The intestinal lamina propria (LP) contains distinct subsets of classical dendritic cells (cDC), each playing key non-redundant roles in intestinal immune homeostasis. Here, we show that glycoprotein 2 (GP2), a GPI-anchored protein and receptor for bacterial type-I fimbriae, is selectively expressed by CD103+CD11b+ cDC in the murine small intestine (SI). GP2 expression was induced on CD103+CD11b+

The adult immune system consists of cells that emerged at various times during ontogeny. We aimed to define the relationship between developmental origin and composition of the adult B cell pool during unperturbed hematopoiesis. Lineage tracing stratified murine adult B cells based on the timing of output, revealing that a substantial portion originated within a restricted neonatal window. In addi

Individuals who sleep poorly report spending more time mind wandering during the day. However, past research has relied on self-report measures of sleep or measured mind wandering during laboratory tasks, which prevents generalization to everyday contexts. We used ambulatory assessments to examine the relations between several features of sleep (duration, fragmentation, and disturbances) and mind

Given the disproportionate burden of childhood diarrhea deaths in Nigeria, this study assessed the prevalence and predictors of the disease and the uptake of ORS and zinc supplementation as treatments in a population-based national survey. Cross-sectional data from the 2018 Nigeria Demographic Health Survey were used. A log-Poisson regression was used to estimate the relative risks (RR) for the in

Here, we aimed to develop and validate a fully automated artificial intelligence (AI)-based method for the detection and quantification of suspected prostate tumour/local recurrence, lymph node metastases, and bone metastases from [18F]PSMA-1007 positron emission tomography-computed tomography (PET-CT) images. Images from 660 patients were included. Segmentations by one expert reader were ground t

Mutated Nucleophosmin 1 (NPM1) is the most common genetic alteration in acute myeloid leukemia (AML), found in approximately 30% of cases. Although mutations in this gene are considered favorable according to current risk stratification guidelines, a large fraction of patients will suffer from relapse, demonstrating the urgent need for new treatment options. Therefore, we aimed to identify cell su

The rate of cancer patients will continue to increase in the coming decades. Additionally, new treatments will continue to emerge. The increased survival rates and the anti-tumour medications used will without doubt contribute to an increased rate of patients with oncological emergencies. Patients with oncologic emergencies will foremost seek care at an emergency department, but physicians at othe

This study explores when and why entrepreneurs choose entrepreneurial learning strategies that emphasize exploration or exploitation. Most studies have focused on explaining the different characteristics of exploration and exploitation, their performance implications, whether they are complementarities or substitutes and how particular organizational structures can support their coexistence. We ap

Det här kapitlet undersöker fenomenet influencers från ett arbetslivsperspektiv. Den kulturanalytiska utgångspunkten är ett intresse för hur personer som försörjer sig som influencers i sociala medier själva upplever arbetet, det liv som arbetet innebär och de hälsorisker det medför. Forskning om influencers har ofta haft ett annat fokus, såsom ett marknadsföringsperspektiv som beskriver hur föret

To make the content of moving images and audio-visual media available to a visually impaired audience, a sighted interpreter can provide audio description (AD). AD is a verbal description of visual events, aiming to increase the accessibility of visual information and to provide a visually impaired audience with a richer and more detailed understanding and experience of, for instance, films. To ac