Filtyp
The 90 kDa ribosomal S6 kinase (RSK) family of proteins is a group of highly conserved Ser/Thr kinases. They are downstream effectors of the Ras/ERK/MAPK signaling cascade. ERK1/2 activation directly results in the phosphorylation of RSKs, which further, through interaction with a variety of different downstream substrates, activate various signaling events. In this context, they have been shown t
Increasing discontent with the current status of democracy has prompted a renewed interest in Athenian democracy. This article contributes with the first comparative analysis of two political theoreticians – Hannah Arendt and Ellen Meiksins Wood – whose reactivations of ancient political experiences significantly predate recent trends. Despite the fact that Arendt levelled fierce critique against
Aim: Children born extremely preterm frequently have developmental coordination disorder (DCD). We aimed to evaluate perinatal risk factors for DCD. Methods: Swedish national cohort study including 226 children born before 27 gestational weeks without major neurodevelopmental disabilities at 6.5 years. Outcome was DCD, defined as ≤5th percentile on the Movement Assessment Battery for Children-Seco
An important camp within the emerging field of resistance studies has been characterised by a tendency to study and theorise matters of culture, language, and discourse at the expense of matter itself. For researchers interested in feminist resistance, feminist new materialism – with its focus on the entanglements of ‘natureculture’, matter, the body, sexual differ- ence, agency, and change – mighAn important camp within the emerging field of resistance studies hasbeen characterised by a tendency to study and theorise matters of culture,language, and discourse at the expense of matter itself. For researchersinterested in feminist resistance, feminist new materialism – with its focuson the entanglements of ‘natureculture’, matter, the body, sexual differ-ence, agency, and change – might app
Allergen specific immunotherapy (AIT) is the only causal therapeutic option for allergic airway diseases including asthma and allergic rhinitis. AIT has been shown to restore the allergen immune tolerance, can modify both the early and late-onset allergen-specific airway hyperreactivity, helps to achieve disease control/remission and prevents new sensitisations. Recent real life data on long-term
In recent decades, a ‘Haitian Turn’ has emerged as both academic and public readerships in the anglophone sphere have been flooded by a wave of essays, articles, and monographs on the Haitian Revolution (1791–1804). At the epicentre of the present study is one of the major interpretations of the Haitian Revolution in the Haitian Turn, which I call the ‘universality paradigm’. The universality paraIn recent decades, a ‘Haitian Turn’ has emerged as both academic and public readerships in the anglophone sphere have been flooded by a wave of essays, articles, and monographs on the Haitian Revolution (1791–1804). At the epicentre of the present study is one of the major interpretations of the Haitian Revolution in the Haitian Turn, which I call the ‘universality paradigm’. The universality para
Purpose: Getting an incurable oesophageal or gastric cancer diagnosis is a major stressful life event associated with severe physical, psychosocial and existential challenges. To provide timely and efficient support, based on patients' experiences, the aim of the study was to explore how patients newly diagnosed with incurable oesophageal and gastric cancer manage everyday life. Method: Semi-struc
Purpose: To assess the risk of recurrent venous thromboembolism (VTE) and death in patients with unreported cancer-associated incidental pulmonary embolism (iPE). Materials and methods: Matched cohort study on cancer patients with a CT study including the chest between 2014-01-01 and 2019-06-30. Studies were reviewed for unreported iPE, and cases were matched with controls without iPE. Cases and c
Asthma is typically characterized by variable respiratory symptoms and airflow limitation. Along with the pathophysiology and symptoms are immunological and inflammatory processes. The last decades research has revealed that the immunology of asthma is highly heterogeneous. This has clinical consequences and identification of immunological phenotypes is currently used to guide biological treatment
Channel fabrication technology has become increasingly important for microfluidic and nanofluidic devices. In particular, glass channels have high chemical and physical stability, high optical transparency, and ease of surface modification, so that there is increasing interest in glass microfluidic devices for chemical experiments in microfluidics and nanofluidics. For the fabrication of glass cha
Many Arctic-breeding animals are at risk from local extirpation associated with habitat constriction and alterations in phenology in their Arctic environment as a result of rapid global warming.1 Migratory species face additional increasing anthropogenic pressures along their migratory routes such as habitat destruction, droughts, creation of barriers, and overexploitation.2,3 Such species can onl
Sammantagningsvis tar det här temanumret upp viktiga aspekter rörande coronapandemins effekter på arbetslivet. Utifrån artiklarna vill vi särskilt lyfta följande fyra punkter som angelägna för framtiden:- facket och skyddsombuden i Sverige spelar viktiga roller för bedömning avarbetsmiljörisker vid kriser, såsom coronapandemin.- goda arbetsvillkor i vardagen är avgörande för vård- och omsorgssekto
A major theme of the current “Haitian turn” has been what I call a “universality-analysis”, which stresses that the Haitian Revolution, in contrast to the American and the French, once and for all abolished slavery. The chapter investigates the intervention into the Haitian Turn by two scholars specialized in the history of human rights: Lynn Hunt, who advocates a universality-analysis of the HaitA major theme of the current “Haitian turn” has been what I call a “universality-analysis”, which stresses that the Haitian Revolution, in contrast to the American and the French, once and for all abolished slavery. The chapter investigates the intervention into the Haitian Turn by two scholars specialized in the history of human rights: Lynn Hunt, who advocates a universality-analysis of the Hait
Identification of protein structural neighbors to a query is fundamental in structure and function prediction. Here we present BS-align, a systematic method to retrieve backbone string neighbors from primary sequences as templates for protein modeling. The backbone conformation of a protein is represented by the backbone string, as defined in Ramachandran space. The backbone string of a query can
Many studies have demonstrated that shape string is an extremely important structure representation, since it is more complete than the classical secondary structure. The shape string provides detailed information also in the regions denoted random coil. But few services are provided for systematic analysis of protein shape string. To fill this gap, we have developed an accurate shape string predi
Conformal prediction has been proposed as a more rigorous way to define prediction confidence compared to other application domain concepts that have earlier been used for QSAR modeling. One main advantage of such a method is that it provides a prediction region potentially with multiple predicted labels, which contrasts to the single valued (regression) or single label (classification) output pre
Chemogenomics data generally refers to the activity data of chemical compounds on an array of protein targets and represents an important source of information for building in silico target prediction models. The increasing volume of chemogenomics data offers exciting opportunities to build models based on Big Data. Preparing a high quality data set is a vital step in realizing this goal and this
The volume of high throughput screening data has considerably increased since the beginning of the automated biochemical and cell-based assays era. This information-rich data source provides tremendous repurposing opportunities for data mining. It was recently shown that biochemical or cell-based assay results can be compiled into so-called high-throughput fingerprints (HTSFPs) as a new type of de
