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The surface-localized M protein of Streptococcus pyogenes is a major virulence factor that inhibits phagocytosis, as determined ex vivo. Because little is known about the role of M protein in vivo we analyzed the contribution of different M protein regions to virulence, using the fibrinogen (Fg)-binding M5 protein and a mouse model of acute invasive infection. This model was suitable, because M5 i

Low-dose ketamine administration mimics, both clinically and on gross neuroimaging, depersonalization disorder. The perceptual effects of ketamine may be due to secondary stimulation of glutamate release and lamotrigine, possibly by inhibited glutamate release, may reduce some of ketamine's so-called dissociative effects. However, lamotrigine does not seem to be useful in the treatment of deperson

The Wilms' tumour gene 1 (WT1) protein is highly expressed in most leukaemias. Co-expression of WT1 and the fusion protein AML1-ETO in mice rapidly induces acute myeloid leukaemia (AML). Mechanisms behind expression of WT1, as well as consequences thereof, are still unclear. Here, we report that the fusion protein BCR/ABL1 increases expression of WT1 mRNA and protein via the phosphatidylinositol-3

One implication of freedom of religion is that the State must accept a variety of religious beliefs and practices. Yet, not everything can be accepted. One way of dealing with such a conflict is to state that freedom of religion is absolute in so far that it does not infringe upon some other more important value. Another way is to limit what is considered ‘religious.’ Both these ways are insuffici

ABSTRACT: Seventeen patients with advanced Parkinson disease (PD) were treated with intrajejunal L-dopa infusion (IJL) and compared with a matched group of 9 patients (termed comparator [C]) not given IJL because of funding restriction by primary care trusts (PCTs) in the UK, although considered to be clinically eligible for IJL. Assessments were baseline and follow-up (6 months) with Hoehn and Ya

The method of nonequilibrium Greens functions allows for a spatial and energetical resolution of the electron current in Quantum Cascade Lasers. While scattering does not change the spatial position of carriers, the entire spatial evolution of charge can be attributed to coherent transport by complex wave functions. We discuss the hierarchy of transport models and derive the density matrix equatio

Purpose: To investigate the visibility of simulated lesions in digital breast tomosynthesis (BT) image volumes compared with 2D digital mammography (DM). Methods: Simulated lesions (masses and microcalcifications) were added to images of the same women acquired on a DM system (Mammomat Novation, Siemens) and a BT prototype. The same beam quality was used for the DM and BT acquisitions. The tota

Cross sections for electron energy transfer from the initial rotational state J' of the two lowest vibrational levels upsilon' = 0 and upsilon' = 1 of excited dimers Na2(A) to potassium atoms as described by Na2(A1Sigma(u)+, upsilon'J') + K(4S) --> Na2 (X1Sigma(g)+, upsilon''J'')+K(4P)+DeltaE have been examined by laser-induced fluorescence. A strong increase of the cross section by as much as an

Consider a quadratic form of a vector valued differentiable stationary Gaussian process. The crossing intensity of a fixed level depends on the joint correlation structure of the process and its derivative, but no simple exact form is known for the general case. We give the first and second terms in an asymptotic expansion, which is valid as the level tends to infinity, and show how to find higher