A new approach to the constrained function optimization problem is presented. It is shown that the ordinary Lagrange multiplier method and the penalty function method may be generalized and combined, and the new concept ofmultiplier function is introduced. The problem may then be converted into an unconstrained well-conditioned optimization problem. Methods for numerical solution are discussed, an

PURPOSE OF REVIEW: The clinical and inflammatory heterogeneity in asthma constitutes a major challenge for improved treatment. This review describes the nature of the inflammatory complexity and how it can be decoded to yield improved disease understanding and personalized treatment. The focus is on the difficult task of revealing the immunological complexity as it occurs inside diseased patient t

Background: To examine risk of severe perineal trauma among nulliparous women and those undergoing vaginal birth after cesarean delivery (VBAC). Methods: This is a population-based cohort study of all births to women with their two first consecutive singleton pregnancies in Stockholm-Gotland Sweden between 2008 and 2014. Risk of severe perineal trauma was compared between nulliparous women and tho

PURPOSE OF REVIEW: In the past decades, cysteinyl leukotrienes (CysLTs) and prostaglandin D2 have been recognized as key mediators of asthma and comorbid conditions for their potent broncho-active and proinflammatory properties. However, both the development and initial positioning of small molecules targeting these lipid mediators [i.e., leukotriene-synthesis inhibitors, CysLT-antagonists, and ch

Children who have parents with any kind of illness may become young carers who take a responsibility not expected of children for household tasks, or personal or emotional care for parents and siblings. So far, little is known about children in Sweden who are at risk of becoming young carers. The aim of this article is therefore to explore the extent and impact of children's caring activities as r

In aqueous solution of 1,1'-diethyl-2,2'-carbocyanine J-aggregate, the exciton self-trapped (EST) state is usually expected to be negligible. However, in this work, by measuring transient absorption spectroscopy under a variety of excitation fluences, the EST state was found to be formed via coherent exciton-exciton annihilation (EEA), when the excitation fluence was high enough. With the existenc

BackgroundAlthough being married with children is associated with a reduced rate of alcohol use disorder (AUD), is this finding independent of a marital effect, different in mothers and fathers and potentially causal in effect.MethodsUsing Cox proportional hazards, we examined, in 1 252 237 married individuals, the association between a resident younger and older child and risk for AUD registratio

Background: Proteomics is an emerging field in the study of joint disease. Our two aims with this pilot analysis were to compare healthy human knee articular cartilage with meniscus, two tissues both known to become affected in the osteoarthritic disease process, and to compare two mass spectrometry (MS)-based methods: data-dependent acquisition (DDA) and data-independent acquisition (DIA). Method

Universities around the world have increasingly turned to digital infrastructures as a way to revamp the arts and humanities. This article contributes a fresh understanding by examining the material development of HumlabX, a research laboratory for digital humanities at Umea° University, Sweden. Specifically, we approach the empirical case as a timeline of research funding, projects, events, and d

Background: Dementia is a public health priority with a dramatic social and economic impact on people with dementia (PwD), their caregivers and societies. The aim of this study was to contribute to the knowledge on how utilization of formal and informal care varies between Sweden and Italy. Methods: Data were retrieved from two trials: TECH@HOME (Sweden) and UP-TECH (Italy). The sample consisted o

This study focuses on the role of negative-ion formation in the decay of core-valence doubly excited water molecules. Combining negative- and positive-ion coincidence measurements with calculated energies of core-valence doubly excited states, we find that O- and H- production is enhanced selectively. In particular, we suggest that O- production is correlated to double occupancy of the antibonding