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We have re-refined the X-ray structure of the heme site in cytochrome c553, supplementing the crystallographic data with quantum chemical geometry optimizations, instead of the molecular mechanics force field used in standard crystallographic refinement. By comparing the resulting structure, obtained using medium-resolution data (170 pm), with an atomic-resolution structure (95 pm) of the same pro
Studies using selective agonists have suggested that the contractile effect of extracellular nucleotides, such as ATP and UTP, in blood vessels is mediated mainly by P2X1 receptors with a smaller contribution of P2Y receptors while the mitogenic effect is mediated by P2Y (P2Y1, P2Y2, P2Y4, and P2Y6) receptors with no effect of P2X1 receptors. This indicates a difference in P2 receptor expression b
The purpose of this study was to investigate the reliability of repeated measurements and a possible learning or tiring process in single-limb stabilometry and one-leg hop test. An additional purpose was to study the correlation between different stabilometric variables. Seventy-five healthy subjects were examined twice with a median interval of 7 d, and with three consecutive measurements on each
The mass production of integrated circuits for digital electronics has made CMOS technology the most frequently used IC process today. Thanks to the large production volume, CMOS has increasingly become the most cost efficient technology of choice, and the fast development of small, high speed CMOS devices has made the technology feasible for many RF applications. However, as the transistor featur
In his fetishist argument, Michael Smith raises an important question: What is the content of the motivational states that constitute moral motivation? Although the argument has been widely discussed, this question has not received the attention it deserves. In the present paper, I use Smith's argument as a point of departure for a discussion of how advocates of externalism as regards moral judgem
Guanine nucleotide-binding proteins (G-proteins) are known to act as important modulators of insulin release from the islets of Langerhans. We have recently found that the deoxynojirimycin-derivative emiglitate, a recognized inhibitor of intestinal alpha-glucosidehydrolase activity, is a powerful inhibitor of glucose-induced insulin release. With the use of isolated mouse islets the present invest
Study Design. Experimental study. Objectives. To compare two devices for measuring cervical range of motion, a three-dimensional ultrasound motion device (Zebris) and a gravity-reference goniometer (Myrin). Summary of Background Data. Assessment of cervical range of motion is used to evaluate the effect of different treatments, determine impairment, and ascertain the relationship between neck diso
The gastrointestinal mucosa is one of the most rapidly proliferating tissues in the body, and serves as a barrier to luminal bacteria and toxins. Enteral nutrition, luminal fiber and probiotics are of crucial importance for the integrity of this barrier. We examined the potential beneficial effects of lactobacilli and fiber on methotrexate-induced enterocolitis and radiation-induced intestinal inj
OBJECTIVE: To describe the epidemiology of and risk factors for severe chickenpox in Guinea- Bissau. METHODS: A prospective household study in a semiurban area of the capital. Severity was assessed by number of pox, fever response and presence of pneumonia. Severity was compared for the first case in a house, that is, the index case, and the secondary cases infected at home. RESULT: We identified
This essay examines the extent to which scholarly work offers new insights into the problematique of conflict prevention and whether there are any significant alterations in the international management of conflict. The existing literature generally exhibits a number of methodological and theoretical weaknesses, which makes conflict prevention less useful as an analytical concept. In practice, sta
Abstract is not available
Evidence-based practice presupposes evidence-based decision-making. In the debate it is argued that a social work fashioned after evidence should be more rational, less authoritarian and built on scientific knowledge, respect and ethics. Yet the empirical evidence that this idea works is weak. In fact the difficulties met during efforts to implement evidence could be a sound reaction. Indeed diffi
Purpose of review This review addresses recently reported evidence for alternative cellular pathways for haematopoietic stem cell lineage commitment. Recent findings Using various approaches, several laboratories suggested the existence of adult as well as foetal multipotent progenitor cells with combined B cell, T cell and granulocyte/macrophage potential, but little or no megakaryocyte/erythroid
