Objectives: Older/elderly patients with acute lymphoblastic leukemia (ALL) are poorly represented in clinical trials. Methods: Using Swedish national leukemia registries, we investigated disease/patient characteristics, treatment choices, outcome, and the impact of an age-adapted protocol (introduced in 2009) in this population-based study of patients aged 55-85 years, diagnosed with ALL 2005-2012

Results on the production of π±, K±, p(p), Λ(Λ), Ξ- (Ξ+) and Ω- (Ω+) at midrapidity (/y/ < 0.5) as a function of multiplicity in √ s = 7 TeV pp collisions are reported. Transverse momentum distributions and integrated yields are compared to expectations from statistical hadronization models along with results from different colliding systems and center-of-mass energies. The evolution of spectral s

Background: Slipped capital femoral epiphysis (SCFE) is the most common hip disorder in children 9-15 years old. This is a population-based study in Sweden presenting the epidemiology for SCFE. Methods: In a prospective cohort study, we analysed pre- and postoperative radiographs, medical records for all children treated for SCFE in Sweden 2007-2013, demographic data, severity of slip and surgical

Event generators play a crucial role in the exploration of LHC physics. This presentation summarizes news and plans for the three general-purpose pp generators HERWIG, PYTHIA and SHERPA, as well as briefer notes on a few other generators. Common themes, such as the matching and merging between matrix elements and parton showers, are highlighted. Other topics include a historical introduction, from

The jet energy scale (JES) uncertainty is estimated using different methods at different pT ranges. In-situ techniques exploiting the pT balance between a jet and a reference object (e.g. Z or gamma) are used at lower pT, but at very high pT (> 2.5 TeV) there is not enough statistics for such in-situ techniques. A low JES uncertainty at high-pT is important in several searches for new phenomena, e

Background: To evaluate the effect of a smoking-, alcohol- or combined-cessation intervention starting shortly before surgery and lasting 6 weeks on overall complications after radical cystectomy. Secondary objectives are to examine the effect on types and grades of complications, smoking cessation and alcohol cessation, length of hospital stay, health-related quality of life and return to work or

In this contribution we analyse double vector meson production in photon - hadron (γh) interactions at pp/pA/AA collisions and present predictions for ρρ, J/ψJ/ψ and ρJ/ψ production considering the double scattering mechanism. We estimate the total cross sections and compare our results with the predictions for double vector meson production in γγ interactions at hadronic c olliders. Our results d

We present a trinification-based grand unified theory incorporating a global SU(3)F family symmetry, that after spontaneous symmetry breaking leads to a left-right symmetric model. In addition to unification of gauge couplings, the model unifies Yukawa interactions and contains equivalent representations in the scalar and fermion sectors at high energy scales. Considering the minimal low-energy sc

Aims/hypothesis: P-element induced Wimpy testis (PIWI)-interacting RNAs (piRNAs) are small non-coding RNAs that interact with PIWI proteins and guide them to silence transposable elements. They are abundantly expressed in germline cells and play key roles in spermatogenesis. There is mounting evidence that piRNAs are also present in somatic cells, where they may accomplish additional regulatory ta

We study the initial-state interactions (non-coherence) and nuclear shadowing (coherence) effects in the Drell-Yan pair production process in p+Pb collisions at the LHC energies. The analysis of the nuclear suppression, RpA < 1, has been performed in the color dipole approach in the large coherence length approximation. The Z0 boson contribution relevant at large dilepton invariant masses has been

Triple-negative breast cancer (TNBC) patients commonly exhibit poor prognosis and high relapse after treatment, but there remains a lack of biomarkers and effective targeted therapies for this disease. Here, we report evidence highlighting the cell-cycle–related kinase CDK7 as a driver and candidate therapeutic target in TNBC. Using publicly available transcriptomic data from a collated set of TNB

BACKGROUND: Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating condition resulting from a sustained lack of oxygen during birth. The interest in identifying a relevant biomarker of HIE has thrown into limelight the role of protein S100B as a clinical diagnostic marker of hypoxic brain damage in neonates.AIMS: To evaluate the diagnostic value of protein S100B, measured in umbilical cor

The problem of finding the controller that optimizes the expected H2-norm of an uncertain system is solved in closed form for a class of problems including such signal processing applications as feedforward design, channel equalization, noise cancellation etc. The method uses covariance information on model uncertainty and does therefore match information obtainable from standard system identifica

Background: The aim of this study was to explore trends in treatment with antipsychotic medication in Swedish dementia care in nursing homes as reported in the most recent empirical studies on the topic, and to relate these trends to directives from the national authorities. Methods: The study included two scoping review studies based on searches of electronic databases as well as the Swedish dire

BACKGROUND—: Myeloid cells are central to atherosclerotic lesion development and vulnerable plaque formation. Impaired ability of arterial phagocytes to uptake apoptotic cells (efferocytosis), promotes lesion growth and establishment of a necrotic core. The transcription factor Interferon Regulatory Factor (IRF)-5 is an important modulator of myeloid function and programming. We sought to investig

Background: At birth, infants' lungs are fluid-filled. For newborns to have a successful transition, this fluid must be replaced by air to enable effective breathing. Some infants are judged to have inadequate breathing at birth and are resuscitated with positive pressure ventilation (PPV). Giving prolonged (sustained) inflations at the start of PPV may help clear lung fluid and establish gas volu

Mass transfer in infinite parallel-plate dialyzers with co-flow between sample and detector streams is discussed for three different theoretical models. Analytical solutions with coupled diffusion and membrane transfer equations were obtained for plug flow in both channels. The finite-difference approximation method was used to obtain numerical solutions for a laminar-flow regime. Results obtained

Simultaneous optimisation of several criteria is an important and interesting subject. Even the standard H2-case is non-trivial. The problem is here treated for the general MIMO case for two conflicting objectives (the results directly generalise to several performance measures). A seminorm D2 is introduced to describe the situation. The state-space solution technique in [Khargonekar and Rotea, 19