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Evolution of HIV-1 coreceptor use in relation to pathogenesis

Popular Abstract in Swedish Humant immunbrist virus (HIV) bryter långsamt ner kroppens immunförsvar. Sjukdomen AIDS uppstår när den HIV infekterade personens immunförsvar är så pass försvagat att kroppen inte längre kan bekämpa infektioner som en frisk individ inte blir sjuk av. Världshälsoorganisationen, WHO, uppskattar att det idag lever omkring 40 miljoner människor i världen smittade med HIV. HIV-1 uses the coreceptors CCR5 and/or CXCR4 in addition to CD4 to enter the host cell. CCR5-using HIV-1 (R5 phenotype) appears to transmit infection and usually dominates the early stages of disease. Evolution of HIV-1 coreceptor use is usually described as the acquisition of CXCR4-using virus (X4 or R5X4 phenotype), and is linked to accelerated disease progression. However, the switch to CXCR4 u

Combined pseudo-merohedral twinning, non-crystallographic symmetry and pseudo-translation in a monoclinic crystal form of the gamma delta T-cell ligand T10

T10 is a non-classical class Ib-like major histocompatibility complex (MHC) cell-surface antigen which binds directly to certain gammadelta T-cell receptors in the absence of any exogenous and endogenous ligands, such as peculiar lipids or glycolipids. The crystal structure at 2.5 Angstrom resolution of murine T10 was determined by molecular replacement using data from an almost perfectly twinned

Millian Superiorities

Suppose one sets up a sequence of less-and-less valuable objects such that each object in the sequence is only marginally worse than its immediate predecessor. Could one in this way arrive at something that is dramatically inferior to the point of departure? It has been claimed that if there is a radical value difference between the objects at each end of the sequence, then at some point there mus

A force allocation strategy for dynamic positioning

A force allocation strategy used in connection with dynamic positioning of ships and semi-submersibels is presented. The strategy dynamically allocates force, and in case of azimuth thrusters - force directions, to a set of thrusters. The strategy handles n thrusters (n greater than or equal to 2) in an arbitrary configuration. The decision making of the strategy is based on minimum power consumpt

Patients with suspected acute coronary syndrome in a university hospital emergency department: an observational study.

Background: Improved diagnostics in suspected acute coronary syndrome (ACS) are considered to be needed. To help clarify the current situation and the improvement potential, judged risk in the emergency department (ED) and outcome were analyzed among patients with suspected ACS at a university hospital. Methods: 157 consecutive patients with symptoms of ACS were included at the ED during 10 days.

Distal migration of stent-grafts after endovascular repair of abdominal aortic aneurysms

PURPOSE: To analyze patients after endovascular repair of abdominal aortic aneurysm (AAA) with respect to distal migration of stent-grafts and its underlying causes. MATERIALS AND METHODS: Sixty-five patients underwent endovascular repair between January 1994 and February 1997. There were seven women and 58 men, with a mean age of 71 years (range, 51-84 years). Three patients died in the periopera

Retinal examination intervals in diabetic patients on diet treatment only

PURPOSE: The aim of the present study was to examine whether type 2 diabetic patients with good metabolic control achieved on diet treatment only, developed sight-threatening retinopathy during a four-year follow-up period. METHODS: A retrospective four-year follow-up study was carried out including all diabetic patients on diet treatment only, registered at the out-patient clinic at the Departmen

On quantification of error and uncertainty in two-zone models used in fire safety design

The error in smoke transport models have mainly been analyzed with qualitative approaches till date. The results make it difficult to perform a quantitative assessment of the model error in fire safety design applications. Even if a model has a substantial model error, it can be a very useful tool, as long as the designer is aware of the errors and the uncertainties in the predictions. This paper

Importance of obtaining independent measures of insulin secretion and insulin sensitivity during the same test - Results with the Botnia clamp

OBJECTIVE - To validate and apply a method for independent assessment of insulin secretion and insulin sensitivity (S-l) during file same test that is, an intravenous glucose tolerance test followed by a euglycemic-hyperinsulinemic clamp, also called the Botnia clamp. This test was then applied to nondiabetic subjects with (FH+)and without (FH-) a first-degree family history of diabetes. RESEARCH

Bjälklag på jord : grundläggningsdjup

Grundläggning med "platta på mark" eller riktigare "bjälklag på jord" kan ske med kantförstyvad platta eller med platta och grundmurar. Enligt Svensk Byggnorm 67 är grundläggningsdjupet enligt huvudregeln 0,25 m. Grundläggningsdjup måste emellertid knytas till ett stort antal förutsättningar. Genom tillgång till datorberäkningsmetoder och stora datorer har det blivit möjligt att noga teoretiskt st

Biomedical and atmospheric applications of optical spectroscopy in scattering media

Popular Abstract in Swedish Den här doktorsavhandlingen handlar om vad som händer när ljus lyser genom spridande material. Det viktigaste användningsområdet är inom medicin, men även tillämpningar inom atmosfärsmätningar berörs. Metoderna som är beskrivs är dessutom så generella att de kan användas för alla typer av spridande material, till exempel olika livsmedel, papper, plast, färg och rök. I eSpectroscopic analysis of scattering media is difficult because the effective path length of the light is non-trivial to predict when photons are scattered many times. The main area of research for such conditions is biological tissues, which scatter light because of variations of the refractive index on the cellular level. In order to analyze tissues to diagnose diseases, or predict doses during,

Review of Cecilia Wejryd, Läsarna som brände böcker. Erik Jansson och erikjansarna i 1840-talets Sverige. Uppsala 2002

Denna fakultetsopposition ifrågasätter om bokbränningen, och inte snarare syndfrihetsläran var det centrala i erikjansismen, även om framställningen av bokbränningens progression här är en förtjänst. Wejryd använder skickligt Wilsons schismmodell, med tonvikt på den mobiliserande aktören, den utlösande faktorn och kyrkans sociala kontroll, kombinerad med Hirschmans termer exit (olämpligt översatt

Short communication: An overview of the findings of the Combustion Behaviour of Upholstered Furniture project

This paper gives an overview of the Combustion Behaviour of Upholstered Furniture (CBUF) project. The work described is the collective effort of 11 CBUF partners, laboratories, universities, industries, in eight countries. It became possible to do this research thanks to the European Commission's interest in the burning behaviour of upholstered furniture and their willingness to sponsor this effor