Immunoglobulins or antibodies are the main effector molecules of the B-cell lineage and are encoded by hundreds of variable (V), diversity (D), and joining (J) germline genes, which recombine to generate enormous IG diversity. Recently, high-throughput adaptive immune receptor repertoire sequencing (AIRR-seq) of recombined V-(D)-J genes has offered unprecedented insights into the dynamics of IG re

Objective: To assess the safety and efficacy of rituximab in systemic sclerosis (SSc) in clinical practice. Methods: We performed a prospective study including patients with SSc from the European Scleroderma Trials and Research (EUSTAR) network treated with rituximab and matched with untreated patients with SSc. The main outcomes measures were adverse events, skin fibrosis improvement, lung fibros

The end-Permian mass extinction, ∼252 million years ago, is notable for a complex recovery period of ∼5 Myr. Widespread euxinic (anoxic and sulfidic) oceanic conditions have been proposed as both extinction mechanism and explanation for the protracted recovery period, yet the vertical distribution of anoxia in the water column and its temporal dynamics through this time period are poorly constrain

Ocean acidification triggered by Siberian Trap volcanism was a possible kill mechanism for the Permo-Triassic Boundary mass extinction, but direct evidence for an acidification event is lacking. We present a high-resolution seawater pH record across this interval, using boron isotope data combined with a quantitative modeling approach. In the latest Permian, increased ocean alkalinity primed the E

Carbohydrates are involved in many cellular processes, and most biomolecules are glycosylated. Thesemodifications are used in biological systems as information carriers, helping regulate organization on the cell surfaceand interactions between cells and the environment. Galectins are a family of carbohydrate binding proteins thatbind to polysaccharides containing a galactose. Galectins have the abCarbohydrates are involved in many cellular processes, and most biomolecules are glycosylated. Thesemodifications are used in biological systems as information carriers, helping regulate organization on the cell surfaceand interactions between cells and the environment. Galectins are a family of carbohydrate binding proteins thatbind to polysaccharides containing a galactose. Galectins have the ab

The BK parameter is discussed in the general context of calculating beyond the factorization approximation for hadronic matrix elements. A variant of the 1 Nc method of Bardeen et al. is used. We present calculations within a low energy approach and a calculation within the Nambu-Jona-Lasinio model. Matching with the QCD behaviour and dependence on non-zero current quark masses is studied.

Syftet med artikeln är att introducera och demonstrera ett pedagogiskt verktyg baserat på användningen av fiktiva fall (vinjetter) konstruerade enligt den experimentella faktoriella surveymetodens principer. Dessa vinjetter är – till skillnad från traditionella ”case” eller ”fallbeskrivningar” – helt igenom kvantitativa, i betydelsen att de kan analyseras i termer av ett antal variabler (dimension

We investigate the single-file dynamics of a tagged particle in a system consisting of N hardcore interacting particles (the particles cannot pass each other) which are diffusing in a one-dimensional system where the particles have different diffusion constants. For the two-particle case an exact result for the conditional probability density function (PDF) is obtained for arbitrary initial partic

Studies have suggested a causal link between behaviors and attitudes prescribed by religious doctrine and child health. However, religious affiliation can also be a marker of differential access to resources and living standards. Studies have found that children born to Muslims in West Africa have poorer health outcomes than children born to Christians. Despite coexisting within national borders,

Background: Repetitive work, work performed in awkward and constrained postures and work with excessive or sustained muscular load is common in many occupational settings. Such work is known to be risk factors for developing musculoskeletal disorders in the neck/shoulder region and in arms and hands. One method that can be used to assess the exposure to these risk factors is technical recordings t

Antimicrobial drug resistance (AMR) in pneumococci complicates the treatment of serious pneumococcal infections. Country-specific AMR patterns can help to establish guidelines for empiric therapy. The aim of the current study was to analyze the distribution of AMR among Streptococcus pneumoniae isolates at Jordan University Hospital (JUH) during 2000–2018. Paper-based and electronic clinical data