Background: Being born with low birth weight (LBW) is a risk factor for muscle insulin resistance and type 2 diabetes (T2D), which may be mediated by epigenetic mechanisms programmed by the intrauterine environment. Epigenetic mechanisms exert their prime effects in developing cells. We hypothesized that muscle insulin resistance in LBW subjects may be due to early differential epigenomic and tran

In the mid-19th century, the discovery that bone microstructure in fossils could be preserved with fidelity provided a new avenue for understanding the evolution, function, and physiology of long extinct organisms. This resulted in the establishment of paleohistology as a subdiscipline of vertebrate paleontology, which has contributed greatly to our current understanding of dinosaurs as living org

Solid lipid nanoparticles (SLNs) have a crystalline lipid core which is stabilized by interfacial surfactants. SLNs are considered favorable candidates for drug delivery vehicles since their ability to store and release organic molecules can be tailored through the identity of the lipids and surfactants used. When stored, polymorphic transitions in the core of drug-loaded SLNs lead to the prematur

Clinical risk factors explain only a fraction of the variability of estimated glomerular filtration rate (eGFR) decline in people with type 2 diabetes. Cross-omics technologies by virtue of a wide spectrum screening of plasma samples have the potential to identify biomarkers for the refinement of prognosis in addition to clinical variables. Here we utilized proteomics, metabolomics and lipidomics

Immune cells, such as B and T cells, fight pathogens infecting the human body. To fulfil this function the immune cells need to form a contact during which different membrane proteins play an important role. A key event in this contact is the interaction between the T-cell receptor (TCR) and an antigenic peptide-presenting major histocompatibility complex (MHC) protein. If this interaction is suff

The purpose of the dissertation is to trace the working process of Johannes Widekindi (ca 1620–1678), Swedish historiographer of the Realm, when writing his bilingual history of the Swedish military actions in Russia in 1609–1617, published in 1671 in Swedish as Thet Swenska i Ryssland tijo åhrs Krijgz-Historie and in 1672 in Latin as Historia Belli Sveco-Moscovitici Decennalis.Chapter 1 of the di

Rapporten er utarbeidet i forbindelse med FoU-prosjektet «Virkningene av voldsoffererstatning». Prosjektet har hatt som formål å gi økt kunnskap om virkninger, i betydning av bruker- og samfunnseffektene av voldsoffererstatningen.Oppdraget er gjennomført av Oxford Research. Prosjektleder har vært sjefanalytiker Tor Egil Viblemo ved Oxford Research og prosjektdeltakerne har vært Vegard Solhjem Knut

Detta kapitel kommer främst att förhålla sig till koncepten ”kodifierad statsrätt” och rätten som ”formell ordning”. Den rättssociologiska forskningens rättsliga betydelse behandlas också, och hur rättssociologisk forskning kan vara betydelsefull för att lösa juridiska problem och kanske även utgöra en ”rättskälla”. Kapitlet syftar därför till att ge ett exempel på hur man kan se på ”rättssociolog

Detta kapitel behandlar ett rättsligt instrument, avtalet, utifrån ett empiriskt perspektiv. Syftet är tvåfaldigt; dels att lyfta fram en inom rättssociologin försummad regleringsform, dels att ge en bild av vilka forskningsuppgifter studiet av avtal kan föra med sig. Det finns väsentliga skillnader mellan avtal och lag som rättsliga instrument. Lag som bekant är föreskrivande och talar om vad som

There is currently an intensive development of sugar-based building blocks toward the production of renewable high performance plastics. In this context, we report on the synthesis of a rigid diol with a spirocyclic structure via a one-step acid-catalyzed acetalation of fructose-sourced 5-hydroxymethylfurfural and pentaerythritol. Preliminary life cycle assessment (LCA) indicated that the spiro-di

Seasonal snow cover in mountainous regions will affect local climate and hydrology. In this study, we assessed the role of altitude in determining the relative importance of temperature and precipitation in snow cover variability in the Central Tianshan Mountains. The results show that: (a) in the study area, temperature has a greater influence on snow cover than precipitation during most of the t

Objective Investigating demographic and socioeconomic factors as intersecting rather than as separate dimensions may improve our understanding of the heterogeneous distribution of type 2 diabetes in the population. However, this complexity has scarcely been investigated and we still do not know the accuracy of these factors for predicting type 2 diabetes. Improved understanding of the demographic

My focus is on aggregation of individual value rankings of alternatives to a collective value ranking. This is compared with aggregation o individual prefrences to a collective preference. While in an individual preference ranking the alternatives are ordered in accordance with one’s preferences, the order in a value ranking expresses one’s comparative evaluation of the alternatives, from the best

Introduction: The effects of the GLP-1 analogue liraglutide on time in hypoglycaemia, time in hyperglycaemia, and time in range for type 2 diabetes patients initially treated with multiple daily insulin injections (MDI) were investigated. Variables associated with hypoglycaemia in the current population were also identified. Methods: Analyses were based on data from a previously performed double-b

Hypoxia regularly occurs during plant development and can be induced by the environment through, for example, flooding. To understand how plant tissue physiology responds to progressing oxygen restriction, we aimed to monitor subcellular physiology in real time and in vivo. We establish a fluorescent protein sensor-based system for multiparametric monitoring of dynamic changes in subcellular physi

Background: Neuroblastoma is the commonest extracranial solid tumor of childhood, yet rare, and with poor survival before 1990, especially for high-risk disease; thus, information on late effects is sparse. With great advances in cancer treatment, survival has reached 80% in the Nordic countries. The aim of the study was to investigate the risk of developing neurologic disorders after neuroblastom

Introduction Half of all Ugandans (49%) turn to the private or private-not-for-profit (PNFP) sectors when faced with illness, yet little is known about the capacity of these sectors to deliver surgical services. We partnered with the Ministry of Health to conduct a nationwide mixed-methods evaluation of private and PNFP surgical capacity in Uganda. Methods A standardized validated facility assessm