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Since 2010,there has been enormous social and political hype around artificial intelligence (‘AI’) and how it has, and will, continue to impact society. This is not just puffery, and there is growing recognition across a range of fields that there is an urgent need to further explore the use, scope and impact of AI in relation to digital forms of citizenship and the datafication of societies. Conc

Objective: To investigate the association of different aspects of cognitive impairment, depression and anxiety with walking difficulties in daily life in persons with mild PD.Background: Walking difficulties in daily life are common among persons with Parkinson’s disease (PD) and may cause falls and near falls, limitations in activity, restrictions in participation and decrease in quality of life.

Objective: To investigate whether tandem gait test (TG) can predict future falls and/or near falls in people with Parkinson’s disease (PD). Background: People with PD have balance problems and an increased risk for falls. Although TG has been considered a predictor of falls, no PD-study has controlled results for demographic and disease-specific characteristics or included near falls when investig

ObjectivesSexual satisfaction is a crucial part of sexual health and is positively related to well-being and quality of life. However, there are at present no composite measures of sexual satisfaction available in Swedish. The New Sexual Satisfaction Scale – Short form (NSSS-S) is a measure of sexual satisfaction that has been validated in multiple languages, and the aim of the present study is toObjectivesSexual satisfaction is a crucial part of sexual health and is positively related to well-being and quality of life. However, there are at present no composite measures of sexual satisfaction available in Swedish. The New Sexual Satisfaction Scale – Short form (NSSS-S) is a measure of sexual satisfaction that has been validated in multiple languages, and the aim of the present study is to

Although high-level evidence is currently lacking, noninferiority randomised controlled trials in predefined risk groups in non-muscle-invasive bladder cancer are under way to scientifically prove the safety of urinary biomarker-guided follow-up. To facilitate recommendations for clinical use, it is essential to comply with the EU certification for in vitro diagnostics and to demonstrate cost effe

The study aimed to investigate if primary health care centers (PHCCs) offering nurse-managed hypertensive care differ from PHCCs with other types of hypertension care regarding blood pressure levels and other key indicators. In this cross-sectional study of the hypertension care given in PHCCs in Stockholm County (now called Region Stockholm), we included all 227 PHCCs in the region. To assess the

Cheaper and more sustainable batteries are key to decarbonize the global energy system, and sodium-ion batteries that use far fewer critical materials are an important option. Research now shows that rapidly improving techno-economics of sodium-ion batteries could soon make them competitive with lithium-ion phosphate batteries under a range of scenarios.

In the Comment by Goletti et al. [Phys. Rev. B 111, 117301 (2025)10.1103/PhysRevB.111.117301], concerns are raised regarding the interpretation of our experimental findings, as well as the application of basic ground-state density functional theory (DFT) models pertaining to the C(111)-(2×1) surface presented in our earlier publication [Reed et al., Phys. Rev. B 105, 205304 (2022)2469-995010.1103/

Aims: The high mortality in untreated acute type A aortic dissection (ATAAD) stresses the need for prompt diagnosis and immediate surgical treatment. Our aim was to evaluate the frequency and clinical impact of misdiagnosis and delayed diagnosis of ATAAD. Methods and results: This was a single-centre, retrospective, observational study including all ATAAD patients with available admission charts b

α-Synuclein is a synaptic protein that accumulates primarily in synucleinopathies and secondarily in certain lysosomal storage disorders. However, its physiological roles in health and disease are not fully understood. In part, this has been hampered by the inability to visualize α-synuclein and its cellular localization, due to the lack of specific antibodies and faithful reporters. Here, we used

Glial fibrillary acidic protein (GFAP) is a type-3 intermediate filament protein mainly expressed in astrocytes in the central nervous system. Mutations in GFAP cause Alexander disease (AxD), a rare and fatal neurological disorder. How exactly mutant GFAP eventually leads to white and gray matter deterioration in AxD remains unknown. GFAP is known to be expressed also in neural precursor cells in

Approaches to differentiating pluripotent stem cells (PSCs) into neurons currently face two major challenges-(i) generated cells are immature, with limited functional properties; and (ii) cultures exhibit heterogeneous neuronal subtypes and maturation stages. Using lineage-determining transcription factors, we previously developed a single-step method to generate glutamatergic neurons from human P

We and others have shown that embryonic and neonatal fibroblasts can be directly converted into induced neuronal (iN) cells with mature functional properties. Reprogramming of fibroblasts from adult and aged mice, however, has not yet been explored in detail. The ability to generate fully functional iN cells from aged organisms will be particularly important for in vitro modeling of diseases of ol

We recently showed that defined sets of transcription factors are sufficient to convert mouse and human fibroblasts directly into cells resembling functional neurons, referred to as "induced neuronal"(iN) cells. For some applications however, it would be desirable to convert fibroblasts into proliferative neural precursor cells (NPCs) instead of neurons. We hypothesized that NPC-like cells may be

Available methods for differentiating human embryonic stem cells (ESCs) and induced pluripotent cells (iPSCs) into neurons are often cumbersome, slow, and variable. Alternatively, human fibroblasts can be directly converted into induced neuronal (iN) cells. However, with present techniques conversion is inefficient, synapse formation is limited, and only small amounts of neurons can be generated.