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Systematic review of the healthcare cost of bronchopulmonary dysplasia

To determine the costs directly or indirectly related to bronchopulmonary dysplasia (BPD) in preterm infants. The secondary objective was to stratify the costs based on gestational age and/or birth weight. Systematic literature review. PubMed and Scopus were searched on 3 February 2020. Studies were selected based on eligibility criteria by two independent reviewers. Included studies were further

Genomic editing of metformin efficacy-associated genetic variants in SLC47A1 does not alter SLC47A1 expression

Several pharmacogenetics studies have identified an association between a greater metformin-dependent reduction in HbA1c levels and the minor A allele at rs2289669 in intron 10 of SLC47A1, encoding multidrug and toxin extrusion 1 (MATE1), a presumed metformin transporter. It is currently unknown if the rs2289669 locus is a cis-eQTL, which would validate its role as predictor of metformin efficacy.

Drought legacies on soil respiration and microbial community in a Mediterranean forest soil under different soil moisture and carbon inputs

Soil moisture can strongly affect the fate of soil organic carbon (C) during microbial decomposition, but the characterisation and prediction of the effects remain challenging, especially the long-term effects of drought history and its interaction with current levels of soil moisture. We investigated the legacy effects of drought on soil activity and microbial community composition and its intera

Sequential Neural Posterior and Likelihood Approximation

We introduce the sequential neural posterior and likelihood approximation (SNPLA) algorithm. SNPLA is a normalizing flows-based algorithm for inference in implicit models, and therefore is a simulation-based inference method that only requires simulations from a generative model. SNPLA avoids Markov chain Monte Carlo sampling and correction-steps of the parameter proposal function that are introdu

The interconnected influences of institutional and social embeddedness on processes of social innovation : A Polanyian perspective

Theorizing embeddedness requires sensitivity to the dynamic and multi-layered contexts that entrepreneurship is situated within. Social or network embeddedness offers explanation for how both social and for-profit entrepreneurs can leverage resources within their local environment. Institutional embeddedness is concerned with how the environment for entrepreneurship is shaped by social structures,

Quantitative powder diffraction using a (2 + 3) surface diffractometer and an area detector

X-ray diffractometers primarily designed for surface X-ray diffraction are often used to measure the diffraction from powders, textured materials and fiber-texture samples in 2θ scans. Unlike in high-energy powder diffraction, only a fraction of the powder rings is typically measured, and the data consist of many detector images across the 2θ range. Such diffractometers typically scan in direction

Towards an In-Depth Understanding of English-Swedish Translanguaging Pedagogy in Multilingual EFL Classrooms

This paper focuses on language practices in multilingual English as a foreign language (EFL) classrooms in lower-secondary education. Based in the Ethnography of Language Policy, it presents a case study of a lead teacher of EFL and a year-8 class in a large urban multilingual school in Sweden. The study aims to map and understand language practices used in this classroom as being part of a larger

Urokinase plasminogen activator mediates changes in human astrocytes modeling fragile X syndrome

The function of astrocytes intertwines with the extracellular matrix, whose neuron and glial cell-derived components shape neuronal plasticity. Astrocyte abnormalities have been reported in the brain of the mouse model for fragile X syndrome (FXS), the most common cause of inherited intellectual disability, and a monogenic cause of autism spectrum disorder. We compared human FXS and control astroc

Tourism revisited : The influence of digitalisation on tourism concepts

Information and communication technology (ICT) is ubiquitous in tourism and this changes not only tourists’ immediate behaviour, but also what tourism is. In this way, digitalisation is shifting perceptions of when tourism starts and ends, and how we can understand the term in principal ways. The aim of this working paper is to contribute to the debate about the consequences of today´s fast digita

Nature of Peace: An Interdisciplinary Enquiry into Research at the Intersection of Nature, Peace and Post-Conflict

The nexus between the environment, natural resources and (armed) violence has been researched since the end of the nineties, however major theoretical and empirical gaps still exists in research on the precise role of nature or the natural environment during post-conflict and/or peacebuilding, particularly in relation to those countries that have undergone internal armed conflict.This paper presen

Have we agreed on that? : Collective values in Community Grassroots Innovations

Grassroots Innovations (GI) have became a successful mechanism developed by the associative capacity of people that seek to provide solutions to their own problems relying on the values of solidarity and reciprocity while striving for social transformation (Smith and Seyfang, 2007; Seyfang and Haxeltine, 2012). However, GI still endure three challenges, namely: adaptation vs. transformation, local

NGOs, NGO-ing, and NGO-graphy in Serbia

Review article on anthropology of NGO research with point of departure on two ethnographic monographs on NGOs and civil society development in Serbia, with proposals for further NGO research.

The Long Awaited Trade Deal Between the EU and the UK - Expectations and Realities

At long last, the EU and the UK have struck an agreement on their new relationship defining future trade and cooperation across the Channel. However, expectations and realities do not always meet and so it is in the particular case here. The TCA is not an ordinary international trade agreement, as it contains distinct features which may disappoint those expecting a CETA-style deal. In addition, Br

Disaster-induced displacement in the Caribbean and the Pacific

People in Small Island Developing States are particularly vulnerable to displacement by disaster. Governments in the Caribbean and the Pacific need urgently to do more risk management and planning, rather than focusing almost exclusively on response and relocation.

The role of full-length apoE in clearance of Gram-negative bacteria and their endotoxins

ApoE is a well-known lipid-binding protein that plays a main role in the metabolism and transport of lipids. More recently, apoE-derived peptides have been shown to exert antimicrobial effects. Here, we investigated the antibacterial activity of apoE using in vitro assays, advanced imaging techniques, and in vivo mouse models. The formation of macromolecular complexes of apoE and endotoxins from G