BACKGROUND: A blood-based test for the early detection of Parkinson's disease (PD) would be an important diagnostic tool and useful for patient selection when developing novel drugs or treatments for the disease.OBJECTIVE: Here, we aimed to identify potential biomarkers associated with PD.METHODS: We applied gene expression profiling to the study of peripheral blood from 75 healthy control subject

The study objective was to assess the efficacy, safety and feasibility of switching from levodopa/benserazide (LB) or levodopa/carbidopa (LC) to levodopa/carbidopa/entacapone (LCE) in Parkinson's disease (PD) patients with wearing-off. This was a multicenter, open-label, 6-week study; the primary outcome was success rate based on the patient-assessed Clinical Global Impression of Change (P-CGI-C).

BACKGROUND: Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens--aspirin plus extended-release dipyridamole (ASA-ERDP) versus clopidogrel.METHODS: In this double-blind, 2-by-2 factorial trial, we randomly assigned patients to receive 25 mg of aspirin plus 200 mg of extended-release dipyridamole twice daily

OBJECTIVE: Nonmotor symptoms are common in Parkinson's disease (PD). Health-related quality of life (HRQoL) is negatively affected by different factors, of which pain and sleep disturbances are important contributors. This study was performed to evaluate and describe subjective experiences of pain, sleeping patterns, and HRQoL in a cohort of PD patients with chronic pain.METHODS: A total of 45 par

The uptake of circular and sharing economy is accelerating, especially in cities and urban areas. Sharing is considered as one of the key strategies in circular economy, and a way to deliver social impact. This study explores the emergence of sharing business models in the real estate industry. The aim is to establish how novel business models are introduced in an urban development project. We emp

The global plastic and pollution crisis is intimately tied to climate breakdown and the extraction of fossil fuels. The ongoing negotiations over a global plastic treaty show why supply-side policy is urgently needed to address the root of this dual crisis in fossil fuels.

Metal-assisted chemical etching (MACE) is a cheap and scalable method that is commonly used to obtain silicon nano- or microwires but lacks spatial control. Herein, we present a synthesis method for producing vertical and highly periodic silicon microwires, using displacement Talbot lithography before wet etching with MACE. The functionalized periodic silicon microwires show 65% higher PEC perform

Svensk byggindustri genomgår en strukturomvandling och byggföretag väljer nuförtiden i stor utsträckning att använda sig av underentreprenörer i strävan efter organisatorisk flexibilitet. Genom etnografiska observationer och intervjuer från byggarbetsplatser analyserar jag hur arbetet organiseras inom två byggföretag och hur de resonerar i sin användning av underentreprenörer. Med utgångspunkt i o

The aim of this WaterWarmth project Work Package 6.1 report is to present a number of relevant frameworks available to analyse and/or assess the governance of current heating systems and future energy system innovation, in particular with a focus on aquathermal energy (AE) systems. At the basis of the report was a broad survey of the academic and other literature by project researchers on ways to

Introduction: Information about autonomic nervous system (ANS) activity may offer insights about atrial fibrillation (AF) progression and support personalized AF treatment but is not easily accessible from the ECG. In this study, we propose a new approach for ECG-based assessment of respiratory modulation in atrioventricular (AV) nodal refractory period and conduction delay. Methods: A 1-dimension

Background: Tracheal intubation is a high-risk procedure in the critically ill, with increased intubation failure rates and a high risk of other adverse events. Videolaryngoscopy might improve intubation outcomes in this population, but evidence remains conflicting, and its impact on adverse event rates is debated. Methods: This is a subanalysis of a large international prospective cohort of criti

The minority stress model has become a well-used framework to explain and analyse health among LGBTQ people, and specifically among transgender and gender-diverse people (TGD), when it is sometimes called ‘the gender minority stress model’. Scholars have argued the need for critical discussions about some of the assumptions underlying the gender minority stress model and how it has been used and d

Episodic memory retrieval is associated with the holistic neocortical reinstatement of all event information, an effect driven by hippocampal pattern completion. However, whether holistic reinstatement occurs, and whether hippocampal pattern completion continues to drive reinstatement, after a period of consolidation is unclear. Theories of systems consolidation predict either a time-variant or ti

In Schacter (2022), the author outlines the considerable progress that has been made in characterizing the impact of five (of the seven) sins of memory; specifically, transience, absentmindedness, misattribution, suggestibility, and persistence. As in his influential book, The Seven Sins of Memory: How the Mind Forgets and Remembers (Schacter, 2001, 2021), Schacter notes that this last sin of pers

In nearly all criminal justice systems, a defendant’s severe mental disorder can trigger special rules that excuse or exempt the defendant. Swedish criminal law adopts an alternative approach that considers all defendants to be equal in terms of accountability, or capacity for responsibility, and lacks any rules that excuse or exempt a defendant with a severe mental disorder or disability. This pa

Conservation biological control in agricultural landscapes aims to promote natural enemy populations to mitigate short and long-term pest damage on crops. However, natural enemy populations in agricultural landscapes typically rely on crop pests and non-pest prey populations resulting in complex trait- dependent ecological interactions. Such communities, of pests, non-pest prey, and natural enemie

In 1524, Petrus Apianus published two closely related works—one the Latin Cosmographicus liber, aimed at an educated audience of international readers, and the other, Ein kunstlich Instrument, a shorter, more practical book for those who could read German but had no Latin. Both books nevertheless make use of most of the same instruments, including Apianus’ early volvelles. Most of these instrument