The role of airway clearance in inhaled drug therapy is complex. Disease-induced bronchoconstriction results in a central drug-deposition pattern where mucociliary clearance is most efficient. When drug-induced bronchodilation is achieved, deposition and uptake becomes more peripheral, and because there is less mucociliary clearance in the periphery, this will lead to an unintentional increase in

A strategically minded CFO will realize that strategic corporate risk management is about finding the right balance between risk prevention and proactive value generation. Efficient risk and performance management requires adequate assessment of risk and risk exposures on the one hand and performance on the other. Properly designed, a risk measure should provide information on to what extend the f

Galectins are involved in many cellular processes due to their ability to bind carbohydrates. Understanding their functions has shown the necessity for potent and specific galectin inhibitors. Human galectin-7 (hGal-7), in particular, has been highlighted as an important marker in many types of cancer by either inhibiting or promoting tumour growth. Producing ligands able to selectively targe

Wireless Mesh Networks (WMNs) have the potentialities to greatly penetrate the marketplace in the next decade. They can be considered a hybrid between wireless infrastructure and ad-hoc networks; no other network infrastructure is needed other than the mesh points, thus providing flexibility in building and expanding the network, allowing for automatic discovery of neighboring nodes, increased rel

This paper is built upon recognizing the need that digital forensic investigators are required in many cases to investigate, understand and report on all kind of cyber-crime including novel security breaches which have not been performed in the past. When an investigator is faced with the challenge to explore a new threat, we argue that the inquiry dynamics do not differ from an organisational emp

This paper presents a framework and a tool to assess transport sustainability in Swedish cities that was developed for and together with some cities in Sweden in strong cooperation with the researchers. The tool, called the Transport Sustainability Barometer (TSB), includes a set of hierarchical indicators to measure sustainability in respect to Efficiency, Accessibility, Safety, Liveability, Emis

Popular Abstract in Swedish Sjukskrivning, huvudsakligen relaterad till muskuloskelettala besvär, har ökat i Sverige, framförallt bland kvinnor. Prevalensen besvär i nacke, skuldra och rygg är högre för sjukvårdsbiträden/undersköterskor i jämförelse med anställda inom andra yrken. Det övergripande syftet med föreliggande avhandling var att få ökade kunskaper om mätmetoder, riskfaktorer för framtidThe overall aim of this thesis was to gain further knowledge of the assessments, predictors of future sick leave and intervention with regard to early prevention of neck, shoulder and back disorders in nursing aides/assistant nurses working in the home-care service. In Paper I, 15 clinical tests on impairment level related to the low back, were examined for intra- and inter-rater reliability on 1

We present quantum chemical estimates of ligand-binding affinities performed, for the first time, at a level of theory for which there is a hope that dispersion and polarization effects are properly accounted for (MP2/cc-pVTZ) and at the same time effects of solvation, entropy, and sampling are included. We have studied the binding of seven biotin analogues to the avidin tetramer. The calculations