Colliders, among the most successful tools of particle physics, have revealed much about matter. This review describes how colliders contribute to the search for particle dark matter, focusing on the highest-energy collider currently in operation, the Large Hadron Collider (LHC) at CERN. In the absence of hints about the character of interactions between dark matter and standard matter, this revie

Multiple clinical trials investigate statins' effects in breast cancer. The ABCB1 genotype appears to influence statin response and toxicity in the cardiovascular setting. This exploratory study aimed to investigate the interplay between preoperative statin use, ABCB1 genotype, and tumor-specific expression of the statin target 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in breast canc

Nutritional status provides metabolic substrates to activate AMP-Activated Protein Kinase (AMPK), the energy sensor that regulates metabolism. Recent evidence has demonstrated that AMPK has wider functions with respect to regulating immune cell metabolism and function. One such example is the regulatory role that AMPK has on NLRP3-inlflammasome and IL-1β biology. This in turn can result in subsequ

Introduction: Shrunken pore syndrome (SPS), originally defined by cystatin C-based estimated glomerular filtration rate (eGFRcystatin C) being less than 60% of creatinine-based estimated glomerular filtration rate (eGFRcreatinine) in the absence of extrarenal influences on the plasma levels of cystatin C or creatinine, is associated with a high increase in mortality, even in the absence of reduced

The systematic review of universities and social innovations was carried out by placing universities within the broad framework of social innovation. Focus on social innovation as a response to development and societal problems, the review adopted a three-prong approach by analysing the drivers, process and impact of social innovations in the three core missions of universities: teaching, research

Transverse-momentum (pT) differential yields of electrons from semileptonic heavy-flavour hadron decays have been measured in the most central (0–10%) and in semi-central (20–40%) Pb–Pb collisions at sNN=2.76 TeV. The corresponding production cross section in pp collisions has been measured at the same energy with substantially reduced systematic uncertainties with respect to previously published

Purpose of review Chronic breathlessness is a common and distressing symptom globally. It is associated with major adverse health outcomes. This review provides an overview of new evidence about the prevalence of chronic breathlessness in the population. Recent findings A literature search was conducted using MEDLINE database including studies on prevalence of chronic breathlessness and its impact

Background and Purpose- In ischemic stroke, breakdown of the blood-brain barrier (BBB) aggravates brain damage. Pericyte detachment contributes to BBB disruption and neurovascular dysfunction, but little is known about its regulation in stroke. Here, we investigated how loss of RGS5 (regulator of G protein signaling 5) in pericytes affects BBB breakdown in stroke and its consequences. Method- We u

The growth of biomass-based markets for transport fuel is an expanding geographical process driven by regulation in the European Union (EU). Based on a certification scheme that illustrates the regulatory mechanisms in the EU’s liquid biofuel market, this article explains how larger processes of territorialisation and uneven development interact with specific processes of commodity production and

Native γ-trace, a small basic protein present in high concentration in cerebrospinal fluid, semen and neuroendocrine cells, but of unknown biological function, is shown to be a potent inhibitor of the cysteine proteinases papain, ficin, and human cathepsins B, H and L. It proves to be the tightest-binding protein inhibitor of cathepsin B so far discovered. The name cystatin C is proposed for γ-tra

Background: Epidemiological studies suggest that haem iron, which is found predominantly in red meat and increases endogenous formation of carcinogenic N-nitroso compounds, may be positively associated with lung cancer. The objective was to examine the relationship between haem iron intake and lung cancer risk using detailed smoking history data and serum cotinine to control for potential confound

Terrestrial Arctic ecosystems play a key role in the global carbon (C) cycle, as they store a large amount of organic matter in permafrost. Among regions with continuous permafrost, Svalbard has one of the warmest permafrost and may provide a template of the environmental responses of Arctic regions to future climate change. We analyze the CO2 fluxes at a polygonal tundra site in Adventdalen (Sval

Type 1 diabetes (T1D) is an autoimmune disease that targets pancreatic islet beta cells and incorporates genetic and environmental factors1, including complex genetic elements2, patient exposures3 and the gut microbiome4. Viral infections5 and broader gut dysbioses6 have been identified as potential causes or contributing factors; however, human studies have not yet identified microbial compositio

Background: Stroke is a rare disorder in childhood; among its risk factors, C677T mutations in the methylenetetrahydrofolate reductase (MTHFR) gene with secondary hyperhomocysteinemia are considered. Patients and methods: We report on a family in which two brothers had arterial ischemic stroke (AIS). One of these siblings came to our observation at the age of 4 years because of decreased motility