Background Triptolide is an active natural product, which inhibits cell proliferation, induces cell apoptosis, suppresses tumor metastasis and improves the effect of other therapeutic treatments in several cancer cell lines by affecting multiple molecules and signaling pathways, such as caspases, heat-shock proteins, DNA damage and NF-ĸB. Purpose We investigated the effect of triptolide towards NF

The chapter addresses planning and designing by asking a threefold question: 1) How does talk about plans and designs mobilize specific understandings of the organization, its environment, future and purpose? 2) How do plans and designs have agency in organizations? 3) How do management concepts affect planning and designing? The chapter draws on various illustrative examples – from Babylonian met

Theoretical and experimental literature have provided mixed insights on the ability of financial markets to perfectly aggregate private information into asset prices. We conduct an experiment designed to benchmark information aggregation in markets. In our lab experiment, we randomly assign subjects to different institutional environments, either a market or a Becker–DeGroot–Marschak mechanism. We

This study contributes to debates on the efficacy of institutions in settler colonies by comparing the Cape Colony’s fiscal path to the experiences of Australia, New Zealand, and Canada. I find that the Cape’s fiscal trajectory was divergent. Agricultural and mining taxes were important surrogates of income taxes in other colonies, but the Cape’s narrow interests pushed for insulation from direct

Settings in social work may be associated with spatial stigma. This study uses the case of a highly stigmatised setting to investigate ways of ascribing positive characteristics to tainted contexts. Guided by symbolic interactionism, the aim is to analyse how residents in ‘wet’ eldercare facilities manage to view these in a positive light. Wet eldercare facilities are designed for older people wit

A novel interferometric technique to measure small wedge angle of transparent windows is proposed. The technique is based on the measurement of the shift of the interference pattern generated by two sheared copies of a laser beam after crossing the optical wedge. A simple lens is used to combine the two beams in their focal plane and measurements are taken for different shears. It is not necessary

The Burmese uḍhaya procedure represents a simplified calculation of the oblique ascension of the Sun that was used in Indian astronomy and astrology. The calculation has obvious connections with an Indian astronomical work, the Pauliśasiddhânta, and with works written by Brahmagupta. We investigate the Burrnese procedure mathematically to find out why it works.

The first great ruler to encourage the adoption of Western culture and technology throughout Siam was King Narai, who also had a passion for astronomy. He showed this by encouraging French and other Jesuit missionaries, some with astronomical interests and training, to settle in Siam from the early 1660s. One of these was Father Antoine Thomas, and he was the first European known to have carried o

Objectives: The aim of the research summarized in this thesis was to present a comprehensive view of the epidemiology of biopsy-confirmed GCA, investigate infection as a possible risk factor of GCA, and to assess the association of GCA with cancer and myocardial infarction.Methods: To establish incidence and prevalence, patients diagnosed with biopsy-confirmed GCA in Skåne, Sweden 1997–2019 were i

Lignin is one of the world's most abundant organic polymers, and 2-pyrone-4,6-dicarboxylate lactonase (LigI) catalyzes the hydrolysis of 2-pyrone-4,6-dicarboxylate (PDC) in the degradation of lignin. The pH has profound effects on enzyme catalysis and therefore we studied this in the context of LigI. We found that changes of the pH mostly affects surface residues, while the residues at the active

The dissertation aims to advance our understanding about the role of local industry structure in regional economic development. More specifically, it investigates how relatedness between local industries (i.e. similarities in what kind of knowledge industries use) contributes to and constrains regional economic development. Empirically, the dissertation investigates Swedish regional development in

Premise of research. Geochemical fingerprinting of fossil plants is a relatively new research field complementing morphological analyses and providing information for paleoenvironmental interpretations. Ginkgoales contains a single extant species but was diverse through the Mesozoic and is an excellent target for biochemical analyses. Methodology. Cuticles derived from fresh and fallen autumn leav

Human midbrain dopamine (DA) neurons are a heterogeneous group of cells that share a common neurotransmitter phenotype and are in close anatomical proximity but display different functions, sensitivity to degeneration, and axonal innervation targets. The A9 DA neuron subtype controls motor function and is primarily degenerated in Parkinson's disease (PD), whereas A10 neurons are largely unaffected

Background: A community-based intervention was implemented to improve maternal, child, and adolescent health practices, promote financial literacy and enhance livelihood opportunities for young people in marginalized communities. A hypothesis related to our intervention was that peer-led education sessions on health and nutrition in conjunction with community mobilization would change communities'