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Background: The spread of tau pathology closely correlates with the disease course and cognitive decline in Alzheimer’s disease (AD). Tau-targeting immunotherapies are being developed to stop the spread of tau pathology and thus halt disease progression. In this post hoc analysis of the ADAMANT clinical trial, we examined the performance of AADvac1, an active immunotherapy targeting the microtubul

Lipid storage myopathies are considered inborn errors of metabolism affecting the fatty acid metabolism and leading to accumulation of lipid droplets in the cytoplasm of muscle fibers. Specific diagnosis is based on investigation of organic aids in urine, acylcarnitines in blood and genetic testing. An acquired lipid storage myopathy in patients treated with the antidepressant drug sertraline, a s

Body dysmorphic disorder (BDD) is a relatively common and highly impairing mental disorder that is strikingly underdiagnosed and undertreated in Child and Adolescent Mental Health Services (CAMHS). The only clinical guidelines for the management of BDD in youth were published nearly 20 years ago, when empirical knowledge was sparse. Fortunately, there has been a surge in research into BDD over the

The Covid-19 pandemic significantly influenced public discourse, particularly on the use of face masks, with social media serving as a platform for the public to express their opinions and share experiences. This study examines how the Swedish public supports their arguments when discussing their stance on face masks during the Covid-19 pandemic, split into three categories: (1) personal opinions,

The invasive golden apple snail Pomacea canaliculata is one of the devastating threats to aquatic ecosystems and wetland agriculture worldwide. Macrolides from microbes display various advantages over other compounds in controlling snails. However, emergence of antibiotic-resistant phenotypes against certain macrolides in the field appeals for exploring more effectively molluscicidal macrolides. H

A study of submicron-sized InGaN containing a single quantum well, intended for use as nano-light-emitting diodes in high-resolution display based on direct emission, is presented. Herein, the structures are grown by a bottom-up method from holes in a masked GaN/sapphire substrate and are intended for red emission. Many of the platelets show dark lines in cathodoluminescence images, previously ide

Welfare technology (WT), defined as digital technology enabling individuals to live securely, actively and independently at home, is often viewed as a solution to care resource shortages. This solution discourse has increasingly been problematised, and ethical issues specifically connected to WT have emerged, e.g., regarding quality of care. The existing array of WT is developed with limited user

School-based bullying is a widespread issue, but it occurs less often when bystanders defend the victims. This study examined whether type of bullying and students’ trust in their teacher’s ability to manage the class would be associated with reaction of the bystander (i.e. defending, passive, and pro-bullying). The participants were 202 ninth-grade students in Sweden, aged 15 years, who completed

Human–robot collaboration (HRC) in manufacturing environments requires that physical safety can be guaranteed. Control methods that implicitly regulate the interaction forces between a controlled robot and its environment, such as impedance control, are often used for safety in HRC. However, these methods could be complemented by restricting the robot operational space for additional safety guaran

Immunocompromised patients, especially those receiving B-cell depleting therapies, are at risk for developing atypical presentation with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, with the potential for diagnostic delay and adverse outcomes if such delay occurs. A 66-year-old female with history of granulomatosis with polyangiitis (GPA) with previous pulmonar

In this paper, an iterative learning strategy was developed to improve trajectory tracking for an impedance-controlled robot manipulator. In this learning strategy, an update law was proposed to modify the Cartesian reference of an impedance controller. Also, the conditions that ensure its convergence considering the dynamics of the robot were derived. Finally, an experimental evaluation was perfo

The concept of service user and other related concepts such as service user participation, service user influence and service user perspective have in recent decades gained increased importance in discussions about the development of social work practice, research and education. However, when these concepts are used, there is sometimes a lack of a well-thought-trough reflection on what is meant. W

The ability of people to act on their knowledge of their surrounding physical environments before, in response to, and after impactful climate-related hazards is shaped by broader environmental and socio-economic conditions. We present a multiple case study that illustrates how people from both non-Indigenous and Indigenous communities living in remote areas in the Nordic countries maintain and ad

An engineering model for estimating hot gas layer height is presented. The model is based on several sub-models, thus necessitating benchmarking against experimental data. Results from the model are compared to data from three different series of enclosure fire tests. The results indicate a strong correlation between the proposed model and the experimental observations, with an average error of leAn engineering model for estimating hot gas layer height is presented. The model is based on several sub-models, thus necessitating benchmarking against experimental data. Results from the model are compared to data from three different series of enclosure fire tests. The results indicate a strong correlation between the proposed model and the experimental observations, with an average error of le

Navigation performance in urban and large-scale built-up spaces (e.g. airports, train-stations, hospitals) depends on gradual environmental perception during locomotion, and spatial knowledge acquisition, update/integration at different times along a path. Rotational locomotion is regularly involved in everyday navigation; this, combined with the fact that people cannot perceive the whole of a lar

Key recommendationsPastureland restoration must be implemented to reduce dependency oncoping mechanisms such as emergency feeding, mechanized transport andintense workloads. These coping mechanisms are increasingly used to dealwith the cumulative effects of encroachments from competing land uses,predator pressure, and the impacts of climate change on snow conditions.Vigorous thinning of dense, man

BACKGROUND: Postural instability is considered a late complication of Parkinson’sdisease (PD). However, growing evidence shows that balance and gait problems mayoccur early in the disease.OBJECTIVE: To describe balance, gait, and falls/near falls in persons with newlydiagnosed, untreated PD (“de novo”), and to compare this with persons with mildmoderatePD (Later PD). In addition, we evaluated diffBackgroundPostural instability is considered a late complication of Parkinson’s disease (PD). However, growing evidence shows that balance and gait problems may occur early in the disease.ObjectiveTo describe balance, gait, and falls/near falls in persons with newly diagnosed, untreated PD (“de novo”), and to compare this with persons with mild-moderate PD (Later PD). In addition, we evaluated dif

This study investigates age-related biases in AI-generated art through a mixed method investigation of images of older and younger individuals. Employing 19 text prompts associated with social exclusion for older adults, we collected 465 images from an AI-art generator, MidJourney, and conducted quantitative and qualitative analyses to understand differences between age group depictions. We used A