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Dipeptidyl peptidase-4 (DPP-4) inhibition is a glucose-lowering medication for type 2 diabetes. It works through stimulation of insulin secretion and inhibition of glucagon secretion in a glucose-dependent manner, resulting in lowered fasting and postprandial glycemia with low risk of hypoglycemia. As impaired insulin secretion and augmented glucagon secretion are key factors underlying hyperglyce

Primary immune thrombocytopenia is an autoimmune disease associated with a reduced peripheral blood platelet count. The phenotype is variable with some patients suffering no bleeding whilst others have severe bleeding which may be fatal. Variability in clinical behaviour and treatment responses reflects its complex underlying pathophysiology. Historically the management has relied heavily on immun

This study aims to explore how physicians make sense of and give meaning to their decision-making during obstetric emergencies. Childbirth is considered safe in the wealthiest parts of the world. However, variations in both intervention rates and delivery outcomes have been found between countries and between maternity units of the same country. Interventions can prevent neonatal and maternal morb

The relationship between slavery and capitalism has become a renewed topic of debate, yet scholars have not been able to agree on a definition of capitalism. In this article I first clear up some misconceptions and situate the debate in the Marxian tradition from which it arose. I argue that while non-Marxian accounts of capitalism fail to explain the key social transformations that have accompani

Historians and economists have increasingly identified capitalist patterns of behavior among antebellum slave owners, yet no consensus has emerged about the explanation for this finding. I argue that US slave owners were driven to behave like capitalists in part because of their dependence on credit. The ability of creditors to seize the land and slaves of insolvent debtors generated selection pre

This paper outlines a classical-Marxian model of the antebellum US economy. The model assumes that the mobility of capital tended to equalize the rate of profit between North and South, whilst land rents were minimized by an expanding frontier. Under these conditions slave prices are the capitalized present value of the excess surplus value produced by slaves. This excess surplus value arose becau

Following the immense impact of the COVID-19 pandemic on health and everyday lives world-wide, people's fear of COVID-19 has been studied in a number of settings using the Fear of COVID scale. In Sweden, virus-preventing strategies have differed from comparable countries, with low use of formal lock-down procedures. It is crucial to study correlates of non-compliance with COVID-19 recommendations,

Attempts to imagine a shift beyond capitalism often tend to fixate on the terms of the old socialist calculation debate: plan versus market. At its deepest level, though, capitalism is not fundamentally a matter of the distribution of goods, for underlying this is the possession of land. In thinking about the end of capitalism it is thus useful to return to the question of its origin as the second

The design of a primary electron beam facility at CERN is described. The study has been carried out within the framework of the wider Physics Beyond Colliders study. It re-enables the Super Proton Synchrotron (SPS) as an electron accelerator, and leverages the development invested in Compact Linear Collider (CLIC) technology for its injector and as anaccelerator research and development infrastruc

In this Expression of Interest, we propose a primary electron beam facility with the main motivations being (i) dark sector experiments, and (ii) to enable a suite of development projects in acceleration technology. We also present a detailed description of an experiment, the Light Dark Matter eXperiment, LDMX, which could make use of this facility to probe thermal dark matter over a majority of t

Although access-based business models such as product rental hold promise for contributing to sustainable production and consumption, their diffusion is hindered by a lack of consumer acceptance. In order for rental models to resonate with consumers, they must be designed and communicated in a way that aligns with consumers’ needs. While many studies have addressed business model design, few have

Background: Obstructive sleep apnea (OSA) is associated with dyslipidemia. However, the effects of continuous positive airway pressure (CPAP) treatment on lipid profiles are unclear. Methods: PubMed/Medline, Embase and Cochrane were searched up to July 2021. Randomized controlled trials (RCTs) of CPAP versus controls with ≥4 weeks treatment and reported pre-and post-intervention lipid profiles wer

This article approaches the intelligence dimension of Sweden’s arms exports by going back to three governmental decisions, taken in 1914, 1935 and 1971 respectively, all of which have been pivotal to both the Swedish government’s involvement in arms exports and the emergence of government institutions handling the intelligence associated with this export. The article shows that a significant amoun

Cognitive function is a crucial determinant of human capital. The Lancet Commission (2020) has recognized air pollution as a risk factor for dementia. However, the scientific evidence on the impact of air pollution on cognitive outcomes across the life course and across different income settings, with varying levels of air pollution, needs further exploration. A systematic review was conducted, us