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Identification and characterization of CD8+ T-cells is important to determine their role in protecting and clearing viral infections. Here we provide details of the peptide-MHC (pMHC) tetramers-based approach to identify antigen-specific T-cells in human and murine samples. This method provides ex vivo quantifica-tion and functional characterization of T-cells reactive to specific viral antigens d
The operational map of the H3 Mach 6 blowdown wind tunnel, at the von Karman Institute for Fluid Dynamics (VKI), is extended towards lower Mach numbers with a new axisymmetric contoured nozzle to achieve Mach 5 testing conditions. Following the design, manufacturing, instrumentation and integration of the Mach 5 nozzle, an extensive commissioning campaign is initiated. The flow investigations rely
Incretin-based therapies are highly successful in combatting obesity and type 2 diabetes1. Yet both activation and inhibition of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) in combination with glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) activation have resulted in similar clinical outcomes, as demonstrated by the GIPR–GLP-1R co-agonist tirzepatide2 and AMG-133 (ref
This chapter foregrounds the fictional and factual relations that inform contemporary human-animal entanglements in manga and anime through the series One Piece. The epic journey of the ‘Straw Hat Crew’ in search for freedom and empowerment is characterised by its multispecies cast, subversive themes, and social commentary. However, by examining its depictions of gender and multispecies relations
Water resources are fundamental to life, ecosystems, and human development. In an era of climate change and increasing water scarcity, effective management of these resources is crucial, particularly in cold regions where glaciers and snow play vital roles in hydrological cycles. Understanding and accurately modelling these complex systems is essential for sustainable water resource management, cl
Non-volatile cryogenic memories are crucial for realizing energy-efficient and scaled quantum computing systems. In this letter, we evaluate the cryogenic performance of an HZO-based ferroelectric capacitor (FeCAP) with a compound semiconductor (InAs) as the bottom electrode. We demonstrate that near identical remnant polarization can be obtained at 14 K compared to room temperature by increasing
We propose a novel non-negative spherical relaxation for optimization problems over binary matrices with injectivity constraints, which in particular has applications in multi-matching and clustering. We relax respective binary matrix constraints to the (high-dimensional) non-negative sphere. To optimize our relaxed problem, we use a conditional power iteration method to iteratively improve the ob
Cooperative driving is a promising paradigm to improve traffic efficiency and safety. In congested traffic scenarios, such cooperation allows for safe maneuvering and driving with small inter-vehicle spatial gaps. The vehicles involved coordinate their movements in real-time and continuously update each other about their maneuver execution status by means of Vehicle-to-Everything (V2X) communicati
A salient aspect of the tropics is the prevalence of deep convection. It spans much of the depth of the troposphere, due to the positive buoyancy of cloudy updrafts warmed by latent heating from condensation. Cells of deep convection transfer heat, moisture and momentum to upper levels. They are crucial for the large-scale atmospheric circulation.Most precipitation from tropical systems is from de
Ice formation remains one of the most poorly represented microphysical processes in climate models. While primary ice production (PIP) parameterizations are known to have a large influence on the modeled cloud properties, the representation of secondary ice production (SIP) is incomplete and its corresponding impact is therefore largely unquantified. Furthermore, ice aggregation is another importa
To resolve the various types of biological ice nuclei (IN) with atmospheric models, an extension of the empirical parameterization (EP) is proposed to predict the active IN from multiple groups of primary biological aerosol particles (PBAPs). Our approach is to utilize coincident observations of PBAP sizes, concentrations, biological composition, and ice nucleating ability. The parameterization or
A key strategy to support the vision of a circular economy is to promote the consumption of more sustainable products. Both the EU and its Member States have therefore adopted several policies to support this objective. We review these policies and discuss their potential to trigger changes in consumer behaviour. The discussion is focused on five ‘points of intervention’: (1) regulatory choice edi
