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Defining Excellence : The First Core Set of Quality Indicators for the European Paediatric Surgical Audit on Hirschsprung's Disease Care

Aim: This study aimed to develop a universally applicable core set of quality indicators for Hirschsprung's disease care through a consensus-driven process, to standardise and improve care quality across Europe. Methods: A modified Delphi method was used to achieve consensus among healthcare professionals (HPs) and patient representatives (PRs) across Europe. Participants completed three rounds of

Affordances and Limitations of Translanguaging and Writing Tools : A Study of Emergent Multilingual Students' Writing in EFL

Multilingual students writing in English as a foreign/second language has been a major topic in research for many years (see Leung & Valdés for overview). This topic is particularly relevant in Sweden, as reports suggest that students who are speakers of a language other than Swedish (LOTS) in the home have a lower grade average after 9 years of compulsory schooling (Skolinspektionen, 2010; Sk

Balancing inflammation : the specific roles of serum amyloid A proteins in sterile and infectious diseases

Serum Amyloid A (SAA) proteins are acute-phase reactants with critical roles in sterile and bacterial inflammation. Through in vitro and in vivo experiments, we demonstrate that SAA proteins amplify cytokine and chemokine responses during sterile inflammation and enhance bacterial clearance in infectious conditions. Mechanistically, SAA proteins augment NF-κB signaling, driving pro and anti-infl

Regeneration of dimethyl carbonate and purification of 5-hydroxymethylfurfural used in a biphasic dehydration process through activated carbon adsorption and evaporation

The production of 5-hydroxymethylfurfural (HMF) is an important process for a future sustainable plastic industry. Hence many processes were developed to produce HMF, however, HMF recovery and solvent recyclability are limiting steps for the process development. Therefore, In this study, granulated activated carbon (GAC) was investigated as a purification step of HMF produced from fructose in a bi

Flexiblare finansregler med tveksam effekt

Många EU-länder kämpar med svaga offentliga finanser och i stora euroländer som Frankrike och Italien är den offentliga skulden över 100 procent av BNP. Trots strikta finanspolitiska regler har få länder lyckats hålla sina statsfinanser i schack – inte ens Tyskland. År 2024 reviderades reglerna i förhoppningen att det skall leda till mer robusta offentliga finanser i framtiden. Frågan är: löser de

Soluble cerebral Aβ protofibrils link Aβ plaque pathology to changes in CSF Aβ42/Aβ40 ratios, neurofilament light and tau in Alzheimer’s disease model mice

The Aβ42/Aβ40 ratio in the cerebrospinal fluid (CSF) and the concentrations of neurofilament light (NfL) and total tau (t-tau) are changed in the early stages of Alzheimer’s disease (AD)1, but their neurobiological correlates are not entirely understood. Here, we used 5xFAD transgenic mice to investigate the associations between these CSF biomarkers and measures of cerebral Aβ, including Aβ42/Aβ40

Heart rate response and recovery in cycle exercise testing : normal values and association with mortality

Aims. Chronotropic incompetence and impaired heart rate (HR) recovery are related to mortality. Guidelines lack specific reference values for HR recovery. We defined normal values and studied blunted HR response and recovery and mortality risk. Methods and results. We included 9917 subjects (45% females) aged 18–85 years who performed a cycle exercise test. We defined normal values for peak HR, HR

The place of Bulgarian and Russian in post-Talmian motion event typology : A Holistic Spatial Semantics Analysis

The traditional Talmian binary typology of satellite-framed vs. verb-framed languages has proven to be insufficient for showing the diversity across the world’s languages. One approach within post-Talmian motion typology follows Holistic Spatial Semantics, which has been applied to languages like Swedish, French, Thai and Telugu, but not to Slavic languages. This motivates the present research. We

Spatial QRS-T angle can indicate presence of myocardial fibrosis in pediatric and young adult patients with hypertrophic cardiomyopathy

Background: Myocardial fibrosis, expressed as late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR), is an important risk factor for malignant cardiac events in hypertrophic cardiomyopathy (HCM). However, CMR is not easily available, expensive, also needing intravenous access and contrast. Objective: To determine if derived vectorcardiographic spatial QRS-T angles, an aspec

Prognostic relevance of CD163+ immune cells in patients with metastatic breast cancer

Metastatic breast cancer (MBC) is generally considered an incurable disease and even though new treatments are available, the median survival is approximately three years. The introduction of immune therapies for MBC highlights the importance of the immune system in cancer progression and treatment. CD163+ anti-inflammatory myeloid cells, including tumor associated macrophages (TAMs), are known to

