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Numerical and experimental study of the roughness effects on mechanical properties of AISI316L by nanoindentation

Surface roughness is a commonly used criterion for characterization of surface quality in a ma-chining operation. In the study of micro-scale mechanical properties of machined surface and cut-ting tool using nanoindentation method, perfect surface finish on the specimen is often required for the reliable indentation result. However, the perfect surface finish is often difficult to obtain from the

Impact of wind turbine sound on annoyance, self-reported sleep disturbance and psychological distress

Purpose of the research: The present government in the Netherlands intends to realize a substantial growth of wind energy before 2020, both onshore and offshore. Wind turbines, when positioned in the neighborhood of residents may cause visual annoyance and noise annoyance. Studies on other environmental sound sources, such as railway, road traffic, industry and aircraft noise show that (long-term)

Short-circuit analysis of a doubly fed induction generator wind turbine with direct current chopper?protection

Modern doubly fed induction generator (DFIG) wind turbines can ride through a symmetrical fault in the network by using a chopper protection on the direct current (DC) link without triggering a crowbar protection. A novel method to model the DC link system of such wind turbines as an equivalent resistance during symmetrical faults is presented in this paper. The method allows looking at the DFIG w

An Undercooled Scree Slope Detected by Geophysical Investigations in Sporadic Permafrost below 1000 M ASL, Central Austria

Multi-method geophysical investigations, accompanied by microclimatic measurements and vegetation mapping, were performed at an undercooled scree slope near Schladming (Austria) in the eastern Alps in order to detect, map and monitor mountain permafrost. The study site, at an elevation of 990m asl, is one of the lowest-lying examples of a cold, undercooled scree slope in the Alps. Geophysical meas

Primary hippocampal neurons, which lack four crucial extracellular matrix molecules, display abnormalities of synaptic structure and function and severe deficits in perineuronal net formation.

The extracellular matrix (ECM) of the brain plays crucial roles during the development, maturation, and regeneration of the CNS. In a subpopulation of neurons, the ECM condenses to superstructures called perineuronal nets (PNNs) that surround synapses. Camillo Golgi described PNNs a century ago, yet their biological functions remain elusive. Here, we studied a mouse mutant that lacks four ECM comp

Bonding Trends in Molecular Compounds of Lanthanides: The Double-Bonded Carbene Cations LnCH(2) (+) (Ln=Sc, Y, La-Lu).

Quasi-relativistic Douglas-Kroll CASPT2 calculations are reported for the title molecules, mainly to provide primary data for a fit of double-bond covalent radii. Indeed, a well-developed sigma(2)pi(2) double bond is identified in all cases. For Eu and Yb, however, it is an excited state. The main valence orbitals of all Ln ions are 6s and 5d. In the sigma bonds, more 5d than 6s character is found

Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK, p38MAPK, and NF-kappa B in macrophages

Lycopene has antioxidant, anticancer, and anti-inflammatory effects with molecular mechanisms not fully identified. We investigated the effects of lycopene on the inflammatory responses to lipopolysaccharide (LPS) in RAW264.7 cells and the signal transduction pathways involved. Lycopene inhibited LPS-induced production of nitric oxide (NO) and interleukin-6 (IL-6) with decreased mRNAs of inducible

Adeno-associated viral vector serotypes 1 and 5 targeted to the neonatal rat and pig striatum induce widespread transgene expression in the forebrain

Viral vector-mediated gene transfer has emerged as a powerful means to target transgene expression in the central nervous system. Here we characterized the efficacy of serotypes 1 and 5 recombinant adeno-associated virus (rAAV) vectors encoding green fluorescent protein (GFP) after stereotaxic delivery to the neonatal rat and minipig striatum. The efficiency of GFP expression and the phenotype of

Large-scale candidate gene scan reveals the role of chemoreceptor genes in host plant specialisation and speciation in the pea aphid

Understanding the drivers of speciation is critical to interpreting patterns of biodiversity. The identification of the genetic changes underlying adaptation and reproductive isolation is necessary to link barriers to gene flow to the causal origins of divergence. Here, we present a novel approach to the genetics of speciation, which should complement the commonly used approaches of quantitative t

French-Dutch bilinguals do not maintain obligatory semantic distinctions: Evidence from placement verbs

It is often said that bilinguals are not the sum of two monolinguals but that bilingual systems represent a third pattern. This study explores the exact nature of this pattern. We ask whether there is evidence of a merged system when one language makes an obligatory distinction that the other one does not, namely in the case of placement verbs in French and Dutch, and whether such a merged system

Professional identity on the Web: Engineering blogs and public engagement

Blogs offer a space where engineers can engage with public audiences about engineering topics, challenging and surpassing a deficit model of science communication. Communication that is adapted for a broad audience, discusses topics that are socially relevant, and facilitates participation and dialogue is more likely to be engaging. We examined 14 top engineering blogs to see how engineers present

Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6C(hi) monocyte precursors

Macrophages (m phi) are essential for intestinal homeostasis and the pathology of inflammatory bowel disease (IBD), but it is unclear whether discrete m phi populations carry out these distinct functions or if resident m phi change during inflammation. We show here that most resident m phi in resting mouse colon express very high levels of CX3CR1, are avidly phagocytic and MHCII hi, but are resist

Doctors' and interpreters' conversational styles in paediatric diabetes encounters : A case study of empowering language use

During the last few decades, ideas of empowerment, person-centred care (PCC) and shared decision-making (SDM) have informed western health care. An increasing interest in conversational styles aligned with these ideas is visible e.g. in the work to make motivational interviewing (MI) an evidence-based communicative practice. But linguistic competence is needed to identify the subtle nuances of the

Tractable Algorithms for Robust Model Estimation

What is the computational complexity of geometric model estimation in the presence of noise and outliers? We show that the number of outliers can be minimized in polynomial time with respect to the number of measurements, although exponential in the model dimension. Moreover, for a large class of problems, we prove that the statistically more desirable truncated L2-norm can be optimized with the s

Isokinetic behavior in the gas phase hydrogenation of nitroarenes over Au/TiO2: application of the selective energy transfer model

The gas phase selective hydrogenation of a series of nitroarenes (nitrobenzene, p-chloronitrobenzene, p-bromonitrobenzene, p-nitroaniline, p-nitrotoluene, p-nitrophenol and p-nitroanisole) has been examined over Au/TiO2 (0.3 % w/w Au, mean Au particle size = 3.9 nm). Compensation behavior is demonstrated with an associated isokinetic temperature (T-iso) of 558 +/- 32 K. We account for this respons

Anesthesia Aggravates Lung Damage and Precipitates Hypotension in Endotoxemic Sheep

Beneficial anti-inflammatory properties have been ascribed to volatile anesthetics in septic conditions, but no studies have compared anesthesia to the conscious state in a large-animal model. The aim of this study was to investigate the effect of isoflurane anesthesia on cardiovascular and respiratory function, leukocyte activation, and lung damage in a model of endotoxemia in sheep. Conscious (n