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PlyKp104, a Novel Phage Lysin for the Treatment of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Other Gram-Negative ESKAPE Pathogens
Klebsiella pneumoniae and Pseudomonas aeruginosa are two leading causes of burn and wound infections, pneumonia, urinary tract infections, and more severe invasive diseases, which are often multidrug resistant (MDR) or extensively drug resistant. Due to this, it is critical to discover alternative antimicrobials, such as bacteriophage lysins, against these pathogens. Unfortunately, most lysins tha
High-speed 3D imaging of liquid jets, surfaces and respiratory droplets
Sprays are commonly found in, among other, combustion, agriculture and food processing. For each of these applications, the understanding of spray liquid dynamics is crucial for optimization of efficiency, accuracy, and robustness of the spray-system in use. Sprays are also found as a collection of respiratory droplets ejected when people are speaking, yelling, coughing etc. that is one of the ma
Sequence enrichment profiles enable target-agnostic antibody generation for a broad range of antigens
Phenotypic drug discovery (PDD) enables the target-agnostic generation of therapeutic drugs with novel mechanisms of action. However, realizing its full potential for biologics discovery requires new technologies to produce antibodies to all, a priori unknown, disease-associated biomolecules. We present a methodology that helps achieve this by integrating computational modeling, differential antib
Trends in kidney transplantation rate across Europe : a study from the ERA Registry
Background. The aim of this study was to identify trends in total, deceased donor (DD) and living donor (LD) kidney transplantation (KT) rates in European countries. Methods. The European Renal Association (ERA) Registry and the Global Observatory on Donation and Transplantation (GODT) databases were used to obtain the number of KTs in individual European countries between 2010 and 2018. General p
Många källor till problem i systematiska översikter
A well-conducted systematic review requires a scrupulous assessment of the design of included studies. This may unveil major issues in how studies were planned, conducted and reported. This section presents a few examples. 1) A Cochrane review on pain and sedation management in the newborn identified a study described as a randomized trial, which later, following communication with authors and the
uORF4u : a tool for annotation of conserved upstream open reading frames
Summary: Upstream open reading frames (uORFs, often encoding so-called leader peptides) can regulate translation and transcription of downstream main ORFs (mORFs) in prokaryotes and eukaryotes. However, annotation of novel functional uORFs is challenging due to their short size of usually
Impact of string interactions on the space–time evolution of hadronic vertices
We investigate the space–time picture of string evolution and hadron production in a fully string-based model for high energy collisions involving heavy-ions. We find that although the density of strings is quite large at the time of hadronization in a central heavy-ion collision, the initial overlap between them right after the collisions is not necessarily large. We also find that when including
Understanding the evolution of immune genes in jawed vertebrates
Driven by co-evolution with pathogens, host immunity continuously adapts to optimize defence against pathogens within a given environment. Recent advances in genetics, genomics and transcriptomics have enabled a more detailed investigation into how immunogenetic variation shapes the diversity of immune responses seen across domestic and wild animal species. However, a deeper understanding of the d
Sparse spike trains and the limitation of rate codes underlying rapid behaviours
Animals live in dynamic worlds where they use sensorimotor circuits to rapidly process information and drive behaviours. For example, dragonflies are aerial predators that react to movements of prey within tens of milliseconds. These pursuits are likely controlled by identified neurons in the dragonfly, which have well-characterized physiological responses to moving targets. Predominantly, neural
Gothenburg Sustainable Development Search Strings 2019
This set of search strings was developed collaboratively by Gothenburg University Library and the Gothenburg Centre for Sustainable Development between 2017-2019.
Skin and wound delivery systems for antimicrobial peptides
Non-healing wounds cause hundreds of thousands of deaths every year, and result in large costs for society. A key reason for this is the prevalence of challenging bacterial infections, which may dramatically hinder wound healing. With resistance development among bacteria against antibiotics, this situation has deteriorated during the last couple of decades, pointing to an urgent need for new woun
Evolution of structure and shapes in Er 158 to ultrahigh spin
The level structure of Er158 has been studied using the Gammasphere spectrometer via the Cd114(Ca48,4n) reaction at 215 MeV with both thin (self-supporting) and thick (backed) targets. The level scheme has been considerably extended with more than 200 new transitions and six new rotational structures, including two strongly coupled high-K bands. Configuration assignments for the new structures are
Discussion of “Comparison of bias-corrected multisatellite precipitation products by deep learning framework”
VINTERGATAN-GM : The cosmological imprints of early mergers on Milky-Way-mass galaxies
We present a new suite of cosmological zoom-in hydrodynamical (≈ 20 pc spatial resolution) simulations of Milky-Way mass galaxies to study how a varying mass ratio for a Gaia-Sausage-Enceladus (GSE) progenitor impacts the z = 0 chemodynamics of halo stars. Using the genetic modification approach, we create five cosmological histories for a Milky-Way-mass dark matter halo (M200 ≈ 1012 M☉), incremen
Protect old-growth forests in Europe now
Decolonizing global health - what does it mean for us?
Temporal trends in cardiovascular risk factors, lifestyle and secondary preventive medication for patients with myocardial infarction attending cardiac rehabilitation in Sweden 2006-2019 : a registry-based cohort study
Objectives Registries have been highlighted as means to improve quality of care. Here, we describe temporal trends in risk factors, lifestyle and preventive medication for patients after myocardial infarction (MI) registered in the quality registry Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies (SWEDEHEART). D
Previous negative experiences of healthcare reported by Swedish pregnant women with fear of birth - A mixed method study
Background: Negative encounters in healthcare might affect women's health. During their reproductive life span, women are exposed to various health examinations, and have reported disrespectful care and obstetric violence. Such experiences might be a basis for fear of birth. Aim: to explore and describe the prevalence, associated factors and experiences of previous negative healthcare encounters i