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Multifocal visual evoked potentials-a method study of responses from small sectors of the visual field.

Objective: A method study of the mfVEP technique to establish a standardised way to identify stable response components from small areas in all parts of the visual field and a test-retest reliability study. Methods: MfVEP was recorded from 26 healthy volunteers. Results: Two response components could be clearly identified. The latencies corresponded to those of the traditional VEP response (N75 an

Image analysis study of mould susceptibility of spruce and larch wood dried or heat-treated at different temperatures

In this study, mould growth on wood was investigated by image analysis. The studied parameters were drying and heat-treatment temperatures (20-210°C), original and resawn surface and different wood species (spruce and larch). Small specimens—some of which were inoculated with a spore suspension—were stored under humid conditions and photographed once a week. Mould growth was assessed by image anal

Preservation of antimicrobial properties of complement peptide C3a - from invertebrates to humans.

The human anaphylatoxin peptide C3a, generated during complement activation, exerts antimicrobial effects. Phylogenetic analysis, sequence analyses, and structural modeling studies paired with antimicrobial assays of peptides from known C3a sequences showed that, in particular in vertebrate C3a, crucial structural determinants governing antimicrobial activity have been conserved during the evoluti

C-erbB-2 expression does not predict response to docetaxel or sequential methotrexate and 5-fluorouracil in advanced breast cancer

Breast cancer patients with c-erbB-2-positive tumours seem to benefit from anthracycline-based adjuvant chemotherapy. The predictive value of c-erbB-2 for taxane sensitivity is not yet clear. The purpose of this study was to assess whether c-erbB-2 expression is associated with clinical sensitivity to docetaxel (T) or sequential methotrexate and 5-fluorouracil (MF). A total of 283 patients with me

The Internet, public spheres, and political communication: Dispersion and deliberation

The theme of the Internet and the public sphere now has a permanent place on research agendas and in intellectual inquiry; it is entering the mainstream of Political communication studies. The first part of this presentation briefly pulls together key elements in the public sphere perspective, underscoring three main analytic dimensions: the structural, the representational, and the interactional.

A potential double role of anti-Lewis X antibodies in Helicobacter pylori-associated gastroduodenal diseases

In this study, we found Lewis X (Le(X)) determinants on 68% of Helicobacter pylori isolates from patients with chronic gastroduodenal diseases. Anti-Le(X) IgG were detected more frequently in the sera from dyspeptic children and adults (45 and 46%), with or without proved (culture) H. pylori infection, than in the sera from healthy individuals (14%, and 25%). In contrast, the prevalence of anti-Le

Enzymatic characterization of lipid-based drug delivery systems

The present work introduces a simple and robust in vitro method for enzymatic characterisation of surface properties of lipid dispersions in aqueous media. The initial lipolysis rate in biorelevant media, using pancreatic lipase and a self-microemulsifying formulation (SMEDDS) containing digestible lipids as substrate, was determined. The impact of incorporating two sparingly water soluble model d

Desperately seeking sameness: the processes and pleasures of identification in women’s diary blog reading

The Internet offers a plethora of venues for autobiographical self-representation: webcams, personal websites, blogs. There is much research on self-representation online, whereas very little research has focused on the consumption of online self-representation. This article focuses on the act of reading diary blogs. Who are the actual readers of a specific blog and what values do they place on th

TNF-alpha and IFN-gamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro

In Fanconi anemia (FA) C mice tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) have key roles in the pathogenesis of bone marrow failure. In FA subjects TNF-alpha was found to be increased in the serum and overproduced by patient-derived B-cell lines. In acquired aplastic anemia, a disease in which, similarly to FA, marrow failure occurs, TNF-alpha and IFN-gamma act as late

Expansion of the BioCyc collection of pathway/genome databases to 160 genomes

The BioCyc database collection is a set of 160 pathway/genome databases (PGDBs) for most eukaryotic and prokaryotic species whose genomes have been completely sequenced to date. Each PGDB in the BioCyc collection describes the genome and predicted metabolic network of a single organism, inferred from the MetaCyc database, which is a reference source on metabolic pathways from multiple organisms. I

Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophils.

Proteinase 3 (PR3) is found in granules of all nentrophils but also on the plasma membrane of a subset of nentrophils (mPR3). CD177, another neutrophil protein, also displays a bimodal surface expression. In this study, we have investigated the coexpression of these two molecules, as well as the effect of cell activation on their surface expression. We can show that CD177 is expressed on the same

Insulin secretion and insulin sensitivity in relation to fasting glucose in healthy subjects.

OBJECTIVE - This study evaluated insulin secretion and insulin sensitivity in healthy subjects with normal fasting glucose. RESEARCH DESIGN AND METHODS - A total of 148 healthy women (aged 53-70 years) underwent a glucose-dependent arginine stimulation test and a 2-h euglycemic-hyperinsulinemic clamp. In the arginine test, arginine (5 g) was injected intravenously under baseline (fasting) conditio

Protein D, the immunoglobulin D-binding protein of Haemophilus influenzae, is a lipoprotein

Protein D is an immunoglobulin D-binding membrane protein exposed on the surface of the gram-negative bacterium Haemophilus influenzae. Results reported here indicate that protein D is a lipoprotein. The protein is apparently synthesized as a precursor with an 18-residue-long signal sequence modified by the covalent attachment of both ester-linked and amide-linked palmitate to the cysteine residue

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX

Background Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in which the risk of disease is influenced by complex genetic and environmental contributions. Alleles of HLA-DRB1, IRF5, and STAT4 are established susceptibility genes; there is strong evidence for the existence of additional risk loci. Methods We genotyped more than 500,000 single-nucleotide polymorphisms (SNPs)

Thermal radiation and effects on transport processes in solid oxide fuel cells

The major processes significant for solid oxide fuel cell (SOFC) characteristics are species transport, electrochemical reactions, electronic and ionic transport, heat transfer, and temperature distribution. Of particular significance is an accurate determination of the temperature distribution because material properties, chemical kinetics, and transport properties depend heavily on the temperatu

Cardiac and ventilatory responses to apneic exercise

This study was to elucidate the physiological effects of dynamic apneas, as performed as a discipline in breath-hold diving for recreational or competitive purposes. Therefore, cardiovascular and respiratory effects of apneas with simultaneously initiated exercise were investigated in ten trained breath-hold divers. They performed maximum duration apneas with face immersion (26 degrees C) under re

Correlated morphological and colour differences among females of the damselfly Ischnura elegans

1. The female-limited colour polymorphic damselfly Ischnura elegans has proven to be an interesting study organism both as an example of female sexual polymorphism, and in the context of the evolution of colour polymorphism, as a model of speciation processes. 2. Previous research suggests the existence of correlations between colour morph and other phenotypic traits, and the different female morp