The struggle of leadership work: Three interactional challenges in mobilizing actors to commit to future action

Although it is widely recognized that leadership concerns organizing future actions and mobilizing organizational actors to pursue them, our understanding of how this is accomplished in situated work interactions is relatively limited. Recent ethnographic studies have focused on leadership work resulting in the emergence of direction. This study explores the efforts involved in attempting to mobilAlthough it is widely recognized that leadership concerns organizing future actions and mobilizing organizational actors to pursue them, our understanding of how this is accomplished in situated work interactions is relatively limited. Recent ethnographic studies have focused on leadership work resulting in the emergence of direction. This study explores the efforts involved in attempting to mobil

Knivkontakt: mot en kirurgisk karriär

"Knivkontakt" av Hagelsteen & Frost - din guide till en framgångsrik ST i kirurgiska specialiteter. Lär dig navigera i kirurgvärlden, ta ansvar för ditt lärande, hantera utmaningar och utveckla rätt mindset. Praktiska tips från erfarna kirurger i fickformat!Finns nu hos alla nätbokhandlare. Kliniker som önskar köpa större volymer till rabatterat pris kan kontakta författarna.

Modelling the Evolution of Species’ Ranges

Att arter har begränsade geografiska utbredningsområden beror ofta på en begränsad förmåga att anpassa sig till de miljöförhållanden som råder utanför arternas utbredningsgränser. På grund av pågående klimatförändringar kan dock de miljöförhållanden som råder inom arters nuvarande utbredningsområden komma att ändras inom den närmaste framtiden. För att undgå utrotning kommer därför många populatioThe fact that species have limited ranges is often due to a limited ability to adapt to the environmental conditions that occur outside their geographic ranges. However, due to ongoing climate change, the environmental conditions within species’ geographic ranges may change in the near-future. To avoid extinction, many populations therefore need to migrate to new areas and/or adapt to the new cond

Acute unilateral vestibulopathy and corticosteroid treatment - A randomized placebo-controlled double-blind trial

BACKGROUND: The efficacy of corticosteroids for treating acute vestibular neuritis, or acute unilateral vestibulopathy (AUVP), remains controversial.OBJECTIVE: This study aimed to evaluate whether corticosteroids improve vestibular function and reduce symptoms in both acute and chronic phases of AUVP.METHODS: This randomized, placebo-controlled, double-blind trial included patients with AUVP (ages

Unconventional gap structures and the intermediate mixed state: A vortex lattice study of the noncentrosymmetric superconductor BiPd

We report on neutron scattering measurements on the vortex lattice of the noncentrosymmetric superconductor BiPd. We observe the existence of the intermediate mixed state, a region where Meissner and vortex lattice phases coexist, which is a feature of low type-II superconductors. Following this, we obtain an estimate of the value of using the extended London model. Finally, we find that the tempe

Transplacental transfer efficiency of perfluoroalkyl substances (PFAS) after long-term exposure to highly contaminated drinking water : a study in the Ronneby Mother-Child Cohort

BACKGROUND: Perfluoroalkyl substances (PFAS) are stable chemicals used in various applications. PFAS exposure has been associated with lower birth weight and immunological effects in children, and limited evidence further suggests adverse neurodevelopmental effects. Previous studies show that PFAS cross the placental barrier during pregnancy leading to prenatal exposure of the fetus. Research on t

Problem gambling among elite ice hockey players in Sweden – elevated prevalence among male, but not female athletes

ABSTRACTObjectivesAn emerging body of research reveals a heightened risk of gambling problems among elite athletes, particularly among males, but these studies often suffer from small sample sizes and lack diverse representation across sports and groups. This study aimed to investigate gambling problems and their correlates among elite male and female ice hockey players in Sweden’s top leagues.Met

Evaluation of 3D-printed plastics for Ultra-High Vacuum applications : Outgassing, and residual gas analysis

The demand for cost- and time-effective and customizable components for High Vacuum (HV) and Ultra-High Vacuum (UHV) systems has prompted exploration into the application of 3D-printing technology. This study investigates the viability of utilizing 3D-printed plastics in UHV environments by evaluating their outgassing properties. An extensive evaluation of 3D-printing materials was carried out, hi

Toxicity of carbon nanomaterials : A model to predict ROS production from easily measurable surface characteristics

Toxicity pathways of engineered carbon nanomaterials, which have many and diverse industrial applications, include oxidative stress primarily due to the generation of reactive oxygen species (ROS). This study on 13 carbon black, 6 Graphene nanoplatelets (GNP), and 3 nanodiamond materials identified physicochemical properties driving their ROS production. ROS production was cross-validated using di