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Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification
Parkinson's disease (PD) is characterized by proteinaceous aggregates named Lewy Bodies and Lewy Neurites containing α-synuclein fibrils. The underlying aggregation mechanism of this protein is dominated by a secondary process at mildly acidic pH, as in endosomes and other organelles. This effect manifests as a strong acceleration of the aggregation in the presence of seeds and a weak dependence o
Förord till den svenska utgåvan
Kata Dalström : agitatorn som gick sin egen väg
Fångna i begreppen? Revolution, tid och politik i svensk socialistisk press 1917-1924
En ny social bostadspolitik? Nej, men en bra början.
S-rapporten, ”en ny social bostadspolitik” levererar en bra problemanalys och flera goda målbeskrivningar men deras förslag orkar inte helt i mål, menar Ingemar Bengtsson, Universitetslektor vid Avdelningen för Fastighetsvetenskap, Lunds Universitet. Ingemar Bengtsson ifrågasätter gruppens allmänna strävan att samhället ska öka den samlade bostadskonsumtionen och efterlyser i följande kommentar me
Den eleganta cyklisten : Cykling, mode och kvinnlighet i sekelskiftets svenska och danska damtidningar
The elegant cyclist: Cycling, fashion and femininity in Swedish and Danish women’s magazines at the turn of the 20th century.At the turn of the 20th century the new sport of cycling was endowed with femininity in Scandinavian ladies’ magazines. An analysis of the magazines Idun, Svensk Damtidning, Damernes Blad and Hjemmet between 1890 and the 1910s show that both Swedish and Danish magazines appe
Demons of Urban Reform. Early European Witch Trials and Criminal Justice, 1430-1530
Witchcraft, madness, society and religion in early modern Germany: a ship of fools
Taking Turns : On the Relation between Crime, Sin (& Vice)
"I got annoyed that no one wanted to talk about retreat room as religious"
Rites for ‘Nones’
Contemporary Landscape of Being and Time: : Comparative Analysis of Samuel Beckett’s Waiting for Godot and Martin Amis’s Dead Babies
The Inverted Relationship : Constitutive Theory of Law and the Enforcement of Orthodoxy in Book XVI of the Theodosian Code
This paper focuses on the question if, and if so how, the Theodosian Code, the first legal codification of the Roman Empire and its devoted to religion Book XVI, facilitated the formation and enforcement of the concept of orthodoxy and its boundaries. It uses the propositions of the Cognitive Science of Religion to advance a new understanding of the shift towards orthodoxy, as the process in which
Montelukast, a CysLT1 receptor antagonist, reduces colon cancer stemness and tumor burden in a mouse xenograft model of human colon cancer
Inflammation is implicated in the etiology of sporadic colon cancer (CC), which is one of the leading causes of cancer-related deaths worldwide. Here, we report that inhibition of the inflammatory receptor CysLT1 through its antagonist, montelukast, is beneficial in minimizing stemness in CC and thereby minimizing tumor growth in a mouse xenograft model of human colon cancer. Upon treatment with m
Experimental and modeling study of liquid fuel injection and combustion in diesel engines with a common rail injection system
Fuel injection is one of the most important processes in compression-ignition internal combustion engines owing to its significant impact on the exhaust emissions and thermal efficiency. In this study, experiments were carried out to investigate the influence of injection pressure and injection timing on the temporal evolution of the injection rate and injection duration in a specially designed ex
Critical steps for computational inference of the 3′-end of novel alleles of immunoglobulin heavy chain variable genes - illustrated by an allele of IGHV3-7
Sequencing of immunoglobulin germline gene loci is a challenging process, e.g. due to their repetitiveness and complexity, hence limiting the insight in the germline gene repertoire of humans and other species. Through next generation sequencing technology, it is possible to generate immunoglobulin transcript data sets large enough to computationally infer the germline genes from which the transcr
The S-wave angle identifies arrhythmogenic right ventricular cardiomyopathy in patients with electrocardiographically concealed disease phenotype
Background: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) carries risk of sudden death. We hypothesize that the S-wave angle differentiates ARVD/C with otherwise normal electrocardiograms from controls. Materials and methods: All patients met Task Force 2010 definite ARVD/C criteria. ARVD/C patients without Task Force depolarization/repolarization criteria (−ECG) were compared
Incorporating regulatory guideline values in analysis of epidemiology data
Fundamental to regulatory guidelines is to identify chemicals that are implicated with adverse human health effects and inform public health risk assessors about “acceptable ranges” of such environmental exposures (e.g., from consumer products and pesticides). The process is made more difficult when accounting for complex human exposures to multiple environmental chemicals. Herein we propose a new
Mass spectrometry evaluation of a neuroblastoma SH-SY5Y cell culture protocol
Cell line-based proteomics studies are susceptible to intrinsic biological variation that contributes to increasing false positive claims; most of the methods that follow these changes offer a limited understanding of the biological system. We applied a quantitative proteomic strategy (iTRAQ) to detect intrinsic protein variation across SH-SY5Y cell culture replicates. More than 95% of the quantif