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Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C

The product of the c-kit proto-oncogene, denoted Kit/SCF-R, encodes a tyrosine kinase receptor for stem cell factor (SCF). Kit/SCF-R induces proliferation, differentiation or migration of cells within the hematopoietic, gametogenic and melanogenic lineages at different developmental stages. We report here that protein kinase C (PKC) mediates phosphorylation of Kit/SCF-R on serine residues in respo

Antiproliferative effects of peracetylated naphthoxylosides.

The antiproliferative activity, and the capability of priming of glycosaminoglycan chains, of two series of peracetylated mono- and bis-xylosylated dihydroxynaphthalenes have been investigated for normal HFL-1 cells, as well as transformed T24 cells, and compared to the unprotected analogs. Our data show increased antiproliferative activity upon peracetylation, but a loss of selectivity towards T2

Folket med stort F

About the complicated self-image in Denmark on what Folk (people) means, what it means to be "danish".

Frånvarande kvinnliga subjekt - en analys av medicinska texter om klimakteriet

The article "Missing female subjects. An analysis of medical texts about menopause" focuses on medical discourses about women and middle age. More concretely, it presents an analysis of articles in Läkartidningen from 1990 through 2001. Läkartidningen is the official journal of the Swedish Medical Association and has a distribution of nearly 30 000 copies. The analysis is based upon three qualitat

Gender aspects on survival among patients admitted to hospital with suspected or diagnosed heart failure.

Objectives and design. There are conflicting data on gender differences in survival among heart failure (HF) patients. We prospectively assessed gender differences in survival among 930 consecutive patients (464 [49.9%] women, mean age 76.1 +/- 10.1 years), admitted to hospital with suspected or diagnosed HF. Results. Overall, women had lower unadjusted mortality hazard ratio (HR) than men: HR 0.8

Socio-Cultural Retailing: A literature review

The aim of this paper is to contribute to the cultural turn in retail studies by offering an overview of the interdisciplinary field of socio-cultural retailing and, based on this introduction, draw out and discuss what this body of work can contribute to the field of retail marketing. The paper reviews socio- cultural retail research from the disciplines of marketing, cultural geography, sociolog

Voluntary Activation of the Knee Extensors in Chronic Poststroke Subjects.

Miller M, Flansbjer U-B, Lexell J: Voluntary activation of the knee extensors in chronic poststroke subjects. OBJECTIVE:: To assess the extent to which knee extensor muscle weakness in subjects with chronic mild to moderate poststroke hemiparesis is caused by a decreased voluntary activation. DESIGN:: Forty community dwelling and ambulant men and women (mean age, 59.8 +/- 5.5 yrs) with residual he