Evaluating Basigin promoter variants by CRISPR-Cas9 genome editing
Background: Sequence variation within transcriptional factor binding sites can influence gene expression. We have found a four-nucleotide genetic variant in the Basigin (BSG) promoter region that disrupts a predicted GATA-1 binding site. BSG encodes a red blood cells surface protein on that is exploited as an invasion receptor by the malaria parasite Plasmodium falciparum. Hence the identified var
