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Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes
Incretin-based therapies are highly successful in combatting obesity and type 2 diabetes1. Yet both activation and inhibition of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) in combination with glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) activation have resulted in similar clinical outcomes, as demonstrated by the GIPR–GLP-1R co-agonist tirzepatide2 and AMG-133 (ref
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Fat and the digital space : Mediated body shapes
“I Want Meat!” : Gendered Eating and Anthropocentric Fighting in One Piece
This chapter foregrounds the fictional and factual relations that inform contemporary human-animal entanglements in manga and anime through the series One Piece. The epic journey of the ‘Straw Hat Crew’ in search for freedom and empowerment is characterised by its multispecies cast, subversive themes, and social commentary. However, by examining its depictions of gender and multispecies relations
Improving hydrological modelling in cold regions using satellite remote sensing and machine learning techniques
Water resources are fundamental to life, ecosystems, and human development. In an era of climate change and increasing water scarcity, effective management of these resources is crucial, particularly in cold regions where glaciers and snow play vital roles in hydrological cycles. Understanding and accurately modelling these complex systems is essential for sustainable water resource management, cl
The dark side of the room : Dialogues of light and shadows in the Roman domestic space
Illuminating the Digital Past : Analyzing Social Complexity in Ancient Spaces with Light Simulations
Visual Experience in a Pompeian Domestic Space : Analysis Using Virtual Reality–Based Eye Tracking and GIS
Dialoghi tra luce e spazio sociale nella casa romana
Cryogenic Ferroelectricity of HZO Capacitors on a III-V Semiconductor
Non-volatile cryogenic memories are crucial for realizing energy-efficient and scaled quantum computing systems. In this letter, we evaluate the cryogenic performance of an HZO-based ferroelectric capacitor (FeCAP) with a compound semiconductor (InAs) as the bottom electrode. We demonstrate that near identical remnant polarization can be obtained at 14 K compared to room temperature by increasing
Unreliable V2X communication in cooperative driving : Safety times for emergency braking
Cooperative driving is a promising paradigm to improve traffic efficiency and safety. In congested traffic scenarios, such cooperation allows for safe maneuvering and driving with small inter-vehicle spatial gaps. The vehicles involved coordinate their movements in real-time and continuously update each other about their maneuver execution status by means of Vehicle-to-Everything (V2X) communicati
Physical Meteorology
A salient aspect of the tropics is the prevalence of deep convection. It spans much of the depth of the troposphere, due to the positive buoyancy of cloudy updrafts warmed by latent heating from condensation. Cells of deep convection transfer heat, moisture and momentum to upper levels. They are crucial for the large-scale atmospheric circulation.Most precipitation from tropical systems is from de
Observations of natural snow and its fragmentation on Jungfraujoch
Sensitivity of Arctic Clouds to Ice Microphysical Processes in the NorESM2 Climate Model
Ice formation remains one of the most poorly represented microphysical processes in climate models. While primary ice production (PIP) parameterizations are known to have a large influence on the modeled cloud properties, the representation of secondary ice production (SIP) is incomplete and its corresponding impact is therefore largely unquantified. Furthermore, ice aggregation is another importa
Empirical formulation for multiple groups of primary biological ice nucleating particles from field observations over Amazonia
To resolve the various types of biological ice nuclei (IN) with atmospheric models, an extension of the empirical parameterization (EP) is proposed to predict the active IN from multiple groups of primary biological aerosol particles (PBAPs). Our approach is to utilize coincident observations of PBAP sizes, concentrations, biological composition, and ice nucleating ability. The parameterization or
How Can We Persuade Consumers to Purchase More Sustainable Products? A Review of European Legal Developments
A key strategy to support the vision of a circular economy is to promote the consumption of more sustainable products. Both the EU and its Member States have therefore adopted several policies to support this objective. We review these policies and discuss their potential to trigger changes in consumer behaviour. The discussion is focused on five ‘points of intervention’: (1) regulatory choice edi
What is Right to Repair (R2r) and How Can it be Realised through Legal Interventions?
Serum ARGS-aggrecan in a phase 2 clinical trial targeting osteoarthritis
OBJECTIVE: To monitor serum concentrations of the aggrecan alanine-arginine-glycine-serine (ARGS) neoepitope in a clinical trial of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-5 inhibition as disease-modifying therapy of knee osteoarthritis, and to investigate relationships between reduction in ARGS and change in cartilage thickness, knee-related pain and function. DESITo monitor serum concentrations of the aggrecan alanine-arginine-glycine-serine (ARGS) neoepitope in a clinical trial of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-5 inhibition as disease-modifying therapy of knee osteoarthritis, and to investigate relationships between reduction in ARGS and change in cartilage thickness, knee-related pain and function.DesignROCCELLA t
Multiplex genome editing eliminates the Warburg Effect without impacting growth rate in mammalian cells
The Warburg effect is ubiquitous in proliferative mammalian cells, including cancer cells, but poses challenges for biopharmaceutical production, as lactate accumulation inhibits cell growth and protein production. Previous efforts to eliminate lactate production via knockout have failed in mammalian bioprocessing since lactate dehydrogenase has proven essential. However, here we eliminated the Wa