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Objectives: To estimate intra-observer repeatability and inter-observer agreement in 1) describing adnexal masses using the International Ovarian Tumor Analysis (IOTA) terms and definitions, 2) the risk of malignancy calculated using IOTA logistic regression models LR1 and LR2, 3) the diagnosis made on the basis of subjective assessment of ultrasound images. Methods: One hundred and three adne

Despite a lack of randomized trials, practice guidelines recommend that mild induced hypothermia be considered for comatose survivors of in-hospital cardiac arrest. This study describes the safety, feasibility, and outcomes of mild induced hypothermia treatment following in-hospital cardiac arrest.

European CH4 emissions are estimated for the period 2001-2006 using a four-dimensional variational (4DVAR) inverse modeling system, based on the atmospheric zoom model TM5. Continuous observations are used from various European monitoring stations, complemented by European and global flask samples from the NOAA/ESRL network. The available observations mainly provide information on the emissions fr

We present new geochronological evidence of latest Palaeoproterozoic-earliest Mesoproterozoic magmatism in the Telsiai Deformation Zone, NW Lithuania. Employing the laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) at the University of Tasmania, Australia, we demonstrate that a granodiorite, which had previously been considered to belong to the 1850-1820 Ma Kursiai charnockit

Objectives: Acquired trisomy 21 is one of the most common numerical abnormalities in acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), and MDS/MPN; however, little is known about its pathogenic impact, accompanying submicroscopic changes, and its relation to other clinical features. Furthermore, previous studies addressing this issue have mainly focu

The possible interrelations between human leukocyte antigen (HLA)-DQ, non-HLA single-nucleotide polymorphisms (SNPs) and islet autoantibodies were investigated at clinical onset in 1-34-year-old type 1 diabetes (T1D) patients (n=305) and controls (n=203). Among the non-HLA SNPs reported by the Type 1 Diabetes Genetics Consortium, 24% were supported in this Swedish replication set including that th

Do computational models contribute to progress in mechanobiology? Jacobs and Kelly (in Advances on Modelling in Tissue Engineering, p. 1–14, 2011) suggest that they do, but at the same time propose a limitation in the form of the ‘paradox of validation’, whereby the information needed to validate mechanoregulation theories obviates the need for them in the first place. In this article, the corrobo

The balance of intestinal microbiota, which is present in health, can be affected by severe illness and antibiotics. Pathogenic bacteria, which are usually suppressed by the commensal flora, may multiply and can cause complicating secondary infections. Administration of probiotics can help to reduce the deleterious effects of disease and antibiotics in critically ill patients: they can improve gut

A novel inhibitor of zipper-interacting protein kinase (ZIPK) was utilized to examine the involvement of ZIPK in the regulation of smooth muscle contraction. Pre-treatment of de-endothelialized rat caudal arterial smooth muscle strips with the pyrazolo[3,4-d]pyrimidinone inhibitor HS38 decreased the velocity of contraction (time to reach half-maximal force) induced by the phosphatase inhibitor cal

We present a new algorithm for solving the LPN problem. The algorithm has a similar form as some previous methods, but includes a new key step that makes use of approximations of random words to a nearest codeword in a linear code. It outperforms previous methods for many parameter choices. In particular, we can now solve instances suggested for 80-bit security in cryptographic schemes like HB var

The droplet aerosol analyzer (DAA) was developed to study the influence of aerosol properties on clouds. It measures the ambient particle size of individual droplets and interstitial particles, the size of the dry (residual) particles after the evaporation of water vapor and the number concentration of the dry (residual) particles. A method was developed for the evaluation of DAA data to obtain th

We compare the aqueous self-assembly behavior within the homologous peptide series A(n)K, where A is alanine, K is lysine, and n = 4, 6, 8, and 10. The aqueous peptide solubility, phi(s) (volume fraction), depends strongly on the number of hydrophobic alanine residues and decreases approximately as phi(s) approximate to 10(-n). Also the self-assembly structure depends on n. A(4)K is highly water-s

The use of permanent hair dyes exposes hairdressers to contact allergens such as p-phenylenediamine (PPD), and the preventive measures are insufficient.

The effectiveness of psychosocial interventions in community mental healthcare has been shown to depend on the setting in which they are implemented. Recently structured patient-clinician communication was found to be effective in a multi-centre trial in six European countries, the DIALOG trial. In the overall study, differences between centres were controlled for, not studied. Here, we test wheth

Abstract in UndeterminedA longitudinal, micro-level study of the effect of socioeconomic transformations on fertility mechanisms in the rural hinterland of Bologna between 1818 and 1900 (the beginning of the demographic transition) demonstrates that the premature death of a last-born child reduces the interval between two consecutive childbirths. Thus does it confirm the importance of breast-feedi

Objectives: To study the clinical characteristics and epidemiology of the combination of primary systemic vasculitis (PSV) and severe alpha-1 antitrypsin (α1-AT) deficiency. Method: Patients with PSV [granulomatosis with polyangiitis (GPA) (Wegener's), microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (EGPA) (Churg-Strauss), and polyarteritis nodosa] were identified through d

Purpose. The pathogenesis of rhegmatogenous retinal detachment (RRD) remains incompletely understood, with no clinically effective treatment for potentially severe complications such as photoreceptor cell death and proliferative vitreoretinopathy. Here we investigate the protein profile of the vitreous following experimental retinal detachment using a comparative proteomic based approach. Material

We propose to combine the method of fluorescence intensity centroid localization with rotation of the plane of excitation polarization. Polarized light interacts selectively with differently oriented fluorophores; thus yielding topological information on the nanometer scale, without any need for fluorophore blinking. The method is applicable to photostable individual systems, when most of the trad