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Soft tissue sarcomas (STS) are a heterogeneous group of highly malignant mesenchymal tumors that account for ~1% of all malignancies. Frequent heterogeneity and pleomorphism along with suboptimal diagnostic reproducibility and insufficient prognostic markers make clinical management of these tumors difficult. This thesis has applied microarray-based gene expression and copy-number profiling to STS
Purpose: Autonomous bladder activity can take the form of localized micromotions (MMs), suggesting that the detrusor may be arranged into component modules, of which each is capable of contracting autonomously. We examined MMs in isolated whole rat bladder and the effects of partial bladder outlet obstruction as a model of detrusor overactivity (DO) to ascertain whether altered modular activity co
In an investigation by the Swedish Cancer Society, the present status, critical issues and future aspects and potentials in each of nine major areas of radiation therapy research were described by an expert group. The report presented here deals with radiation therapy dose delivery, dose distributions, beam shaping and intensity modulation.
Calnexin (Cnx) has been characterized as a membrane-bound protein that transiently interacts in a unique chaperone system with newly synthesized glycoproteins in order to allow the establishment of their proper tertiary and, in most cases, quarternary structures. The aim of the study was to identify and to locate the expression of Cnx in the three major salivary glands of humans by different metho
Osteoclastic bone resorption depends on the activity of various proteolytic enzymes, in particular those belonging to the group of cysteme protemases. Biochemical studies have shown that cystatins, naturally occurring inhibitors of these enzymes, inhibit bone matrix degradation. Since the mechanism by which cystatins exert this inhibitory effect is not completely resolved yet, we studied the effec
The undamped natural vibrations of a constrained linear structure are given by the solutions to a generalized eigenvalue problem derived from the equations of motion for the constrained system involving Lagrangian multipliers. The eigenvalue problem derived is defined by the mass matrix of the unconstrained structure and a non-symmetric and singular stiffness matrix for the constrained system. The
The report is a short survey of instrumentation and control in wastewater treatment plants in the USA. Primarily biological and chemical wastewater treatment is considered. The report is based partly on personal experiences from the USA, partly on literature studies.
The healthcare sector constitutes a major part of the economy of developed nations and consumes significant quantities of consumables. The Region Scania commissioned IIIEE, Lund University, to develop a management tool for strategic decision-making in order to reduce the climate impact indirectly derived from material, consumption. The tool was streamlined to fit operational conditions at Region S
The role of endothelium-derived nitric oxide in the regulation of vascular resistance (tonus) in cat skeletal muscle was studied with the use of NG-monomethyl-L-arginine (L-NMMA), a specific inhibitor of nitric oxide formation from L-arginine. The study was performed with a whole-organ technique which permits simultaneous, continuous and quantitative recordings of resistance reactions in the whole
Protein-polymer association in solution driven by a short-range attraction has been investigated using a simple coarse-grain model solved by Monte Carlo simulations. The effect of the spatial distribution of the hydrophobic surface residues of the protein on the adsorption of weakly hydrophobic polymers at variable polymer concentration, polymer length, and polymer stiffness has been considered. S
Popular Abstract in Swedish Astma är en folksjukdom. Uppemot 10 % av befolkningen i Sverige har mer eller mindre uttalade symptom. Barn är ofta värst drabbade. Vid astma drar luftrören ihop sig så att det blir svårt att andas. Detta tillstånd kan vara livshotande. Tack vare lång tids intensiv luftvägsforskning är en del mekanismer i sjukdomsförloppet kartlagda. Till exempel karakteriseras bronksleEosinophils, containing tissue toxic granule proteins, are regarded a culprit cell in asthma pathogenesis. Using animal and human experimental models of asthma effects on eosinophilic airway inflammation were investigated in vivo. The current research paradigm regarding spontaneous and steroid-induced clearance of airway tissue eosinophils exclusively involves death through apoptosis followed by p
The morphological and molecular characterization and of malignant blood disorders is pivotal to ensure a correct diagnosis, guide therapy, and, in the longer term, to identify their molecular causes. Over the past several years, new technology has increased our abilities to describe, typecast, and understand hematologic malignancies beyond what was previously possible. This thesis concerns two suc
Pulsed wave (PW) Doppler ultrasound systems are commonly used to examine blood flow dynamics and the technique plays a very important role in numerous diagnostic applications. Commonly, narrow-band PW systems estimate the blood velocity using an autocorrelation-based estimator. Herein, we examine a recently proposed hybrid frequency estimator, and via extensive numerical simulations using simulate
Findings from a pilot study on the distribution, function and phonetic realization of the filler EH in interviews from SweDia2000 interviews are presented. The results show that EH occurs almost exclusively after function words at the beginning of constituents. The phonetic realization of EH was seen to be of three basic forms: a middle-high vowel (e.g. [e], [ɛ], [ə]), a vowel+nasal (e.g. [ɛm], [ə
Following the recent developments in supply chain management and environmental policy integration, it became evident that for successfully addressing the environmental challenges a holistic approach is necessary. After identifying a lack of sufficient information on the environmental performance and the uptake of the respective policy measures from food supply chain perspective, a research has bee
