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The distribution of tau pathology in Alzheimer's disease (AD) shows remarkable inter-individual heterogeneity, including hemispheric asymmetry. However, the factors driving this asymmetry remain poorly understood. Here we explore whether tau asymmetry is linked to i) reduced inter-hemispheric brain connectivity (potentially restricting tau spread), or ii) asymmetry in amyloid-beta (Aβ) distributio

Solvent cage-escape dynamics of bimolecular photoredox products in solution has been investigated computationally through a combination of molecular dynamics simulations and quantum chemical calculations. The present work focuses on the photoinduced oxidation of the organic electron donor dimethylaniline (DMA) by a Fe(III) N-heterocyclic carbene photosensitizer (Fe(III)NHC+) in two different solve

The Hamming Quasi-Cyclic (HQC) key encapsulation mechanism (KEM), recently selected by NIST for standardization in the Post-Quantum Cryptography (PQC) process, distinguishes itself through its efficiency, robust design based on hard decoding problems in coding theory, and well-characterized decryption failure rates. Despite its selection, practical security concerns arise from implementation threa

This paper presents a search for exotic decays of the Higgs boson into a pair of new pseudoscalar particles, Formula Presented, where one pseudoscalar decays into a Formula Presented-quark pair and the other decays into a Formula Presented-lepton pair, in the mass range Formula Presented. The analysis uses Formula Presented collision data at Formula Presented collected with the ATLAS detector at t

The Urban Heat Island (UHI) effect exacerbates environmental degradation, growing energy demand, and public health risks, especially in densely populated and vulnerable Mediterranean urban communities. This study investigates the spatial heterogeneity of the UHI effect in Barcelona from 2015 to 2023 by integrating multi-source geospatial data and interpretable machine learning techniques. Using Go

The global demand for sustainable, plant-based food systems has increased significantly over the past decade and is projected to continue rising. Andean seeds are interesting contributors, not only for their high nutritional value but also for their ability to grow naturally in very harsh conditions. Among these Andean seeds, four have gained interest due to their nutritional value and potential i

BackgroundChildren with ADHD are reported to have lower dopamine (DA) and norepinephrine (NE) levels compared to typically developing children. We exploratively investigated how blink rate and pupil diameter, which are considered to be proxies for DA and NE signaling, were related to ADHD symptom severity. Moreover, we tested whether this relation is modulated by auditory white noise stimulation,

Background: Neuroimaging with magnetic resonance imaging (MRI) may assist clinicians in evaluating brain injury and optimising care in comatose adults resuscitated after out-of-hospital cardiac arrest (OHCA). However, contemporary international data on its use are lacking. Aim: The primary aim was to compare the patient characteristics, early postresuscitation care, and neurological outcomes of pa

Purpose: This study aims to evaluate the diurnal variations in anterior segment parameters among patients with keratoconus (KC) and to compare these variations across different severity levels of the disease. Methods: A total of 82 patients with KC were included in the study. Corneal parameters were measured at 08:30, 11:30, 14:30, 17:30, and 20:30 using the Pentacam HR (Oculus, Wetzlar, Germany).

When children exercise their right to political participation through climate activism and litigation, they demonstrate that an ethics of care is a core component of the postpaternalist era. Children’s ethics of care, however, is not only about care toward their immediate human relations, but also toward other species, the environment they live in and generations to come. They thereby develop the

The Viking Age (c. 800 – c. 1050 AD) was a period of dramatic change and transformative encounters across Europe and the wider world. Ships, seafarers, and the sea were central to these developments but, paradoxically, the Viking Age is generally studied through evidence and approaches on land. This has consistently hindered scholarly understanding of the maritime dimensions of the Viking Age; sur

Pangenomes are collections of annotated genome sequences of multiple individuals of a species1. The structural variants uncovered by these datasets are a major asset to genetic analysis in crop plants2. Here we report a pangenome of barley comprising long-read sequence assemblies of 76 wild and domesticated genomes and short-read sequence data of 1,315 genotypes. An expanded catalogue of sequence

OBJECTIVES: This is a protocol for a Cochrane Review (prototype). The objectives are as follows: Primary objective To determine the prognostic value of birth weight (BW) and prematurity in predicting the incidence of type 2 diabetes mellitus (T2DM) later in life (among adults, adolescents, and children) compared to normal BW and full-term birth. Secondary objectives To determine the prognostic val

Correlations in azimuthal angle extending over a long range in pseudorapidity between particles, usually called the “ridge” phenomenon, were discovered in heavy-ion collisions, and later found in pp and p–Pb collisions. In large systems, they are thought to arise from the expansion (collective flow) of the produced particles. Extending these measurements over a wider range in pseudorapidity and fi

Background: Kigali, Rwanda’s rapidly growing capital, faces major challenges in household-level Fecal Sludge Management (FSM), with over 89% of households using pit latrines and only 48% accessing unshared sanitation. FSM services are limited, costly, and poorly executed, leading to frequent illegal dumping. Objective: This review analyzes the literature on sanitation in Kigali to identify key gap

Organismal abundance tends to decline with increasing body size. Metabolic theory links this size structure with energy use and productivity, postulating a size–abundance slope of −0.75 that is invariant across environments. We tested the robustness of this relationship across gradients of protist species richness (1–6 species), temperature (15°C–25°C) and time. Using replicated microcosms, we pro

INTRODUCTION: We sought to harmonize genotype data from the predementia AMYPAD (Amyloid Imaging to Prevent Alzheimer's Disease) Consortium, compute polygenic risk scores (PRS), and determine their association with global amyloid deposition. METHODS: Genetic data from five AMYPAD parent cohorts were harmonized, and PRS were computed for Alzheimer's disease (AD) susceptibility, cerebrospinal fluid (

Context. Tidal interactions between massive galaxies and their satellites are fundamental processes in a universe with a λ cold dark matter (λ CDM) cosmology, and they redistribute material into faint features that preserve records of past galactic interactions. While stellar streams in the Local Group impressively demonstrate satellite disruption, they do not constitute a statistically significan

Background and Aims: Perineal wound complications occur frequently after proctectomy in patients with inflammatory bowel disease (IBD), with persistent perineal wounds appearing in some patients. This study examines the surgical outcomes after proctectomy in patients with IBD in a contemporary setting, with primary perineal wound healing as the primary end-point. Methods: This is a multicentre ret