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Extensive studies of mice deficient in one or several cytokine receptors have failed to support an indispensable role of cytokines in development of multiple blood cell lineages. Whereas B1 B cells and Igs are sustained at normal levels throughout life of mice deficient in IL-7, IL-7R{alpha}, common cytokine receptor gamma chain, or flt3 ligand (FL), we report here that adult mice double deficient

The single most important factor related to the development of diabetic retinopathy is the duration of diabetes. Little is known about the underlying mechanisms, but many factors have been suggested to be involved, among them derangements in plasma lipids and plasma lipoproteins. In the present study we examined the relation between plasma lipids, plasma lipoproteins, and the duration of diabetes

Atrial electrical and contractile remodeling have been demonstrated to coincide during atrial fibrillation (AF) in experimental studies. We explored whether electrical and contractile remodeling correlate in man and explored its clinical implications. METHODS: Forty-nine patients with persistent AF were studied. Electrical remodeling was assessed noninvasively using spectral analysis to estimate t

The sediment-landform associations of the northern Taymyr Peninsula in Arctic Siberia tell a tale of ice sheets advancing from the Kara Sea shelf and inundating the peninsula, probably three times during the Weichselian. In each case the ice sheet had a margin frozen to its bed and an interior moving over a deforming bed. The North Taymyr ice-marginal zone (NTZ) comprises ice-marginal and supragla

BACKGROUND: During the two recent decades, advocacy has been a topic of much debate in the nursing profession. Although advocacy has embraced a crucial role for nurses, its extent is often limited in practice. While a variety of studies have been generated all over the world, barriers and facilitators in the patient advocacy have not been completely identified. This article presents the findings o

Popular Abstract in Swedish Den huvudsakliga hämmande signalsubstansen i hjärnan är GABA (gamma-aminobutyric acid, gamma-aminosmörsyra). GABA finns i ungefär hälften av alla nervceller i hjärnan och alla nervceller i hjärnan antas ha receptorer som binder GABA. Om man tänker på alla de normala neurologiska funktioner samt rubbningar där GABA är involverat är det inte svårt att förstå GABA:s oerhörInhibitory neurotransmission in the brain is mostly mediated by gamma-aminobutyric acid type A (GABAA) receptors. These receptors are involved in both phasic inhibition (point-to-point inhibition, synaptic transmission) and tonic inhibition (diffuse form of inhibition, brain homeostasis). In this thesis the functional and pharmacological properties of GABAA receptors expressed in brain slices or i

Three sesquiterpenoids that are found in the edible mushrooms Lactarius deliciosus, L. deterrimus and L. sanguifluus, have been assayed for biological activity. The compounds tested were a stearic acid ester of a sesquiterpene (I) and a sesquiterpene aldehyde (lactaroviolin, II) and alcohol (deterrol, III). The assays used were for mutagenic activity in the Ames Salmonella assay, for antimicrobial

Both theoretical and experimental studies of pleural fluid dynamics and lung buoyancy during steady-state, apneic conditions are presented. The theory shows that steady-state, top-to-bottom pleural-liquid flow creates a pressure distribution that opposes lung buoyancy. These two forces may balance, permitting dynamic lung floating, but when they do not, pleural-pleural contact is required. The ani

Aqueous di persions of a porcine lung surfactant (PLS) extract with and without cholesterol supplementation were analyzed by X-ray scattering. Lamellar liquid-crystalline and gel-type bilayer phases are formed, as in pure phosphatidylcholine (PC)-cholesterol systems. This PLS extract, developed for clinical applications, has a cholesterol content of less than 1% (w/w). Above the limit of swelling,

For a class of non-selfadjoint h-pseudodifferential operators in dimension 2, we determine all eigenvalues in an h-independent domain in the complex plane and show that they are given by a Bohr-Sommerfeld quantization condition. No complete integrability is assumed, and as a geometrical step in our proof, we get a KAM-type theorem (without small divisors) in the complex domain.

Popular Abstract in Swedish Denna avhandling presenterar en metod som kan hantera generella tjocka frekvensselektiva strukturer (FSS). Metoden är baserad på modanpassning och finita elementmetoden (FEM). Avhandlingen är en sammanläggningsavhandling och består av en introduktion som följs av fem vetenskapliga artiklar. Frekvensselektiva strukturer fungerar som filter för elektromagnetiska vågor, sThis thesis presents a new method that can handle a general thick Frequency Selective Structure (FSS), that consists of an arbitrary number of aperture layers and dielectric layers. The method is based on the Mode Matching Technique (MMT) and the finite element method (FEM). The thesis consists of a General Introduction and five scientific papers. The General Introduction gives an overview of fil

Summary In 1895 a posthumous essay by the Swedish poet and scholar Viktor Rydberg (1828- 1895) was published with the, for many modern Europeans, provoking title Den hvita rasens framtid (“The future of the white race”). In the late 20th century however “the white race” was a commonly used expression, it did not indicate any right-wing sympathies. Rydberg himself was a leftist, a social liberal. C

The study builds on a previous study of the everyday occupations of 100 women who worked at home and in the paid workforce. Their pattern of daily occupations was depicted using time-occupation graphs inspired by the time geography method, whereby the women’s pattern of occupations were categorised and clustered according to complexity. For each woman, the level of complexity was operationalised a

Surveying Syrian Arabic narrative text, this article explores the use of a switch of verb forms to indicate larger digressions from the main line of a story. The study follows similar analyses of other varieties of Arabic as well as Biblical Hebrew. Isaksson (2007, 2009a) identified specific marking for comments of circumstantial character not only on phrase and clause level but also on text level