisen 2008–09. Vi kartlägger hur svensk ekonomi har påverkats samt belyser de kortsiktiga samhällsekonomiska kriskostnaderna. Därefter beskrivs krispolitiken. Här ställs

Gothenburg is a flourishing green city, with nearly 600,000 inhabitants, located on the west coast of Sweden. Gothenburg has a long tradition of a strong civil society and grass roots movement, which is also reflected when it comes to the development of the sharing economy in the city. Many of the sharing initiatives come from civil society organizations, but the local government has also taken an

It is becoming increasingly evident that the field of language documentation and the docu¬mentary multimedia resources it produces rely on expanding their relevance and usability to disciplines beyond linguistics in order to increase their chances of being sustainable in the long term. This paper argues that more attention should be paid to the needs and interests of such disciplines in language d

For patients with end-stage respiratory diseases, such as COPD, interstitial lung diseases and cystic fibrosis, lung transplantation remains the only treatable option. However, due to increasing demand and limited availability of donor lungs, risk of complications such as acute and chronic rejection, and adverse effects of immunosuppressive treatments, this is not an alternative for the majority o