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Human papillomavirus vaccine efficacy against invasive, HPV-positive cancers : Population-based follow-up of a cluster-randomised trial

Background Human papillomavirus (HPV) vaccination protects against HPV, a necessary risk factor for cervical cancer. We now report results from population-based follow-up of randomised cohorts that vaccination provides HPV-type-specific protection against invasive cancer. Methods Individually and/or cluster randomised cohorts of HPV-vaccinated and non-vaccinated women were enrolled in 2002-2005. H

Analysis of enhanced turbulent heat transfer in a sharp turn channel having novel designed endwall with longitudinal vortex generator

This work provides a new method to enhance endwall heat transfer of a sharp turn channel. Several longitudinal vortex generators (LVGs) at various spacing and aspect ratio are placed in parallel on the inner side of endwall in a sharp turn channel. Liquid crystal thermography, pressure difference measurements, and a statistical method are applied to analyze the thermal behavior, friction factor, a

Prolonged NoGo P3 latency as a possible neurobehavioral correlate of aggressive and antisocial behaviors : A Go/NoGo ERP study

Aggressive and antisocial behaviors are detrimental to society and constitute major challenges in forensic mental health settings, yet the associated neural circuitry remains poorly understood. Here, we investigated differences in aggressive and antisocial behaviors between healthy controls (n = 20) and violent mentally disordered offenders (MDOs; n = 26), and examined associations between aggress

The PanCareFollowUp Care Intervention : A European harmonised approach to person-centred guideline-based survivorship care after childhood, adolescent and young adult cancer

Background: Long-term follow-up (LTFU) care, although endorsed, is not available for the majority of adult survivors of childhood, adolescence and young adult (CAYA) cancer. Barriers to implementation include lack of time, knowledge, personnel and funding. Sustainable solutions are urgently needed to address the needs of CAYA cancer survivors to improve the quality of life and reduce the burden of

MATERNAL OUTCOMES IN NULLIPAROUS WOMEN WHO GAVE VAGINAL BIRTH ON A BIRTH SEAT OR IN ANY OTHER POSITION: RESULTS OF A RANDOMISED CONTROLLED TRIAL IN SWEDEN

Background: Upright birth positions may reduce the risk for instrumental delivery. The aim of this study was to test, by means of a randomised controlled trial, the hypothesis that the use of a birthing seat during the second stage of labour decreases the number of instrumental deliveries and thus counterbalance any adverse perineal outcome or severe blood loss.Methods: One-thousand and two nullip

Ethics of Probabilistic Extreme Event Attribution in Climate Change Science : A Critique

The question whether a single extreme climate event, such as a hurricane or heatwave, can be attributed to human induced climate change has become a vibrant field of research and discussion in recent years. Proponents of the most common approach (probabilistic event attribution) argue for using single event attribution for advancing climate policy, not least in the context of loss and damages, whiThe question whether a single extreme climate event, such as a hurricane or heatwave, can be attributed to human induced climate change has become a vibrant field of research and discussion in recent years. Proponents of the most common approach (probabilistic event attribution) argue for using single event attribution for advancing climate policy, not least in the context of loss and damages, whi

Idac-alpha : An alpha dosimetry software for normal organs and tissues

Radiopharmaceuticals have been used for the treatment of various forms of cancer since the 1940s. In recent years, the advantages of alpha emitting radionuclides have emerged as a favourable treatment option. However, most alpha emitting radionuclides have long decay chains with long-lived daughter radionuclides. This leads to uncertainties in the dosimetry for normal organs and tissues, when esta

How to Take Over and Revise a Medical Ethnology Course in the Post-Everything Era

Nearly all university lectures have faced the challenges of taking over a course from colleagues. Yet the conceptual and practical challenges of this process are rarely discussed in higher education. In this article, I describe my experiences of becoming the course convenor of an existing medical ethnology course and revising it. The first challenge was to make the course my own, while also mainta

The role of water coordination in the pH-dependent gating of hAQP10

Human aquaporin 10 (hAQP10) is an aquaglyceroporin that assists in maintaining glycerol flux in adipocytes during lipolysis at low pH. Hence, a molecular understanding of the pH-sensitive glycerol conductance may open up for drug development in obesity and metabolically related disorders. Control of hAQP10-mediated glycerol flux has been linked to the cytoplasmic end of the channel, where a unique

Is road-side fishpond water in Bangladesh safe for human use? An assessment using water quality indices

Pond water is used in everyday life by many people in Bangladesh, however, without sufficient and reliable information regarding water quality and pollution status. For this reason, geospatial analysis and mapping of water quality indices such as metal (MI), contamination (Cd), and physicochemical water quality index (WQI) were assessed to improve the understanding of potential pollution sources.

1H detection and dynamic nuclear polarization–enhanced NMR of Aβ1-42 fibrils

Several publications describing high-resolution structures of amyloid-β (Aβ) and other fibrils have demonstrated that magic-angle spinning (MAS) NMR spectroscopy is an ideal tool for studying amyloids at atomic resolution. Nonetheless, MAS NMR suffers from low sensitivity, requiring relatively large amounts of samples and extensive signal acquisition periods, which in turn limits the questions tha

Long term oncologic and reproductive outcomes after robot-assisted radical trachelectomy for early-stage cervical cancer. An international multicenter study

Objectives: Long term outcomes following fertility sparing robot-assisted radical trachelectomy (RRT). Methods: A retrospective study of consecutive women selected for RRT between 2007 and 2019 at five referral centres. Generally used selection criteria for fertility-sparing surgery were applied. Oncologic, reproductive and long-term clinical data were analysed. Results: Of the 166 included women,