Fluxes of calcium ions (Ca2+) in rod photoreceptors are major regulators of steady-state and light-evoked intracellular reactions to stimuli. The homeostasis of Ca2+ is regulated by channels and pumps localized at the plasma membrane and in intracellular organelles. Photoreceptor degeneration is frequently associated with Ca2+ homeostasis disruption and stimulation of Ca2+ activated proteases, suc

The metaphor of a potential epigenetic differentiation landscape broadly suggests that during differentiation a stem cell approaches a stable equilibrium state from a higher free energy towards a stable equilibrium state which represents the final cell type. It has been conjectured that there is an analogy to the concept of entropy in statistical mechanics. In this context, in the undifferentiated

The number of onshore wind turbines in Europe has greatly increased over recent years, a trend which can be expected to continue. However, the effects of wind turbine noise on long-term health outcomes for residents living near wind farms is largely unknown, although sleep disturbance may be a cause for particular concern. Presented here are two pilot studies with the aim of examining the acoustic

Agriculture plays a crucial role in meeting the Sustainable Development Goals, with organic farming being one important potential contributor to environmental, economic, and social sustainability. Despite a national goal of 20% organic agriculture, currently only 6.2% of Germany's farmland is organic, and conversion rates are slowing down. However, one bright spot is organic viticulture in Germany

A search for resonant and nonresonant pair production of Higgs bosons in the bbτ+τ- final state is presented. The search uses 36.1 fb-1 of pp collision data with s=13 TeV recorded by the ATLAS experiment at the LHC in 2015 and 2016. Decays of the τ-lepton pairs with at least one τ lepton decaying to final states with hadrons and a neutrino are considered. No significant excess above the expected b

This article examines the involvement of Private Military and Security Companies (PMSC) in both shaping and implementing the European Agenda on Migration (European Agenda), launched by the European Union in May 2015. The migration policies which have since been adopted have increasingly enabled the outsourcing to private security contractors of various border control operations, including those re

During the first five months of 2015 approximately 1,850 people died across the Mediterranean whilst attempting to reach the European Union (EU). In response to this, in April 2015 the Commission presented a 10-point action plan, on the basis of which the Council agreed to strengthen the EU’s ‘presence at sea, to fight traffickers, to prevent illegal migration flows and to reinforce internal solid

Evidence-based practice (EBP) has been launched, spread, and established in social work in Sweden in the last decade. Today, impact studies and ‘what works’ are the recommended approaches, and medical ways to understand and examine social problems thus are prioritised over the broad social science perspectives on which social work rests. This development has culminated in an institutionalised syst

Objectives: Gram-positive, anaerobic cocci (GPAC) can cause infections in humans. Only a few cases of bacteraemia with GPAC have been reported. We describe the clinical and microbiological characteristics of GPAC bacteraemia. Methods: A retrospective population-based study of GPAC bacteraemia 2012–2016 in southern Sweden was performed. GPAC were identified using matrix-associated laser desorption

Binding of three mutagens, known to occur in fried or broiled foods, by thirteen different types of dietary fiber was investigated in vitro. Nonspecific binding by other food polymers was minimized by using protease and amylase treatment. Water‐insoluble fiber components were responsible for most of the binding capacity. Generally, a slightly larger proportion of 2‐amino‐3,4‐dimethylimidazo [4,5‐f

The present author has investigated the frequency with which normal appendices are found at appendectomy in different phases of the menstrual cycle. The study is based on 504 female patients, 15–45 years of age, who were perated on for suspected acute appendicitis during the period from 1976 to 1982. The results are shown in Tables 1 and 2. The frequency of acute appendicitis in the luteal phase o

From the results of the study presented, it can be concluded that, in a group of patients not using contraceptive pills, a significant difference is noted in the frequency of acute appendicitis and the number of appendectomies performed in the different phases of the menstrual cycle. This difference almost disappears in the group of patients using the contraceptive pill. These results suggest that

The orientation towards grand societal challenges can be seen as a new wave or paradigm for innovation policy. Such policy aims at system-wide transformation and is often referred to as system innovation policy. While insights from transition studies have provided novel and useful rationales for innovation policy targeting system-wide transformation, it remains unclear how to design, implement and

A follow-up study of 12 patients who had undergone Stephens rectoplasty for high imperforate anus is presented. Clinical assessment and anal electromyography were performed more than 7 years after surgery, both before and after a year's physiotherapeutic training of the perianal musculature. Electromyography showed correlation between faecal continence and tonus of the anal sphincter, the anocutan

At present our knowledge of enteric peptide-containing neurons in man is limited. In this study we have used human appendices removed at surgery to examine the peptidergic innervation by immunocytochemistry, immunochemistry, and pharmacological in vitro experiments. Immunocytochemistry revealed a variety of peptide-containing nerve fiber populations in the human appendix. VIP/PHI-, VIP/PHI/NPY-, S