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Characterisation of the genetic discordance between body mass index and type 2 diabetes: a phenome-wide analysis : No 111

Background and aims: Obesity is on the rise globally, and is a leading risk factor for T2D. However, it is very heterogeneous, with varying degrees of T2D risk within the same levels of BMI. Better classification may lead to improve outcomes of current preventive and therapeutic strategies. Moreover, by elucidating the mechanisms uncoupling obesity from T2D risk, new possible therapeutic targets m

Light, flight and the night : effect of ambient light and moon phase on flight activity of pteropodid bats

Fruit-feeding pteropodid bats roost under varying light conditions. Some roost in trees with high exposure to daylight (> 1000 lx), while others roost in dark caves (< 0.1 lx). To understand the effect of ambient light intensity and moon phase on flight activity, we examined flight times across five lunar cycles in three pteropodid species whose roosts differ in daylight exposure. We found signifi

Haemophilia early arthropathy detection with ultrasound and haemophilia joint health score in the moderate haemophilia (MoHem) study

Introduction: Detection of early arthropathy is crucial for the management of haemophilia, but data on moderate haemophilia are limited. Therefore, we evaluated joint health and treatment modalities in Nordic patients with moderate haemophilia A (MHA) and B (MHB). Aim: To explore and compare the Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) and Haemophilia Joint Health Score (H

Evaluating the Efficiency of Bike-Sharing Stations with Data Envelopment Analysis

This paper focuses on the efficiency evaluation of bike-sharing systems (BSSs) and develops an approach based on data envelopment analysis (DEA) to support the decisions regarding the performance evaluation of BSS stations. The proposed methodology is applied and tested for the Malmöbybike BSS in Malmö, Sweden. This was done by employing spatial analyses and data about the BSS usage trends as well

Endoscopic atomization of mesenchymal stromal cells : in vitro study for local cell therapy of the lungs

Background aims: Cell-based therapies of pulmonary diseases with mesenchymal stromal cells (MSCs) are increasingly under experimental investigation. In most of these, MSCs are administered intravenously or by direct intratracheal instillation. A parallel approach is to administer the cells into the lung by endoscopic atomization (spraying). In a previous study, the authors developed a flexible end

Universities and start-up creation by Ph.D. graduates : the role of scientific and social capital of academic laboratories

This paper investigates how the characteristics of university laboratories influence the propensity of Ph.D. students to entrepreneurship, and thus, contribute to the transfer of academic knowledge to society. As determinants of Ph.D. entrepreneurship, we focus on the lab scientific and social capital as well as on the business experience that Ph.D. students acquire during their training period. T

Authentic leadership theory : The case for and against

Scholarly and practitioner interest in the topic of authentic leadership has grown dramatically over the past two decades. Running parallel to this interest, however, have been a number of concerns regarding the conceptual and methodological underpinnings for research on the construct. In this exchange of letters, the cases for and against the current authentic leadership theory are made. Through

Revaccination with measles-mumps-rubella vaccine and hospitalization for infection in Denmark and Sweden – An interrupted time-series analysis

Background: In a previous cohort study of 4-year-old Danish children, revaccination with the live measles-mumps-rubella vaccine (MMR) was associated with a 16% reduction in the rate of hospitalization lasting two days or longer for non-measles-mumps-rubella infections. Aim: To examine if the introduction of revaccination with MMR at 4 years of age in Denmark (spring 2008) and at 7–9 years of age i

Pedagogical Translanguaging : Theoretical, Methodological and Empirical Perspectives

With increasing mobility of people across the world, there is a pressing need to develop evidence-based teaching practices that lead to high-quality education, which serves the needs of inclusive societies and social and epistemic justice. This book presents cutting-edge qualitative case-study research across a range of educational contexts, research-method contributions and theory-oriented chapte

A plasma protein biomarker strategy for detection of small intestinal neuroendocrine tumors

BACKGROUND: Small intestinal neuroendocrine tumors (SI-NETs) are difficult to diagnose in the early stage of disease. Current blood biomarkers such as chromogranin A (CgA) and 5-hydroxyindolacetic acid (5-HIAA) have low sensitivity and specificity. This is a first pre-planned interim analysis (NORDIC non-interventional, exploratory, EXPLAIN study (NCT02630654)). Its objective is to investigate if

The Arctic Carbon Cycle and Its Response to Changing Climate

Purpose of Review: The Arctic has experienced the most rapid change in climate of anywhere on Earth, and these changes are certain to drive changes in the carbon budget of the Arctic as vegetation changes, soils warm, fires become more frequent, and wetlands evolve as permafrost thaws. In this study, we review the extensive evidence for Arctic climate change and effects on the carbon cycle. In add

Maintenance of near normal bone mass and architecture in lethally irradiated female mice following adoptive transfer with as few as 750 purified hematopoietic stem cells

Total-body irradiation (TBI) followed by transfer of bone marrow cells from donors is routinely performed in immunology research and can be used to manipulate differentiation and/or function of bone cells. However, exposure to high-dose radiation can result in irreversible osteopenia, and transfer of heterogeneous cell populations can complicate interpretation of results. The goal of this research

Effects of a Four-day Spaceflight and Recombinant Human Growth Hormone on Cancellous Bone Microarchitecture in Femoral Head of Rapidly Growing Male Rats

Spaceflight results in reduced bone accrual and muscle atrophy in growing rodents. Some studies suggest that the detrimental effects of spaceflight are due, in part, to impaired growth hormone (GH) signaling. An experiment flown aboard STS-41 (October 6–10, 1990) evaluated the efficacy of recombinant human growth hormone (rhGH) in ameliorating the detrimental effects of spaceflight on the musculos