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Six healthy volunteers were exposed to gaseous hexahydrophthalic anhydride (HHPA) concentrations of 10, 40, or 80 micrograms.m-3 (65, 260 or 520 nmol.m-3, respectively) for 8 h. The respiratory uptake of the inhaled HHPA was almost complete. Rapid increases in plasma and urinary levels of hexahydrophthalic acid (HHP acid) were seen. During the first 4 h after the end of exposure, the half-time of

This article addresses the role of proximity for knowledge collaboration between dedicated biotechnology firms (DBFs) and related actors. Innovation projects managed by a selection of eight Swedish DBFs are analysed in detail and classified with regard to their specific knowledge characteristics. Based on this classification, explanations to the relative importance of functional and relational pro

In this study, we assessed the prevalence of self-rated post-traumatic stress in relation to reported trauma in an unselected primary care population. A total of 1113 out of 1378 consecutive attenders (response rate 81%) to 10 health centres completed the self-report instruments Impact of Event Scale (IES), and Post Traumatic Symptom Scale (PTSS-10). A horizontal visual analogue scale (VAS; 0-100

Depending on the balance between sink and source processes for C, drained organic forest soil ecosystems can be in balance or act as net sinks or sources of CO2 to the atmosphere. In order to study the effect of groundwater level and soil temperature on C-flux, the CoupModel was calibrated (climate data, groundwater levels, soil CO2 flux, net ecosystem fluxes of CO2-exchange, sensible heat flux an

We describe a novel cell culture protocol for the generation of neurons from a human teratocarcinoma cell line. These neurons were used to investigate hypoxic-ischaemic cell damage and for developing neuroprotective strategies. Cultures of human model neurons should eventually serve to reduce the number of experimental animals in cerebral stroke research.

The ultrafast decay of the x-ray diffraction intensity following laser excitation of an InSb crystal has been utilized to observe carrier dependent changes in the potential energy surface. For the first time, an abrupt carrier dependent onset for potential energy surface softening and the appearance of accelerated atomic disordering for a very high average carrier density have been observed. Inert

BACKGROUND: Intestinal ischaemia-reperfusion can lead to pulmonary injury characterised by increased macromolecular leakage and leukocyte sequestration. Important mediators of ischaemia-reperfusion-associated injury include polymorphonuclear granulocytes and platelet-activating factor. AIM: To investigate the potential therapeutic inhibition of platelet-activating factor in intestinal ischaemia-re

Tumor-associated trypsin-2 and matrix metalloprotease-9 (MMP-9) are associated with cancer, particularly with invasive squamous cell carcinomas. They require activation for catalytical competence via proteolytic cascades. One cascade is formed by enterokinase, trypsin-2 and MMP-9; enterokinase activates trypsinogen-2 to trypsin-2, which is an efficient proMMP-9 activator. We describe here that ora

The analysis of Helicobacter pylori proteins is a demanding task for the elucidation of virulence factors, antigens and vaccines, all important for diagnosis, therapy and protection. In the "pre-genomic era" the purification of proteins was mostly performed by using various techniques such as detergent treatment of the bacterial cells, ultra-centrifugation, various chromatographic methods, antibod

Investigating claims that a clothed person’s mass loss does not always represent their evaporative heat loss (EVAP), a thermal manikin study was performed measuring heat balance components in more detail than human studies would permit. Using clothing with different levels of vapor permeability and measuring heat losses from skin controlled at 34°C in ambient temperatures of 10, 20, and 34°C with

Vestibular evoked myogenic potentials (VEMP) has been put forward as a test to evaluate the symmetry of saccular function. In the present study, the symmetry of VEMP was evaluated in 23 healthy subjects using automatic analysis. In response to binaural clicks with a stimulus repetition rate of 4/s all subjects revealed significant VEMP on both sides. The ipsilateral response to monaural clicks was

Reconstructing the vortex wake of freely flying birds is challenging, but in the past few years, direct measurements of the wake circulation have become available for a number of species. Streamwise circulation has been measured at different positions along the span of the birds, but no measurements have been performed in the transverse plane. Recent findings from studies of bat wakes have pointed

The acidity and basicity of prereduced V-Ti-O catalysts were measured by adsorption of NH3 and CO2. It was found that a high activity in the ammoxidation of 3-picoline corresponds to a relatively small amount of acidic sites. A catalyst selective in the formation of nicotinonitrile requires high concentrations of both acidic and basic sites. These results are discussed, and can be correlated if th

Three aspects on nanocantilevers are presented in this letter. First, we present the fabrication process of 2 mum long freestanding chromium cantilevers with width 150 nm, and thickness 50 nm. Second, a measurement scheme using an atomic force microscope operating in contact mode was employed to study the mechanical properties along the length of the cantilevers. Third, we have investigated extrem

We show how to find series expansions for pi of the form pi = Sigma(n=0)(infinity) S(n)/((mn)(pn)) a(n), is some polynomial in n (depending on m,p,a). We prove that there exist such expansions for m = 8k, p = 4k, a = (-4)(k), for any k, and give explicit examples for such expansions for small values of m, p and a.

Direct and inverse scattering from dispersive media are studied in the time domain. The media are one-dimensional and homogeneous but can be impedance mismatched to the surrounding media. A time-domain method is introduced where the reflection and transmission kernels are obtained from Volterra equations of the second kind. Numerical examples are given based upon both synthetic and measured data f