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Damped trophic cascades driven by fishing in model marine ecosystems
The largest perturbation on upper trophic levels of many marine ecosystems stems from fishing. The reaction of the ecosystem goes beyond the trophic levels directly targeted by the fishery. This reaction has been described either as a change in slope of the overall size spectrum or as a trophic cascade triggered by the removal of top predators. Here we use a novel size- and trait-based model to ex
Characterization of oligomeric and kinetic properties of tomato thymidine kinase 1.
The gene encoding thymidine kinase 1 from tomato (toTK1) has in combination with azidothymidine (AZT) recently been proposed as a powerful suicide gene for anticancer gene therapy. The toTK1/AZT combination has been demonstrated to have several advantages for the treatment of glioblastomas because AZT can easily penetrate the blood-brain barrier and toTK1 can efficiently phosphorylate AZT and also
Platelet aggregation and clot formation in comatose survivors of cardiac arrest treated with induced hypothermia and dual platelet inhibition with aspirin and ticagrelor; a prospective observational study
Introduction: We conducted a prospective observational study in cardiac arrest survivors treated with mild induced hypothermia, evaluating different platelet function tests at hypo-and normothermia. We also investigated the relation between gastric emptying and vasodilator stimulated phosphoprotein (VASP). Methods: Comatose survivors of out of hospital cardiac arrest were included and divided into
Global and Local Health Governance: Civil society, human rights and hiv/aids
Fuel cell performance using a phosphonated polysulphone ionomer (PSUgPVPA) in the PEM cathode electrode
Inexpensive and environmentally friendly electrolyte polymers that can be operated at higher temperatures and drier conditions are highly interesting for PEM fuel cells for automotive, portable power and stationary electricity generation applications. In this study an ionomer based on polysulfone grafted with poly(vinylphosphonic acid) (PSUgPVPA) in the cathode Pt/C catalyst layer (CL) was electro
Opinions of legal professionals: Comparing child and adult witnesses' memory report capabilities
The opinions of legal professionals about child and adult witnesses might influence the likelihood that a case is allowed to proceed through the different stages of the legal process. With the aim of knowing the opinions of legal practitioners about child and adult witnesses, 84 legal professionals (Swedish police, prosecutors, and attorneys) were surveyed about their beliefs about child and adult
TO COMPARE MORTALITY IN 1175 PATIENTS WITH PSYCHOSIS AND THEIR FIRST DEGREE RELATIVES TO CORRESPONDING GROUPS OF MENTALLY HEALTHY CONTROLS
High intrapatient HIV-1 evolutionary rate is associated with CCR5-to-CXCR4 coreceptor switch
In approximately 70% of individuals infected with HIV-1 subtype B, the virus switches coreceptor use from exclusively CCR5 use (R5 virus) to either inclusion of or exclusively CXCR4 use (X4 virus) during infection. This switch is associated with an accelerated loss of CD4(+) T-cells and a faster progression to AIDS. Despite intensive research, the mechanisms responsible for coreceptor switch remai
Free to Trade? Commission Autonomy in Economic Partnership Agreement Negotiations
In this article, we suggest that the degree of (dis)unity - both between the member states (MS) in the Council and within the Commission - is a key factor in affecting the balance between Commission autonomy and MS control in international trade negotiations. We shed empirical light on this issue, and on the relative influence of MS and the Commission in general, through a case study of the Econom
Fast and sensitive time-multiplexed gas sensing of multiple lines using a miniature telecom diode laser between 1529 nm and 1565 nm
High-sensitive multi-species detection around 1550 nm using a modulated grating Y-branch, MG-Y, diode laser tunable between 1529 nm and 1565 nm is presented. The MG-Y diode laser is based on the Vernier effect of two modulated gratings, and exhibits quasi-continuous tuning over 36 nm. Multi-species detection is achieved by fast sequential scanning of single absorption lines of CH4, CO, C2H2, and C
Cysteine proteinase SpeB from Streptococcus pyogenes - a potent modifier of immunologically important host and bacterial proteins
Group A streptococcus (Streptococcus pyogenes) is an exclusively human pathogen that causes a wide spectrum of diseases ranging from pharyngitis, to impetigo, to toxic shock, to necrotizing fasciitis. The diversity of these disease states necessitates that S. pyogenes possess the ability to modulate both the innate and adaptive immune responses. SpeB, a cysteine proteinase, is the predominant secr
Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
BACKGROUND: Multiple laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. APPROACH: An expert committee compiled evidence-based recommendations for the use of laboratory analysis in patients with diabetes. A new system was developed to grade the overall quality o
A 4-component sex pheromone of the Chilean fruit leaf roller Proeulia auraria (Lepidoptera: Tortricidae)
The Chilean fruit leaf roller Proeulia auraria is a pest of economically important fruit species. Two compounds attractive to males have been identified as (E)-11-tetradecenyl acetate (E11-14:OAc) and (E)-11-tetradecenol (E11-14:OH) and are currently being used in Chile to monitor this species. Preliminary experiments carried out by our group suggested that the 2-compound mixture might not be opti
Transformation of admission interview to documentation for nursing practice.
The admission interview is usually the first structured meeting between patient and nurse. The interview serves as the basis for personalised nursing and care planning and is the starting point for the clinic’s documentation of the patient and his course of treatment. In this way, admission interviews constitute a basis for reporting by each nurse on the patient to nursing colleagues. This study e
Quality of life in children and adolescents with respiratory allergy, assessed with a generic and disease specific instrument.
Introduction: Respiratory allergic disorders like rhinitis and asthma are common conditions that not only affect target organs, but complicate the daily life of affected children and adolescents. Objectives: The aim of this study was to investigate the QoL (Quality of Life) in children with grass pollen allergy in and out of grass pollen season. Methods: We used the Pediatric Allergic Disea
Host Imprints on Bacterial Genomes-Rapid, Divergent Evolution in Individual Patients
Bacteria lose or gain genetic material and through selection, new variants become fixed in the population. Here we provide the first, genome-wide example of a single bacterial strain's evolution in different deliberately colonized patients and the surprising insight that hosts appear to personalize their microflora. By first obtaining the complete genome sequence of the prototype asymptomatic bact
Preovulatory progesterone concentration associates significantly to follicle number and LH concentration but not to pregnancy rate
Using data from a large prospective randomized controlled trial that evaluated the effect of recombinant LH (rLH) co-administration for ovarian stimulation, the present study assessed whether progesterone concentration on the day of human chorionic gonadotrophin (HCG) administration was associated with pregnancy outcome. Progesterone concentration was measured on stimulation day 1 and on the day o
STS-inspired design to meet the challenges of modern ageing. Welfare technology as a tool to promote user driven innovations or another way to keep older users hostage?
Abstract Older technology users and their integration into IT society have been on the research agenda since digitalization took off. Given the attempts to develop user-driven design, it is surprising that the appearance of technologies older people are provided with, or are the target group for, have not progressed. Now another political agenda, coined as “welfare technology”, is being launched i
The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: data from the European Prospective Investigation into Cancer and Nutrition.
Higher coffee intake has been purportedly related to a lower risk of liver cancer. However, it remains unclear whether this association may be accounted for by specific biological mechanisms.