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Microcontact imprinting based surface plasmon resonance (SPR) biosensor for real-time and ultrasensitive detection of prostate specific antigen (PSA) from clinical samples

Prostate specific antigen (PSA) is an important biomarker for diagnosis and prognosis of prostate cancer. Herein, microcontact PSA-imprinted surface plasmon resonance (SPR) sensor chip was developed for sensitive, real-time detection of PSA. The imprinted chip was prepared in the presence of methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker via

Bone marrow ectopic expression of a non-coding RNA in childhood T-cell acute lymphoblastic leukemia with a novel t(2;11)(q11.2;p15.1) translocation

Chromosomal translocations play a crucial role in tumorigenesis, often resulting in the formation of chimeric genes or in gene deregulation through position effects. T-cell acute lymphoblastic leukemia (T-ALL) is associated with a large number of such rearrangements. We report the ectopic expression of the 3' portion of EST DA926692 in the bone marrow of a childhood T-ALL case showing a t(2;11)(q1

A very intense neutrino super beam experiment for leptonic CP violation discovery based on the European spallation source linac

Very intense neutrino beams and large neutrino detectors will be needed in order to enable the discovery of CP violation in the leptonic sector. We propose to use the proton linac of the European Spoliation Source currently under construction in Lund, Sweden, to deliver, in parallel with the spoliation neutron production, a very intense, cost effective and high performance neutrino beam. The basel

Bodily Mimesis and the Transition to Speech

The chapter reviews evidence for the bodily mimesis hypothesis, which states that the evolution of language was preceded by an adaptation for improved volitional control of the body, giving our ancestors advantages in the domains of imitation, empathy, and gestural communication. Much of this evidence is also shared by other gesture-first theories of language origins, but they face the problem of

Double Affinity Amplification of Galectin-Ligand Interactions through Arginine-Arene Interactions: Synthetic, Thermodynamic, and Computational Studies with Aromatic Diamido-Thiodigalactosides.

A series of aromatic mono- or diamido-thiodigalactoside derivatives were synthesized and studied as ligands for galectin-1, -3, -7, -8N terminal domain, and -9N terminal domain. The affinity determination in vitro with competitive fluorescence-polarization experiments and thermodynamic analysis by isothermal microcalorimetry provided a coherent picture of structural requirements for arginine-arene

Cross-sectional associations between occupational factors and musculoskeletal pain in women teachers, nurses and sonographers.

It is usually assumed that musculoskeletal pain is associated with both the physical workload and the psychosocial work environment, as well as with personal and lifestyle factors. This study aims to ascertain the prevalence of musculoskeletal pain in women with varying or different occupational exposures, and to explore the associations between musculoskeletal pain and the occupational and person

Band functions in the presence of magnetic steps

We complete the analysis of the band functions for two-dimensional magnetic Schrodinger operators with piecewise constant magnetic fields. The discontinuity of the magnetic field can create edge currents that flow along the discontinuity, which have been described by physicists. Properties of these edge currents are directly related to the behavior of the band functions. The effective potential of

A NEMO potential that includes the dipole-quadrupole and quadrupole-quadrupole polarizability.

To increase the accuracy of molecular force fields a systematical and balanced improvement of the various terms included is needed. In this work, we have followed this strategy to improve the quality of the NEMO potential for the formaldehyde dimer by introducing local quadrupole moments and higher-order polarizabilities. It is found that inclusion of the quadrupole moment significantly improves t

Atomic data and theoretical X-ray spectra of Ge-like through V-like W ions

The atomic structure and spectra of ten tungsten ions have been calculated using the Flexible Atomic Code. The calculations yield energy levels, radiative lifetimes, spectral line positions, transition probability rates, and oscillator strengths for the tungsten ions isoelectronic to germanium, W42+, through vanadium, W51+. Collisional-radiative models for high-temperature, low-density plasmas hav

Sexual Health as a Part of Physiotherapy: The Voices of Physiotherapy Students

The aim of the project was to explore and describe the views of physiotherapy students concerning sexual health as a part of physiotherapy education, and to enable them in their future profession as physiotherapists to be able to discuss sexual health matters with patients in an informed, sensitive and relaxed way. A qualitative interview study with data collection through focus group interviews w

Supporting Early Math : Rationales and Requirements for High Quality Software

There is substantial evidence that preschooler’s performance in early math is highly correlated to math performance throughout school as well as academic skills in general. One way to help children attain early math skills is by using targeted educational software and the paper discusses potential gains of using such software to support early math development. Furthermore it is argued that the con

Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: The European Male Aging Study

CONTEXT The cause of declining testosterone (T) in aging men and their relationships with risk factors are unclear. OBJECTIVE To investigate the relationships between lifestyle and health with reproductive hormones in aging men. DESIGN Baseline cross-sectional survey on 3200 community - dwelling men aged 40 - 79 yr from a prospective cohort study in 8 European countries. RESULTS Four predictors we