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Characterization of the Weimberg Pathway in Caulobacter crescentus

Caulobacter crescentus is a gram-negative bacterium that can utilize xylose as a substrate using the Weimberg pathway, which converts xylose to α-ketoglutarate in five steps without carbon loss. This is an interesting pathway for heterologous expression in other organisms in order to enable xylose utilization in biorefinery processes. C. crescentus was grown on xylose, arabinose and glucose, and m

Automaticity in the recognition of nonverbal emotional vocalizations

The ability to perceive the emotions of others is crucial for everyday social interactions. Important aspects of visual socioemotional processing, such as the recognition of facial expressions, are known to depend on largely automatic mechanisms. However, whether and how properties of automaticity extend to the auditory domain remains poorly understood. Here we ask if nonverbal auditory emotion re

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. We hypothesize that loss of ANGPTL4 function might improve glucose homeostasis and decrease risk of type 2 diabetes (T2D). We investigate protein-altering variants in ANGPTL4 among 58,124 participants in the DiscovEHR human genetics s

Accelerating delayed-acceptance Markov chain Monte Carlo algorithms

Delayed-acceptance Markov chain Monte Carlo (DA-MCMC) samples from a probability distribution, via a two-stages version of the Metropolis-Hastings algorithm, by combining the target distribution with a "surrogate" (i.e. an approximate and computationally cheaper version) of said distribution. DA-MCMC accelerates MCMC sampling in complex applications, while still targeting the exact distribution. W

Spring photosynthetic onset and net CO2 uptake in Alaska triggered by landscape thawing

The springtime transition to regional-scale onset of photosynthesis and net ecosystem carbon uptake in boreal and tundra ecosystems are linked to the soil freeze-thaw state. We present evidence from diagnostic and inversion models constrained by satellite fluorescence and airborne CO2 from 2012 to 2014 indicating the timing and magnitude of spring carbon uptake in Alaska correlates with landscape

Retrospective estimation of heart and lung doses in pediatric patients treated with spinal irradiation

Background and purpose: The purpose of this study was to investigate whether treatment information from medical records can be used to estimate radiation doses to heart and lungs retrospectively in pediatric patients receiving spinal irradiation with conventional posterior fields. Material and methods: An algorithm for retrospective dosimetry in children treated with spinal irradiation was develop

”Weibullarna” – lundahistoriker i takt med tiden

Martin (1835–1902) och sonen Lauritz Weibull (1873–1960) var båda professorer i historia vid Lunds universitet och kom – var och en på sitt sätt – att sätta sin prägel på svensk historieforskning. Båda var lokalhistoriskt intresserade och nordiskt orienterade och vände sig mot den inom svensk historievetenskap förhärskande svensk-nationella traditionen. Men det är Lauritz Weibull som inför eftervä

LRP10 genetic variants in familial Parkinson's disease and dementia with Lewy bodies : a genome-wide linkage and sequencing study

Background: Most patients with Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies do not carry mutations in known disease-causing genes. The aim of this study was to identify a novel gene implicated in the development of these disorders. Methods: Our study was done in three stages. First, we did genome-wide linkage analysis of an Italian family with dominantly inherit

Primary and secondary effects of climate variability on net ecosystem carbon exchange in an evergreen Eucalyptus forest

To understand the dynamics of ecosystem carbon cycling more than 10 years of eddy covariance data, measured over an evergreen, temperate, wet sclerophyll forest, were analysed and related to climate drivers on time scales ranging from hours to years. On hourly timescales we find that incoming shortwave radiation is the major meteorological driver of net ecosystem carbon exchange (NEE). Light use e

Integrating terrestrial and airborne lidar to calibrate a 3D canopy model of effective leaf area index

Terrestrial laser scanning (TLS) with the Echidna Validation Instrument (EVI) provides an effective and accurate method for calibrating multiple-return airborne laser scanning (ALS) point cloud distributions to map effective leaf area index (LAIe) and foliage profile within a 1-km diameter test site of mature eucalyptus forest at the Tumbarumba research site, New South Wales, Australia. Plot-based

Effect of spatial heterogeneity on the validation of remote sensing based GPP estimations

Satellite based remote sensing provides an efficient way to estimate carbon balance components over large spatial domains with acceptable temporal and spatial resolution. In the present study remote sensing based gross primary production (GPP) estimations were evaluated using data from a tall eddy-covariance flux tower, located over a heterogeneous agricultural landscape in Hungary. Four different

The evolutionary history of colour polymorphism in Ischnura damselflies

A major challenge in evolutionary biology consists of understanding how genetic and phenotypic variation is created and maintained. In this study, we investigated the origin(s) and evolutionary patterns of the female-limited colour polymorphism in ischnuran damselflies. These consist of the presence of one to three colour morphs: one androchrome morph with a coloration that is similar to the male

Digitala verktyg som pedagogiska hjälpmedel i föreläsningsrummet

Som ett led i vår egen fortbildning inom blended learning (blandade lärmiljöer), har vi valt att utveckla nya digitala verktyg inom en kurs som heter ”Introduktions- kurs i service management” (15 högskolepoäng, cirka 300 studenter). Målet med att införa nya digitala verktygen är att underlätta för studenterna att skapa förståelse för kurslitteraturen (teorier, begrepp och modeller) på kursens för

Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke : EPIC-CVD case-cohort study

Objective To investigate the association between alcohol consumption (at baseline and over lifetime) and non-fatal and fatal coronary heart disease (CHD) and stroke. Design Multicentre case-cohort study. Setting A study of cardiovascular disease (CVD) determinants within the European Prospective Investigation into Cancer and nutrition cohort (EPIC-CVD) from eight European countries. Participants 3

Allogeneic Stem Cell Transplantation from HLA-Mismatched Donors for Pediatric Patients with Acute Lymphoblastic Leukemia Treated According to the 2003 BFM and 2007 International BFM Studies : Impact of Disease Risk on Outcomes

Allogeneic hematopoietic stem cell transplantation (HSCT) is beneficial for pediatric patients with relapsed or (very) high-risk acute lymphoblastic leukemia (ALL) in remission. A total of 1115 consecutive patients were included in the ALL SCT 2003 BFM study and the ALL SCT 2007 I-BFM study and were stratified according to relapse risk (standard versus high versus very high risk of relapse) and do

Systemizing and the gender gap : examining academic achievement and perseverance in STEM

For years, a popular explanation for women choosing to abandon studies in science, technology, engineering, and mathematics (STEM) has been their lack of aptitude. This study challenged that notion by integrating theories of cognitive style, academic emotion, self-efficacy, and motivation to explain students’ academic achievement and perseverance in STEM when transitioning to college. A sample of

The Lower Ordovician Tøyen Shale succession in the Fågelsång-3 drill core, Scania, Sweden

The Ordovician Tøyen Shale Formation of the recently retrieved Fågelsång-3 drill core provides some important information on the graptolite biostratigraphy of the unit and its completeness in the region. The drill core reached downwards into the Kiaerograptus supremus Biozone of late Tremadocian age. Above a major fault zone, faunas with a number of specimens referred to Pseudophyllograptus densus

Making direct democracy work : a rational-actor perspective on the graphe paranomon in ancient Athens

The specific way the Athenians set up their democracy presents both theoretical and empirical challenges. Decisions were taken by majority vote in the Assembly. To keep politicians in line, the Athenians first used ostracism, which however was replaced by the graphe paranomon around 415 BCE. The latter provided that anybody who had made a proposal in the Assembly could be accused of having made an