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Parameterization-induced uncertainties and impacts of crop management harmonization in a global gridded crop model ensemble
Global gridded crop models (GGCMs) combine agronomic or plant growth models with gridded spatial input data to estimate spatially explicit crop yields and agricultural externalities at the global scale. Differences in GGCM outputs arise from the use of different biophysical models, setups, and input data. GGCM ensembles are frequently employed to bracket uncertainties in impact studies without inv
An extraterrestrial trigger for the mid-Ordovician ice age : Dust from the breakup of the L-chondrite parent body
The breakup of the L-chondrite parent body in the asteroid belt 466 million years (Ma) ago still delivers almost a third of all meteorites falling on Earth. Our new extraterrestrial chromite and 3He data for Ordovician sediments show that the breakup took place just at the onset of a major, eustatic sea level fall previously attributed to an Ordovician ice age. Shortly after the breakup, the flux
Accumulated neighbourhood deprivation and coronary heart disease : A nationwide cohort study from Sweden
Objective Neighbourhood deprivation is a recognised predictor of coronary heart disease (CHD). The overall aim was to investigate if accumulated exposure to neighbourhood deprivation resulted in higher odds of CHD. Design This is a longitudinal cohort study. Models based on repeated assessments of neighbourhood deprivation as well as single-point-in-time assessments were compared. Setting Sweden.
Clinically assessed knee joint laxity as a predictor for reconstruction after an ACL injury
Impact of systemic therapy on circulating leukocyte populations in patients with metastatic breast cancer
Tumors affect the immune system, locally and systemically. The frequencies of specific circulating immune cell populations correlate with disease progression as well as prognosis of the patients. Although largely neglected, conventional antitumoral therapies often possess immunomodulatory properties and affect the levels of specific immune cell populations. Most information, however, derive from a
Clusterwise Peak Detection and Filtering Based on Spatial Distribution to Efficiently Mine Mass Spectrometry Imaging Data
Mass spectrometry imaging (MSI) has the potential to reveal the localization of thousands of biomolecules such as metabolites and lipids in tissue sections. The increase in both mass and spatial resolution of today's instruments brings on considerable challenges in terms of data processing; accurately extracting meaningful signals from the large data sets generated by MSI without losing informatio
Rhinovirus-induced IFNβ expression is NFκB-dependent and regulated by the macrophage microenvironment
Macrophages play an important role in asthma pathogenesis both in the inflammatory and resolution phase of the disease. Macrophages can acquire different polarisation states dependent on their microenvironment. It is yet unclear through which mechanism the microenvironment affects the anti-viral response in macrophages. We hypothesized that the macrophage microenvironment regulates rhinovirus-indu
Variation in Sedation and Neuromuscular Blockade Regimens on Outcome After Cardiac Arrest
OBJECTIVES: Sedation and neuromuscular blockade protocols in patients undergoing targeted temperature management after cardiac arrest address patient discomfort and manage shivering. These protocols vary widely between centers and may affect outcomes. DESIGN: Consecutive patients admitted to 20 centers after resuscitation from cardiac arrest were prospectively entered into the International Cardia
Searching for WT1 target genes in leukemic cell lines
Endoscopic submucosal dissection of 301 large colorectal neoplasias : outcome and learning curve from a specialized center in Europe
Background and study aims Endoscopic submucosal dissection (ESD) allows en bloc resection of large colorectal lesions but ESD experience is limited outside Asia. This study evaluated implementation of ESD in the treatment of colorectal neoplasia in a Western center. Patients and methods Three hundred and one cases of colorectal ESD (173 rectal and 128 colonic lesions) were retrospectively evaluate
The role of cellular RNA processing functions in Human papillomavirus type 16 gene regulation
Infections with Human papillomavirus type 16 (HPV16) is the most the most common, sexually transferred and is responsible for genital warts, cervical cancers and a growing number of head and neck cancers. Knowledge about how HPV16 interacts with the infected cell to regulate its gene expression is essential for therapeutic development. Here, we show that the viral E5 protein which may contribute t
Chronic Inflammation and Atherosclerosis
Inflammation is a vital response and necessary for maintaining homeostasis. Inflammation protects against tissue damage and pathogens-but is also one of the main driving forces of the atherosclerotic plaque progression. How and why the inflammatory response is initiated in the atherosclerotic disease is not fully known, but evidence suggests modified lipids as potential antigens activating the imm
New synthetic approaches to biofuels from lignocellulosic biomass
Lignocellulose from terrestrial plant biomass is abundant and contains polymeric carbohydrates and lignin; both recognized as attractive renewable feedstocks for energy, chemicals and materials as alternatives to fossils to meet the targets for future sustainable development. Liquid biofuels are particularly important renewable commodities because of the vast infrastructure already in place to use
Religion and domesticity
Catholics and Protestants assumed that God instituted the family and that it had certain spiritual functions to perform. In 1985, Colleen McDannell addressed changes in Christian perceptions of the home and family in nineteenth-century America. This chapter focuses on Christian ideas of the home and family in nineteenth-century Europe and touches on similar themes to those discussed by McDannell,
Recension av Johan Sundeen "Att tjäna är människans storhet. Idéhistoriska essäer om Birger Forell" (2017) och Johan Sundeen "En utsträckt hand till masseländets land. Antinazisten och Tysklandsvännen Birger Forell 1893-1958" (2018)
Integrating behavioral and geospatial data on the timeline : Towards new dimensions of analysis
Studies of spatial behavior increasingly rely on a combination of audiovisual and geospatial recordings. So far, however, few analytical environments have offered opportunities for integrated and expedient annotation and analysis of the two. Here we report the first study aimed at integrating geospatial data in ELAN, a tool developed for time-aligned annotation of audiovisual media. By calibrating
Telomere Biology and Vascular Aging
Telomeres form the end segment of the DNA helix and shorten with every cell division until getting so short that the cell stops dividing and will undergo programmed cell death (apoptosis). Research has supported the view that telomere length could be regarded as a marker of biological aging, even if methodological problems could interfere with the interpretation of telomere length in cross-section
CPAP and health-related quality of life in adults with coronary artery disease and nonsleepy obstructive sleep apnea in the RICCADSA trial
Study Objectives: To determine the effect of continuous positive airway pressure (CPAP) treatment on health-related quality of life (HRQoL) in adults with coronary artery disease (CAD) and nonsleepy obstructive sleep apnea (OSA). Methods: This was a secondary outcome analysis of the RICCADSA trial, conducted in Sweden between 2005 and 2013. Adults with CAD, nonsleepy OSA (apnea-hypopnea index [AHI
Hip-related groin pain, patient characteristics and patient-reported outcomes in patients referred to tertiary care due to longstanding hip and groin pain : A cross-sectional study
Background: Due to advances in hip arthroscopy, the number of surgical procedures has increased dramatically. The diagnostic challenge in patients with longstanding hip and groin pain, as well as the increasing number of hip arthroscopies, may lead to a higher number of patients referred to tertiary care for consideration for surgery. Therefore, the aims were: 1) to describe the prevalence of hip-