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Coordination-Mix: The Hidden Face of STI Policy

This paper sheds light on the policy coordination concept and explores its implications for science, technology, and innovation (STI) policies at the regional level. In particular it analyzes whether systemic and complex STI policies entail a larger and more complex need for coordination. We contribute to the literature by developing a conceptual framework that brings together insights from instit

Leaf area index is the principal scaling parameter for both gross photosynthesis and ecosystem respiration of Northern deciduous and coniferous forests

Data on net CO2 exchange from eight forests in Denmark, Sweden, Finland and Iceland were used to analyse which factors were controlling photosynthesis and respiration. The forests consisted of different species ranging in climatic condition from temperate to subarctic. Only well mixed conditions were analysed (u* > 0.3 m s(-1)). The parameters of a light response function showed strong seasonal va

Ecological Implications of Changes in the Arctic Cryosphere

Snow, water, ice, and permafrost are showing evidence of substantial change in the Arctic, with large variations among different geographical areas. As a result of these changes, some habitats and their associated ecosystems are expanding, while others are undergoing rapid contraction. The warming of the Arctic cryosphere is limiting the range for cold-adapted biota, and less specialized taxa incl

Bioavailability of DOC in leachates, soil matrix solutions and soil water extracts from beech forest floors

The biodegradability of dissolved organic carbon (DOC) in different fractions from the forest floor was studied. Soil leachate (SI, the soil solution in macropores which is freely drained from forest floor after rainfall), the soil matrix solution (SMS, the soil solution in meso-/micropores of the soil matrix), and soil water extracts (SWE) from two different beech forest floors were compared. Zer

Retinoic Acid Is Involved in the Metamorphosis of the Anal Fin into an Intromittent Organ, the Gonopodium, in the Green Swordtail (Xiphophorus hellerii).

In poeciliid fish the male anal fin has been transformed into a gonopodium, an intromittent organ required for internal fertilization. Elevated testosterone levels induce metamorphosis of a subset of anal fin rays to grow and form the specialized terminal structures of the gonopodium. The molecular mechanisms underlying these processes are largely unknown. Here, we investigated whether retinoic ac

Hypothalamic overexpression of mutant huntingtin causes dysregulation of brown adipose tissue.

Expression of mutant huntingtin (htt) protein has been shown to cause metabolic imbalance in animal models of Huntington disease (HD). The pathways involved are not fully understood but dysfunction of both the hypothalamus and brown adipose tissue (BAT) has been implicated. Here we show that targeted expression of mutant HTT in the hypothalamus leads to loss of the A13 dopaminergic cell group loca

Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice

Systemic instigation is a process by which endocrine signals sent from certain tumors (instigators) stimulate BM cells (BMCs), which are mobilized into the circulation and subsequently foster the growth of otherwise indolent carcinoma cells (responders) residing at distant anatomical sites. The identity of the BMCs and their specific contribution or contributions to responder tumor growth have bee

Does the Dynamic Stokes Shift Report on Slow Protein Hydration Dynamics?

The time-dependent fluorescence frequency shift of protein-attached probes has a much slower decay than that for the free probe. The decay times, ranging from 10 ps to several nanoseconds, have been attributed to hydration water motions several orders of magnitude slower than those in the hydration shell of small solutes. This interpretation deviates strongly from the prevailing picture of protein

Men's experiences of giving and taking social support after their wife's spinal cord injury

The aim of this study was to gain an understanding of how men living with women with spinal cord injury (SCI) experienced and acted when they were giving and taking social support to and from their wives and other persons in their social network. Another aim was to give some possible explanations of the complex process of change that they went through. Data were collected through in-depth intervie

STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME): An extension of the STROBE statement

Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological change, susceptibility and clinical outcomes are used as proxies for investigating interactions between external and / or endogenous agents and body components or processes. The need for improved reporting of scientific research led to influ

Diagnostic Methods

Non-invasive vascular studies can provide crucial information on the presence, location, and severity of critical limb ischaemia (CLI), as well as the initial assessment or treatment planning. Ankle-brachial index with Doppler ultrasound, despite limitations in diabetic and end-stage renal failure patients, is the first-line evaluation of CLI. In this group of patients, toe-brachial index measurem

Microvariation in Norwegian long distance binding

It is well known that (some speakers of) Norwegian allow long distance binding, defined here as binding across a finite clause boundary. A number of factors that facilitate long distance binding have also been identified. In the study reported on here, 93 native speakers of Norwegian judged 30 sentences in a web-based questionnaire. The results show that V2 order in the embedded clause reduces the

Fiber plant manager: an OTDR- and OTM-based PON monitoring system

Wider deployment of fiber in the last mile is driven by increased customer needs for high capacity communication. This deployment requires solutions that reduce the operators' OPEX. A cost-efficient fully reliable and accurate monitoring solution supporting fault detection, identification, and localization in different fiber access topologies will be a key part of such solutions. In this article,

Longitudinal relationships between fluid status, inflammation, urine volume and plasma metabolites of icodextrin in patients randomized to glucose or icodextrin for the long exchange

Background. Randomized trials have shown that icodextrin reduces the volume of extra-cellular fluid (ECFv) with variable effects on residual renal function. To explore this fluid shift and its possible mechanisms in more detail, prospectively collected data from one such trial, including measures of inflammation (C-reactive protein, tumor necrosis factor-a, albumin and low and high molecular weigh

EPR systems and new business models. Reuse and recycling of textiles in the Nordic region

This report is the outcome of Part I of a research project entitled An EPR system and new business models to in- crease reuse and recycling of textiles in the Nordic region. The overall aim of the project is to propose policy packages in Nordic countries which would support extended producer responsibility (EPR) systems and innovative business models which promote greater reuse and recycling of us

In Search of Word Accents in Estonian Swedish

This study focuses on the word accent opposition in a lesser known and endangered variety of Swedish–Estonian Swedish. The variety has been described as not making the tonal distinction between Accent 1 and Accent 2 words, but no systematic acoustic phonetic investigation has been carried out previously to confirm these descriptions. As materials, disyllabic words from read sentences, spontaneous