Popular Abstract in Swedish Försök att föreställa dig något som är så litet att det inte går att se i ett mikroskop, något som är betydligt mindre än både DNA och protein. Det är sådana molekyler jag har jobbat med i mitt avhandlingsarbete. Dessa små molekyler kallas mikroRNA och finns i alla celler och har betydelse för hur en cell uppför sig. De kan till exempel styra bildandet av nya nervcellerOnly a few decades ago, it was generally believed that gene expression was controlled in a unidirectional way, i.e. DNA was transcribed into RNA, which simply acted as a messenger molecule used to produce the protein that executed cellular functions. It was not until the 1970-80’s that RNA interference was proclaimed as a gene regulatory process, and now it is increasingly evident that non-coding

A measurement of splitting scales, as defined by the kT clustering algorithm, is presented for final states containing a W boson produced in proton-proton collisions at a centre-of-mass energy of 7 TeV. The measurement is based on the full 2010 data sample corresponding to an integrated luminosity of 36 pb(-1) which was collected using the ATLAS detector at the CERN Large Hadron Collider. Cluster

To evaluate vibrotactile perception at different frequencies in fingers and in foot in healthy girls and boys.

The role of policy instruments to promote the development and diffusion of energy efficient technologies has been repeatedly accentuated in the context of climate change and sustainable development. To better understand the impact of policy instruments and to provide insights into technology change, assessments of various kinds are needed. This study analyzes the introduction and development of en

This paper presents measurements of the GeV-scale electron beam energy for the storage rings at the synchrotron light source facilities Australian Synchrotron (AS) and SPEAR3 at SLAC. Resonant spin depolarization was employed in the beam energy measurement, since it is presently the highest precision technique and an uncertainty of order 10(-6) was achieved at SPEAR3 and AS. Using the resonant dep

Grå och sydlig ladlav är två av landets akut hotade lavar, båda knutna till obehandlad ved. Detta är ett substrat som försvinner att mer i landet, inte minst i Skåne. I denna artikel redogör Ulf Arup för ytterligare fynd av arterna i Skåne och omständigheterna runt dessa.

Aims: In Sweden approximately 3% of annual births are conceived using assisted reproductive technologies ( ART). In light of increasing use of ART in Sweden we estimate the lifetime future tax revenues of a child conceived by in-vitro fertilization ( IVF) to establish whether public subsidy of IVF represents sound fiscal policy. Methods: A modified generational accounting model was developed to ca

This article discusses humour as feminist literary strategy in the production of the Swedish author Kerstin Thorvall.

During recent decades women have made considerable advances in education and the labor market, even in fast-track professions such as law, medicine, and academia. While women have entered high-status professions, the career paths of some jobs have changed little and are still inflexible, which implies that professional gains may be offset by familial losses. We investigate continued childbearing,

The Swedish National Register for Systemic Treatment of Psoriasis (PsoReg) was established in 2006. This article analyzes the implementation phase of biologics in the treatment of moderate to severe psoriasis in Sweden in the period 2006-2012. Clinical studies have shown efficacy of biologic agents in psoriasis, but their relative effectiveness in real-world clinical practice has rarely been studi

Human cystatin C (HCC) is a family 2 cystatin inhibitor of papain-like (C1) and legumain-related (C13) cysteine proteases. In pathophysiological processes, the nature of which is not understood, HCC is codeposited in the amyloid plaques of Alzheimer's disease or Down's syndrome. The amyloidogenic properties of HCC are greatly increased in a naturally occurring L68Q variant, resulting in fatal cere

Leukotriene A(4) hydrolase (LTA4H) is a key enzyme in the inflammatory process of mammals. It is an epoxide hydrolase and an aminopeptidase of the M1 family of the MA clan of Zn-metallopeptidases. We have solved the crystal structure of LTA4H in complex with N-[3(R)-[(hydroxyamino)carbonyl]-2-benzyl-1-oxopropyl]-L-alanine, a potent inhibitor of several Zn-metalloenzymes, both endopeptidases and am

Popular Abstract in Swedish Diabetes är en snabbt växande folksjukdom som redan har drabbat 200 miljoner världen runt. Det finns två typer av sjukdomen: typ I samt typ II diabetes. Den förstnämnda drabbar vanligtvis de unga och beror på en s.k. autoimmun reaktion där kroppens egna immunförsvar av okänd anledning plötsligt inte känner igen insulincellerna och börjar attackera dem. Typ II diabetes uDiabetes affects around 200 million people worldwide. Curing diabetes would require the prevention of autoimmune destruction of beta cells and restoration of the beta cell mass restored either through regeneration or transplantation of the insulin producing cells. Islet transplantation according to the Edmonton protocol have been the most promising therapeutic option for Diabetes type I patients,

Most distributed optimization methods used for distributed model predictive control (DMPC) are gradient based. Gradient based optimization algorithms are known to have iterations of low complexity. However, the number of iterations needed to achieve satisfactory accuracy might be significant. This is not a desirable characteristic for distributed optimization in distributed model predictive contro

Objective. Postoperative fatigue syndrome (POFS) is a general and main complication after surgery. However, there is no stable and standardized animal model for POFS. The aim of the present study was to establish a rodent model of POFS by small intestinal resection, with POFS evaluated by acknowledged physical and behavioral methods. Material and Methods. Forty-two Sprague-Dawley rats were randoml

Objective To assess the use of lipid-lowering therapy in patients with known coronary heart disease (CHD), cerebrovascular disease or diabetes in a community-based population in Sweden considering expert recommendations. Methods A random sample of individuals aged >= 40 years who were surveyed in 1993-1994 were revisited 10 years later during 2003-2004 (n=724). A clinical investigation focused on