The COVID-19 pandemic has presented many challenges that have spurred biotechnological research to address specific problems. Diagnostics is one area where biotechnology has been critical. Diagnostic tests play a vital role in managing a viral threat by facilitating the detection of infected and/or recovered individuals. From the perspective of what information is provided, these tests fall into t

The precisionFDA Truth Challenge V2 aimed to assess the state of the art of variant calling in challenging genomic regions. Starting with FASTQs, 20 challenge participants applied their variant-calling pipelines and submitted 64 variant call sets for one or more sequencing technologies (Illumina, PacBio HiFi, and Oxford Nanopore Technologies). Submissions were evaluated following best practices fo

The integrity of a cell’s proteome depends on correct folding of polypeptides by chaperonins. The chaperonin TCP-1 ring complex (TRiC) acts as obligate folder for >10% of cytosolic proteins, including he cytoskeletal proteins actin and tubulin. Although its architecture and how it recognizes folding substrates are emerging from structural studies, the subsequent fate of substrates inside the TRiC

There are many ways to acquire and process diffusion MRI (dMRI) data for group studies, but it is unknown which maximizes the sensitivity to white matter (WM) pathology. Inspired by this question, we analyzed data acquired for diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) at 3T (3T-DTI and 3T-DKI) and DTI at 7T in patients with systemic lupus erythematosus (SLE) and healthy c

Background: Tumor-related hyperintensities in high b-value diffusion-weighted imaging (DWI) are radiologically important in the workup of gliomas. However, the white matter may also appear as hyperintense, which may conflate interpretation.Purpose: To investigate whether DWI with spherical b-tensor encoding (STE) can be used to suppress white matter and enhance the conspicuity of glioma hyperinten

Presentation av enkät till alla kliniker som opererar pacemaker och utvärdering av effekten/kunskapen om HRG's riktlinjer för pacemaker- och ICD-kirurgi

Automotive brake rotors are commonly made from gray cast iron (GCI). During usage, brake rotors are gradually worn off and periodically replaced. Currently, replaced brake rotors are mostly remelted to produce brand-new cast iron products, resulting in a relatively high energy consumption and carbon footprint into the environment. In addition, automotive brakes emit airborne particles. Some of the

This research set out to identify pathways from vulnerability and stressors to depression in a global population of young athletes. Retrospective data were collected at age 18–19 years from Athletics athletes (n = 1322) originating from Africa, Asia, Europe, Oceania, and the Americas. We hypothesised that sports-related and non-sports-related stressors in interaction with structural vulnerability

Marina sediment kan stabiliseras med ultrahöghållfasta bindemedel: cement, Cement Kiln Dust (CKD) och slagg. Egenskaperna hos den stabiliserade jorden indikerar potential för återanvändning. Den här studien undersökte prestandan för den enaxiella tryckhållfastheten (UCS) i smarina sediment stabiliserade med bindemedel (cement, CKD, slagg), testade med ultraljuds P-vågor. Material omfattar 194 prov

Cement är ett viktigt byggmaterial inom anläggnings- och geoteknik. Men dess tillämpningar för stabilisering av marina sediment behöver ytterligare undersökas. Denna artikel undersöker effekterna av olika mängder portlandcement tillsatt till sedimentprover vid urlakning av tributyltenn (TBT) från det förorenade marina sedimenterar och utvärderar pH-nivån. Identifiera de bästa kombinationerna av Po

Att vara soldat är väldigt fysiskt krävande, det viktigt att upprätthålla en god fysisk kapacitetsnivå för att klara sin tjänst. Vid militära operationer arbetar soldater på lägre fysiska kravnivåer under lång tid för att ibland gå upp på intensiva kravnivåer. Framgång vid militära operationer är ofta beroende på soldaternas fysiska kapacitet, rörlighet och förmågan att bära sin utrustning. Det är

Resilience and gender have become new buzzwords for expressing renewal in peacebuilding. This article unpacks the gender-resilience nexus in theory and analyses global trends and variation in peacebuilding policy and practice. It advances an analytical framework based on three central pillars of peacebuilding: process, outcome, and expertise. A comprehensive analysis of 49 international peacebuild

In delay eye blink conditioning, the conditioned stimulus (CS) ends at the time of the unconditioned stimulus (US). If the CS duration is decreased, there will be a 'trace' period with no ongoing CS before the onset of the US. During this period some neural activity has to continue after the CS offset to: (i) permit association between the CS and the US; and (ii) elicit a conditioned response appe

1. Lesions of the cerebellar cortex can abolish classically conditioned eyeblink responses, but some recovery with retraining has been observed. It has been suggested that the recovered responses are generated by the intact contralateral cerebellar hemisphere. In order to investigate this suggestion, bilaterally acquired conditioned responses were studied after the unilateral blockade of cerebella

To fulfill the increasing demand for high-speed electronics used for computation or communication is one everlasting challenge for the semiconductor industry. Emerging fields such as quantum computation also has a need for circuits operating at cryogenic temperatures. The metal-oxide-semiconductor field-effect transistor (MOSFET) is the main component in modern electronics, traditionally fabricate