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The cytokine TGFβ1 induces epidermal Langerhans cell (LC) differentiation from human precursors, an effect mediated through BMPR1a/ALK3 signaling, as revealed from ectopic expression and receptor inhibition studies. Whether TGFβ1‒BMPR1a signaling is required for LC differentiation in vivo remained incompletely understood. We found that TGFβ1-deficient mice show defective perinatal expansion and di

BACKGROUND: Asthma is characterised by an aggravated immune response to respiratory viral infections. This phenomenon is a clinically well-recognised driver of acute exacerbations, but how different phenotypes of asthma respond immunologically to viruses is unclear. OBJECTIVES: To describe the association between different phenotypes and severity of asthma and bronchial epithelial immune responses

This article updates our previous Stroke Gene Panels (SGP) from 2017. Online Mendelian Inheritance in Man and PubMed were searched. We divided detected genes into two SGP groups, SGP1: genes reported in at least one person with stroke and associated with one or more clinical subgroups: large artery atherosclerotic, large artery non-atherosclerotic (tortuosity, dolichoectasia, aneurysm, non-atheros

At present, the Global Stratotype Section and Point (GSSP) for the base of the Bartonian remains the only GSSP of the Paleogene System to be defined by the International Subcommission on Paleogene Stratigraphy (ISPS) and the International Commission on Stratigraphy (ICS). Here, we present the results of an integrated, high-resolution study of calcareous plankton and benthic foraminifera biostratig

BACKGROUND: A significant proportion of patients with ST-segment– elevation myocardial infarction (MI) have no standard modifiable cardiovascular risk factors (SMuRFs) and have unexpected worse 30-day outcomes compared with those with SMuRFs. The aim of this article is to examine outcomes of patients with non–ST- segment– elevation MI in the absence of SMuRFs. METHODS AND RESULTS: Presenting featu

The atomic layer deposition of HfO2on a TiO2(101) surface from tetrakis(dimethylamido)hafnium and water is investigated using a combination of in situ vacuum X-ray photoelectron spectroscopy (XPS) and time-resolved ambient pressure XPS. Precursor pressures and surface temperature are tuned as to map the space state of the deposition. In the initial stages of ALD, a reaction mechanism based on diss

Serious outcomes as stroke, arrythmia and death are relatively frequent in patients presenting with dizziness. Within 30 days almost one in five patients re-attended the ED due to dizziness and 2,8% needed ED evaluation due to a fall. Decision support tools to help identify serious conditions and predict preventable falls in ED patients with dizziness are needed.

Fibrillar protein aggregates are a hallmark of a range of human disorders, from prion diseases to dementias, but are also encountered in several functional contexts. Yet, the fundamental links between protein assembly mechanisms and their functional or pathological roles have remained elusive. Here, we analyze the aggregation kinetics of a large set of proteins that self-assemble by a nucleated-gr

- Specialist supervision of junior health care providers was feasible via the HoloLens 2- Some clinical procedures could potentially be performed with virtual supervision- Mixed reality has the potential to improve specialist involvement and senior decision making, particularly in out of office hours and in the prehospital setting.- A feasibility study using HoloLens 2 in a clinical setting is a r

Background: Multiple system atrophy (MSA) is a rare and aggressive neurodegenerative disease that typically leads to death 6 to 10 years after symptom onset. The rapid evolution renders it crucial to understand the general disease progression and factors affecting the disease course. Objectives: The aims of this study were to develop a novel disease-progression model to estimate a population-level

This thesis studies two families of methods for finding zeros of finite sums of monotone operators, the first being variance-reduced stochastic gradient (VRSG) methods. This is a large family of algorithms that use random sampling to improve the convergence rate compared to more traditional approaches. We examine the optimal sampling distributions and their interaction with the epoch length. Speci

Nudging has been discussed in the context of policy and public health, but not so much within healthcare. This scoping review aimed to assess the empirical evidence on how nudging techniques can be used to affect the behavior of healthcare professionals (HCPs) in clinical settings.A systematic database search was conducted for the period January 2010–December 2020 using the PRISMA extension for ScNudging has been discussed in the context of policy and public health, but not so much within healthcare. This scoping review aimed to assess the empirical evidence on how nudging techniques can be used to affect the behavior of healthcare professionals (HCPs) in clinical settings. A systematic database search was conducted for the period January 2010-December 2020 using the PRISMA extension for S

The European Copernicus programme plans to install a constellation of multiple polar orbiting satellites (Copernicus Anthropogenic CO2 Monitoring Mission, CO2M mission) for observing atmospheric CO2 content with the aim to estimate fossil fuel CO2 emissions. We explore the impact of potential CO2M observations of column-averaged CO2 (XCO2), nitrogen dioxide (NO2), and aerosols in a 200 × 200 km2 d