Popular Abstract in Swedish Diffust storcelligt B-celllymfom (DLBCL) är den vanligaste aggressiva lymfomsjukdomen, och drabbar ca 450 personer årligen i Sverige. Med modern antracyklin-innehållande cytostatikabehandling är DLBCL en potentiellt botbar sjukdom. Av patienter med lokaliserad sjukdom botas 70 %, med spridd sjukdom ca 50 %. Bakgrunden till arbete 1 i denna avhandling var en rapport därDiffuse large B-cell lymphoma (DLBCL) is the most frequent lymphoma subtype. In Sweden 450 new cases are diagnosed annually. With modern anthracycline-containing chemotherapy DLBCL is potentially curable, with an estimated overall cure rate of approximately 50% for patients with advanced stage disease. Through molecular profiling of DLBCL the ?cell-of-origin concept? has been established: patients

Hosts can in principle employ two different strategies to defend themselves against parasites: resistance and tolerance. Animals typically exhibit considerable genetic variation for resistance (the ability to limit parasite burden). However, little is known about whether animals can evolve tolerance (the ability to limit the damage caused by a given parasite burden). Using rodent malaria in labora

In order to evaluate the success of simple heuristics we need to know more about how a relevant heuristic is chosen and how we learn which cues are relevant. These meta-abilities, we believe, are at the core of ecological rationality, rather than the individual heuristics.

A dynamic beam system loaded harmonically in the axial direction and constrained in the transverse direction is modelled using different theoretical descriptions. Results from an experimental set-up are compared to calculations using Bernoulli as well as Timoshenko beam theories. Some results from investigations of this beam system unveiling its chaotic nature have earlier been presented, but here

Popular Abstract in Swedish Istället för fred gav det kalla krigets slut upphov till nya säkerhetspolitiska utmaningar i form av inomstatliga konflikter. Under perioden 1989-2000 utkämpades 111 väpnade konflikter runt om i världen varav de flesta kan karakteriseras som inomstatliga, såsom inbördeskriget i Somalia, det våldsamma sammanbrottet i Jugoslavien, och folkmordet i Rwanda. Trots att både hThis study is concerned with tracing the process of how conflict prevention is moving from the realm of ideas to the field of action. Why is it that, despite historical as well as recent evidence of the infeasibility to prevent wars, the idea of conflict prevention has resurfaced to meet the challenge of the new wars of the post-Cold War era? The study investigates whether the growing interest in

Using a variational approach we prove an optimal nonlinear convolution inequality. This result is then applied to give criteria for finite-time blow-up of solutions to a nonlinear model equation in elasticity, improving considerably upon recent blow-up results.

Mesoporous thin films of cerium dioxide were prepared by using a copolymer surfactant (Pluronics 123) at ambient conditions in alcohol as a solvent. The material was produced via a direct calcination step, without the necessity of a gelling stage. The synthesised CeO2 matrix was crystalline with a high surface area. The solution height over the synthesis vessel before the calcination step was foun

BACKGROUND: Bile tolerant helicobacter species such as H hepaticus and H bilis have frequently been reported to cause hepatitis in mice and other rodents. AIMS: To investigate the possible pathogenic role of these and other helicobacter species in chronic liver disease in humans. METHODS: Serum samples from 144 patients with various chronic liver diseases, 30 patients with primary sclerosing chola

The aim of the Swedish educational policy is educational participation and academic achieivement for all children, irrespective of ethnic background. Majority language instruction is an important tool used to achieve this goal. We argue that taking lessons in Swedish-as-a-second-language (S2) sets children apart in their class and limits their possibilities to interact with Swedish children and th

Background: Laser photocoagulation is a well-established treatment for diabetic retinopathy but the mechanism behind its effectiveness has not been elucidated. The protein kinase C (PKC) family is a group of enzymes which has been the subject of extensive interest in clinically related research since the advent of its role in the pathogenesis of diabetic retinopathy. With this study we wanted to e

During 1980-82, 739 ankle fractures occurred in Malmo. These were compared with 383 ankle fractures occurring in 1950-52. In men there was an increase in the age-specific incidence up to the age of 60, especially in fractures of the lateral malleolus. In women there was an increase in the age-specific incidence above the age of 50, both in lateral malleolar fractures and, even more pronounced, in

To model the structural and functional parts of the water oxidizing complex in Photosystem II, a dimeric manganese(II,II) complex (1) was linked to a ruthenium(II)tris-bipyridine (Ru(II)(bpy)(3)) complex via a substituted L-tyrosine, to form the trinuclear complex 2 [J. Inorg. Biochem. 78 (2000) 15]. Flash photolysis of 1 and Ru(II)(bpy)(3) in aqueous solution, in the presence of an electron accep

We use Stein's method in combination with notions from graph theory to obtain Berry-Esseen and central limit theorems for generalized serial rank statistics.

Force-velocity relations, rate of ATP turnover (JATP), and phosphorylation of the 20,000 D myosin light chains (LC20) were measured in chemically skinned guinea pig Taenia coli. Relative LC20 phosphorylation at 3.2 mM MgATP was 17% in relaxed tissues at pCa 9, and increased with force at increasing [Ca2+] to a maximum of 67% at pCa 4.5. Force at pCa 4.5 was dependent on the MgATP concentration wit

The max-bisection problem is to find a partition of the vertices of a graph into two equal size subsets that maximizes the number of edges with endpoints in both subsets. We obtain new improved approximation ratios for the max-bisection problem on the low degree k-regular graphs for 3 less than or equal to k less than or equal to 8, by deriving some improved transformations from a maximum cut into