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A major challenge in the design of electrochemical biodevices is to achieve fast rates of electron exchange between proteins and electrodes. In this work, we show that a significant increase in the direct electron transfer rate between a graphite electrode and Tobacco Peroxidase takes place when a surface exposed leucine, located in the vicinity of the heme pocket, is replaced by tryptophan. The a
In this work an experimental and kinetic modeling study on n-propanol and i-propanol combustion has been performed. New burning velocity measurements were carried out using the heat flux method at 1 atm over the temperature range of 323–393 K. Analysis of the temperature dependence was conducted with to verify the data consistency of the new and available data from the literature. Important incons
This paper presents a numerical model designed to simulate subaqueous cross-shore profile behavior, including response of feeder mounds and barred systems. The present model development builds on the semi-empirical model proposed by Larson et al. (2013), designed to simulate the evolution of longshore bars exposed to incident waves, as well as the exchange of material between the bar and the berm
Roads are subjected to traffic loads and varying climate conditions that eventually lead to different types of damage. Moisture in asphalt is one of the major causes of premature failure in asphalt pavements. In addition, moisture in the unbound layers and temperature in the asphalt concrete (AC) layers affect the structural response of pavements under loading, such as the tensile strain at the boRoads are subjected to traffic loads and varying climate conditions that eventually lead to different types of damage. Moisture in asphalt is one of the major causes of premature failure in asphalt pavements. In addition, moisture in the unbound layers and temperature in the asphalt concrete (AC) layers affect the structural response of pavements under loading, such as the tensile strain at the bo
In order to overcome the shortcomings of crash data a number of surrogate measures of safety have been developed and proposed by various researchers. One of the most widely used temporal indicators is time-to-collision (TTC) which requires the road users to be on a collision course. Road users that are strictly speaking not on a collision course actually might behave and take evasive actions as if
A substantial portion of grassland photosynthates is allocated belowground to arbuscular mycorrhizal fungi (AMF), but controversy remains about whether this carbon (C) contributes to soil organic carbon (SOC) under warming. The goal of this study was to investigate how AMF biomass and C sequestered by AMF (CNew) are influenced by soil warming. We estimated the AMF biomass and CNew, assumed to be m
Atopic dermatitis (AD) is a complex disease with elevated risk of respiratory comorbidities.1,2 Severely affected patients are often treated with immune-modulating systemic drugs.3,4 On March 11th 2020, the World Health Organization declared the 2019 novel coronavirus severe acute respiratory syndrome (SARS-Cov-2) epidemic to be a pandemic. The number of cases worldwide is increasing exponentially
Similarities and differences in the everyday clinical management of moderate-to-severe atopic dermatitis in Nordic countries are unknown. Using a modified Delphi approach, 15 dermatologists from Denmark, Finland, Norway and Sweden completed face-to-face and online questionnaires and participated in summary discussions to map expert opinion on the clinical management of moderate-to-severe atopic de
This is the report from the fifth meeting of the Harmonising Outcome Measures for Eczema initiative (HOME V). The meeting was held on 12–14 June 2017 in Nantes, France, with 81 participants. The main aims of the meeting were (i) to achieve consensus over the definition of the core domain of long-term control and how to measure it and (ii) to prioritize future areas of research for the measurement
Yield levels and the factors determining crop yields is an important strand of research on rainfed family farms. This is particularly true for Sub-Saharan Africa (SSA), which reports some of the lowest crop yields. This also holds for Ghana, where actual yields of maize, the most important staple crop, are currently about only a third of achievable yields. Developing a comprehensive understanding
This study is concerned with the integration of negation in relation to two models of the processing of negation: (i) the two-step model (Lüdtke et al., 2008), according to which negation involves two representations where negation is ignored in the first representation, and (ii) the pragmatic view (Nieuwland & Kuperberg, 2008), which posits that negation can be integrated without delay if it
Walking as a means of transportation is a key feature in sustainable urban design, but few studies have examined the influence of micro-level environmental features, such as vegetation and street lighting, on perceived safety and people’s choice to walk. This study applied a non-explicit approach to examine the relationship between greenery, street lighting, perceived safety, and walking in an urb
Desalination can be a cost-effective way to produce fresh water and possibly electricity. The Gaza Strip has had a complex hydro-political situation for many years. Gaza is bordered by the Mediterranean sea in the west, by Israel in the north and east and by Egypt in the south. Water and electricity consumption in the Gaza Strip is expected to increase in the future due to the increasing in popula
Background: COVID-19 is a rapidly spreading virus infection that has quickly caused extensive burden to individual, families, countries, and the globe. No intervention has yet been proven effective for the treatment of COVID-19. Some randomized clinical trials assessing the effects of different drugs have been published, and more are currently underway. There is an urgent need for a living, dynami
Parkinson's disease (PD) is a neurodegenerative disorder characterized by protein inclusions mostly composed of aggregated forms of α-synuclein (α-Syn) and by the progressive degeneration of midbrain dopaminergic neurons (mDANs), resulting in motor symptoms. While other brain regions also undergo pathologic changes in PD, the relevance of α-Syn aggregation for the preferential loss of mDANs in PD
A variety of pathogenic bacteria can infect humans, and rapid species identification is crucial for the correct treatment. However, the identification process can often be time-consuming and depend on the cultivation of the bacterial pathogen(s). Here, we present a stand-alone, enzyme-free, optical DNA mapping assay capable of species identification by matching the intensity profiles of large DNA
